Fenamates Inhibit Human Sodium Channel Nav1.2 and Protect Glutamate-Induced Injury in SH-SY5Y Cells.

abstract：:Normokalemic periodic paralysis (normoPP) is a type of skeletal muscle function disorder which is characterized by paralysis attack with concomitant normal serum potassium level. We previously reported that R675Q mutation of human skeletal muscle voltage-gated sodium channel α subunit (SCN4A) may be the novel mutation...

journal_title：Cellular and molecular neurobiology

authors： Wu L,Zhang B,Kang Y,Wu W

更新日期：2014-07-01 00:00:00

abstract：:Elevated iron levels in the substantia nigra (SN) participate in neuronal death in Parkinson's disease (PD), while the mechanisms underlying the increased iron are still unknown. Ceruloplasmin (CP), a ferroxidase, converts highly toxic ferrous iron to its non-toxic ferric form, which cooperated with ferroportin1 (FP1)...

journal_title：Cellular and molecular neurobiology

authors： Wang J,Bi M,Xie J

更新日期：2015-07-01 00:00:00

abstract：:Hypoxia in neonates can lead to biochemical and molecular alterations mediated through changes in neurotransmitters resulting in permanent damage to brain. In this study, we evaluated the changes in the receptor status of GABA(A) in the cerebral cortex and brainstem of hypoxic neonatal rats and hypoxic rats supplement...

journal_title：Cellular and molecular neurobiology

authors： Anju TR,Peeyush Kumar T,Paulose CS

更新日期：2010-05-01 00:00:00

abstract：:Microelectrophoretic application of sex hormones onto pineal cells in guinea pigs has shown different responses in pregnant females as compared to males. In pregnant females estrone caused excitation in 74% of the cells tested, while progesterone and testosterone, prolactin, and HCG were inhibitory in a majority of th...

journal_title：Cellular and molecular neurobiology

authors： Semm P,Demaine C,Vollrath L

更新日期：1981-09-01 00:00:00

abstract：:1. We have used horseradish peroxidase-conjugated protein A- and 125I-protein A to develop immunohistochemical and radioimmunohistochemical methods for the localization of antigens in brain and other tissues of the rat. 2. We visualized methionine-enkephalin fibers in the rat brain by incubating tissue sections with a...

journal_title：Cellular and molecular neurobiology

authors： Correa FM,Guilhaume SS,Saavedra JM

更新日期：1988-03-01 00:00:00

abstract：:Glycoproteins of the extracellular matrix (ECM) regulate proliferation, migration, and differentiation in numerous cell lineages. ECM functions are initiated by small peptide sequences embedded in large constituents that are recognized by specific cellular receptors. In this study, we have investigated the biological ...

journal_title：Cellular and molecular neurobiology

authors： Brösicke N,Sallouh M,Prior LM,Job A,Weberskirch R,Faissner A

更新日期：2015-07-01 00:00:00

abstract：:1. Melanin-concentrating hormone (MCH)-containing neurons within the lateral hypothalamus affect a broad spectrum of physiological and behavioral processes. The aim of this study was to examine a differentiation of rat MCH neurons dependent on their functionally related projections to the intermediolateral column (IML...

journal_title：Cellular and molecular neurobiology

authors： Harthoorn LF

更新日期：2007-02-01 00:00:00

abstract：:Depression is a major psychiatric disorder affecting nearly 21% of the world population and imposes a substantial health burden on society. Although significant progress has been made in depression research, the common molