Changes in Physiological and Pathological Behaviours Produced by Deep Microelectrode Implantation Surgery in Rats: A Temporal Analysis.

Abstract:

:Physiological behaviours such as the sleep-wake cycle and exploratory behaviours are important parameters in intact and sham-operated animals and are usually thought to be unaffected by experimental protocols in which neurosurgery is performed. However, there is insufficient evidence in the literature on the behavioural and cognitive effects observed after deep microelectrode implantation surgery in animal models of neurological diseases. Similarly, in studies that utilize animal models of neurological diseases, the impact of surgery on the pathological phenomena being studied is often minimized. Based on these considerations, we performed a temporal analysis of the effects of deep microelectrode implantation surgery in the hippocampus of rats on quiet wakefulness, sleep, and exploratory activity and the pathological behaviours such as convulsive seizures according to the Racine scale. Male Wistar rats (210-300 g) were used and grouped in sham and epileptic animals. Single doses of pilocarpine hydrochloride (2.4 mg/2 μl; i.c.v.) were administered to the animals to generate spontaneous and recurrent seizures. Deep microelectrode implantation surgeries in both groups and analysis of Fast ripples were performed. Physiological and pathological behaviours were recorded through direct video monitoring of animals (24/7). Our principal findings showed that in epileptic animals, one of the main behaviours affected by surgery is sleep; as a consequence of this behavioural change, a decrease in exploratory activity was also found as well as the mean time spent daily in seizures of scale 4 and the number of seizure events of scales 4 and 5 was increased after surgery. No significant correlations between the occurrence of FR and seizure events of scale 4 (rho 0.63, p value 0.25) or 5 (rho -0.7, p value 0.18) were observed. In conclusion, microelectrode implantation surgeries modified some physiological and pathological behaviours; therefore, it is important to consider this fact when it is working with animal models.

journal_name

Behav Neurol

journal_title

Behavioural neurology

authors

Chiprés-Tinajero GA,Núñez-Ochoa MA,Medina-Ceja L

doi

10.1155/2020/4385706

subject

Has Abstract

pub_date

2020-03-09 00:00:00

pages

4385706

eissn

0953-4180

issn

1875-8584

journal_volume

2020

pub_type

杂志文章
  • Syndrome-specific deficits of performance and effects of practice on arm movements with deafferentation due to posterior thalamic lesion.

    abstract::Aiming and tapping movements were analysed repeatedly over a three-week period in a patient who was hemideafferented due to an ischaemic posterior thalamic lesion. Contrasting behaviour observed in six healthy subjects, nine hemiparetic patients and one patient with hemianopic stroke, allowed the determination of beha...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1997-10103

    authors: Platz T,Mauritz KH

    更新日期:1997-01-01 00:00:00

  • A case of frontotemporal lobar degeneration with progressive dysarthria.

    abstract::We investigated the evolution of the neurological and neuropsychological characteristics in a right-handed woman who was 53-years-old at the onset and who showed personality changes and behavioral disorders accompanied by progressive dysarthria. She had hypernasality and a slow rate of speech with distorted consonants...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2006/320638

    authors: Ihori N,Araki S,Ishihara K,Kawamura M

    更新日期:2006-01-01 00:00:00

  • Therapy efficacy in chronic aphasia.

    abstract::There is good evidence that aphasia therapy is effective if sufficiently prolonged or intensive and that chronic aphasic individuals can also benefit from therapy, but data on chronic aphasia are scanty. The aim of this retrospective study was to investigate whether chronic aphasia benefits from a very intensive thera...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-2011-0342

    authors: Basso A,Macis M

    更新日期:2011-01-01 00:00:00

  • A Repeated Measures Pilot Comparison of Trajectories of Fluctuating Endogenous Hormones in Young Women with Traumatic Brain Injury, Healthy Controls.

    abstract:Objective:To compare baseline and 72-hour hormone levels in women with traumatic brain injury (TBI) and controls. Setting:Hospital emergency department. Participants:21 women ages 18-35 with TBI and 21 controls. Design:Repeated measures. Main Measures:Serum samples at baseline and 72 hours; immunoassays for estradi...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2019/7694503

    authors: Niemeier JP,Perrin PB,Hurst BS,Foureau DM,Huynh TT,Evans SL,Silverman JE,Elise McClannahan M,Brusch BD,Newman M,Mougeot JL,Wagner AK

    更新日期:2019-02-12 00:00:00

  • Neuropsychological and Emotional Functioning in Patients with Cushing's Syndrome.

    abstract::Patients with Cushing's syndrome (CS) frequently report impairments in cognitive and emotional functioning. Given neuroimaging research that implicates alterations in structure and function in the brain in this population, goals of this study were to investigate neuropsychological and emotional functioning, with parti...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2020/4064370

    authors: Na S,Fernandes MA,Ioachimescu AG,Penna S

    更新日期:2020-08-07 00:00:00

  • Prefrontal abilities.

    abstract::The neuroanatomical region that has most prominently altered with the advancing cognitive competency of the human is the prefrontal cortex, particularly the rostral extreme. While the prefrontal cortex does not appear to contain the neural networks that carry out cognitive activities, the management of these high leve...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1993-6202

    authors: Benson DF

    更新日期:1993-01-01 00:00:00

  • Effects of Different Types of Cognitive Training on Cognitive Function, Brain Structure, and Driving Safety in Senior Daily Drivers: A Pilot Study.

    abstract:BACKGROUND:Increasing proportion of the elderly in the driving population raises the importance of assuring their safety. We explored the effects of three different types of cognitive training on the cognitive function, brain structure, and driving safety of the elderly. METHODS:Thirty-seven healthy elderly daily driv...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2015/525901

    authors: Nozawa T,Taki Y,Kanno A,Akimoto Y,Ihara M,Yokoyama R,Kotozaki Y,Nouchi R,Sekiguchi A,Takeuchi H,Miyauchi CM,Ogawa T,Goto T,Sunda T,Shimizu T,Tozuka E,Hirose S,Nanbu T,Kawashima R

    更新日期:2015-01-01 00:00:00

  • The Effects of Gender Differences in Patients with Depression on Their Emotional Working Memory and Emotional Experience.

    abstract::A large amount of research has been conducted on the effects of sex hormones on gender differences in patients with depression, yet research on cognitive differences between male and female patients with depression is insufficient. This study uses emotion pictures to investigate the differences of the emotional workin...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2015/807343

    authors: Li M,Lu S,Wang G,Zhong N

    更新日期:2015-01-01 00:00:00

  • Association between Neuron-Specific Enolase Gene Polymorphism and Delayed Encephalopathy after Acute Carbon Monoxide Poisoning.

    abstract:Objective:The aim of this study is to explore the relationship between neuron-specific enolase (NSE) gene polymorphism and delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) and provide a theoretical basis for DEACMP pathogenesis, diagnosis, and prognosis. Methods:To investigate this relationship, w...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2020/8819210

    authors: Xu L,Liu X,Zhao J,Zeng J,Gu J,Zhang X,Zhang F,Han Y,Li W,Zhang P,Gu R

    更新日期:2020-10-14 00:00:00

  • Behavioural Changes in Mice after Getting Accustomed to the Mirror.

    abstract::Patients with brain function disorders due to stroke or dementia may show inability to recognize themselves in the mirror. Although the cognitive ability to recognize mirror images has been investigated in many animal species, the animal species that can be used for experimentation and the mechanisms involved in recog...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2020/4071315

    authors: Ueno H,Suemitsu S,Murakami S,Kitamura N,Wani K,Takahashi Y,Matsumoto Y,Okamoto M,Ishihara T

    更新日期:2020-02-03 00:00:00

  • Can tactile neglect occur at an intra-limb level? Vibrotactile reaction times in patients with right hemisphere damage.

    abstract::Visual reaction time (RT) studies on patients with right hemisphere (RH) damage have demonstrated that the attentional imbalance to stimuli occupying left and right positions exists even within the "intact" ipsilesional hemifield. The purpose of the present study was to test whether such patients might also exhibit re...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1994-7204

    authors: Mattingley JB,Bradshaw JL

    更新日期:1994-01-01 00:00:00

  • Voice recognition impairment in a blind Capgras patient.

    abstract::We report a case of a blind woman, M.N., who experienced the Capgras delusion. She thought that her pet cat had been replaced by a replica which was "ill-intentioned" towards her. M.N.'s case shows that the basis of the Capgras delusion cannot lie exclusively in damage to the visual system. However, testing of M.N.'s ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1993-6409

    authors: Reid I,Young AW,Hellawell DJ

    更新日期:1993-01-01 00:00:00

  • Is there a place for ipsilesional eye patching in neglect rehabilitation?

    abstract::Neglect behavior of experimental animals with unilateral posterior cortical lesions improves with the placement of a second lesion in the contralesional superior colliculus or in the intercollicular commissure. Given that the retinotectal fibers are mainly crossed, it has been speculated that ipsilesional eye patching...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1994-73-408

    authors: Soroker N,Cohen T,Baratz C,Glicksohn J,Myslobodsky MS

    更新日期:1994-01-01 00:00:00

  • Neuropsychological rehabilitation in mild and moderate Alzheimer's disease patients.

    abstract:OBJECTIVE:The purpose of this study was to analyze the effect of a neuropsychological rehabilitation (NR) program on patients with Alzheimer's disease (AD). METHODS:The sample was composed of 16 elderly outpatients who participated in an open trial with rivastigmine (6 to 12 mg/day) for 4 months and were randomized to...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2007/915816

    authors: Avila R,Carvalho IA,Bottino CM,Miotto EC

    更新日期:2007-01-01 00:00:00

  • Aggressive behaviour in Huntington's disease: a cross-sectional study in a nursing home population.

    abstract::We describe a cross-sectional study of aggressive behaviour in a sample of patients suffering from Huntington's disease in a residential nursing home. Data were obtained using the RAGE, a behaviourally oriented rating scale for measuring aggressive behaviour in cognitively impaired patients. Nursing staff rated 27 pat...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1993-6107

    authors: Shiwach RS,Patel V

    更新日期:1993-01-01 00:00:00

  • Late-onset startle syndrome and obsessive compulsive disorder.

    abstract::A case of late onset sporadic startle syndrome in a patient with a right posterior fossa brain tumour is reported. The exaggerated startle response did not respond to treatment with clonazepam. In addition to anxiety and depression, the patient developed obsessive- compulsive symptoms which responded to behavioural th...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/1998/617160

    authors: Gonzalez A,Philpot MP

    更新日期:1998-01-01 00:00:00

  • Tardive dystonia: clinical spectrum and novel manifestations.

    abstract::Tardive dystonia was identified in 25 patients: involvement of the face and neck was most common; truncal and limb dystonia were also observed. There were 3 cases of laryngospasm and 2 of spasmodic dysphonia. The latter has not been previously reported as a manifestation of tardive dystonia. In all cases, movements ty...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1988-1106

    authors: Davis RJ,Cummings JL,Hierholzer RW

    更新日期:1988-01-01 00:00:00

  • Neurological soft signs in obsessive compulsive disorder: standardised assessment and comparison with schizophrenia.

    abstract::While several studies have detected raised levels of neurological soft signs in patients with obsessive compulsive disorder (OCD), the specificity of these abnormalities remains uncertain. This study used a new standardised measure, the Cambridge Neurological Inventory (CNI), to assess soft signs in 51 subjects with O...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/1999/639045

    authors: Bolton D,Gibb W,Lees A,Raven P,Gray JA,Chen E,Shafran R

    更新日期:1998-01-01 00:00:00

  • Computed tomographic density changes in schizophrenic and manic Nigerian subjects.

    abstract::There is paucity of computed tomography (CT) studies from developing countries, where schizophrenia is said to have more favourable outcome and present predominantly with positive symptoms. We highlight the densitometric analysis of frontal and parietal areas, assessed by tracing of regions of interest on the slice th...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1995-8104

    authors: Ohaeri JU,Adeyinka AO,Osuntokun BO

    更新日期:1995-01-01 00:00:00

  • A crossed Kana agraphia.

    abstract::We report a right-handed man who developed selective Kana (phonogram) agraphia following an infarct in the non-dominant right cerebral hemisphere. His ability for comprehension, reading and writing of Kanji (ideogram) was unaffected. Kana errors consisted of substitution with another letter and the number of target wo...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1995-8208

    authors: Abe K,Yokoyama R,Yanagihara T

    更新日期:1995-01-01 00:00:00

  • Sevoflurane Impairs Short-Term Memory by Affecting PSD-95 and AMPA Receptor in the Hippocampus of a Mouse Model.

    abstract:Objective:To explore the effects of sevoflurane on the latency and error times of the passive avoidance and levels of PSD-95 and AMPA receptors in the hippocampus. We evaluated the effects of sevoflurane on short-term memory in adult mice and explored the possible mechanism. Methods:144 Kunming mice (2-3 months, 30-35...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2019/1068260

    authors: Jiao Y,Fan H,Wang K,Lu S

    更新日期:2019-10-21 00:00:00

  • Alois Alzheimer and Gaetano Perusini: should man divide what fate united?

    abstract::Three points of interest lie in considering how Alzheimer, and more significantly Perusini, struggled to throw light on the cause of this devastating disease. There is a stimulating possibility that Perusini believed presenile forms of Alzheimer's disease described the same disease as senile forms. If so this would an...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1997-10401

    authors: Macchi G,Brahe C,Pomponi M

    更新日期:1997-01-01 00:00:00

  • Bi-hemispheric engagement in the retrieval of autobiographical episodes.

    abstract::Functional magnetic resonance imaging (fMRI) was used to study the neural correlates of neutral, stressful, negative and positive autobiographical memories. The brain activity produced by these different kinds of episodic memory did not differ significantly, but a common pattern of activation for different kinds of au...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2005/460745

    authors: Vandekerckhove MM,Markowitsch HJ,Mertens M,Woermann FG

    更新日期:2005-01-01 00:00:00

  • Treatment of Tourette syndrome with cannabinoids.

    abstract::Cannabinoids have been used for hundred of years for medical purposes. To day, the cannabinoid delta-9-tetrahydrocannabinol (THC) and the cannabis extract nabiximols are approved for the treatment of nausea, anorexia and spasticity, respectively. In Tourette syndrome (TS) several anecdotal reports provided evidence th...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.3233/BEN-120276

    authors: Müller-Vahl KR

    更新日期:2013-01-01 00:00:00

  • From Broca and Wernicke to the Neuromodulation Era: Insights of Brain Language Networks for Neurorehabilitation.

    abstract::Communication in humans activates almost every part of the brain. Of course, the use of language predominates, but other cognitive functions such as attention, memory, emotion, and executive processes are also involved. However, in order to explain how our brain "understands," "speaks," and "writes," and in order to r...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.1155/2019/9894571

    authors: Nasios G,Dardiotis E,Messinis L

    更新日期:2019-07-22 00:00:00

  • Objectively Measured Physical Activity Is Associated with Brain Volumetric Measurements in Multiple Sclerosis.

    abstract:BACKGROUND:Little is known about physical activity and its association with volumes of whole brain gray matter and white matter and deep gray matter structures in persons with multiple sclerosis (MS). PURPOSE:This study examined the association between levels of physical activity and brain volumetric measures from mag...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2015/482536

    authors: Klaren RE,Hubbard EA,Motl RW,Pilutti LA,Wetter NC,Sutton BP

    更新日期:2015-01-01 00:00:00

  • Psychogenic and organic amnesia: a multidimensional assessment of clinical, neuroradiological, neuropsychological and psychopathological features.

    abstract::Psychogenic amnesia is a complex disorder characterised by a wide variety of symptoms. Consequently, in a number of cases it is difficult distinguish it from organic memory impairment. The present study reports a new case of global psychogenic amnesia compared with two patients with amnesia underlain by organic brain ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2007/193140

    authors: Serra L,Fadda L,Buccione I,Caltagirone C,Carlesimo GA

    更新日期:2007-01-01 00:00:00

  • Mapping remote subcortical ramifications of injury after ischemic strokes.

    abstract:BACKGROUND:The extent of brain damage in chronic stroke patients is traditionally defined as the necrotic tissue observed on magnetic resonance image (MRI). However, patients often exhibit symptoms suggesting that functional impairment may affect areas beyond the cortical necrotic lesion, for example, when cortical sym...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2014/215380

    authors: Bonilha L,Nesland T,Rorden C,Fillmore P,Ratnayake RP,Fridriksson J

    更新日期:2014-01-01 00:00:00

  • Analysis of HMPAO SPECT scans in head injury using Statistical Parametric Mapping.

    abstract::The paper examines the ability of Statistical Parametric Mapping (SPM) to contribute towards the quantitative analysis of HMPAO SPECT images containing lesions. A validation study is described in which SPECT images were created that contained synthetic lesions and were analysed with SPM. The study established a set of...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2000/681916

    authors: Stamatakis EA,Wilson JT,Wyper DJ

    更新日期:2000-01-01 00:00:00

  • Lack of noradrenergic modulation of indirect semantic priming.

    abstract::Norepinephrine and dopamine are both believed to affect signal-to-noise in the cerebral cortex. Dopaminergic agents appear to modulate semantic networks during indirect semantic priming, but do not appear to affect problem solving dependent on access to semantic networks. Noradrenergic agents, though, do affect semant...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-2009-0236

    authors: Cios JS,Miller RF,Hillier A,Tivarus ME,Beversdorf DQ

    更新日期:2009-01-01 00:00:00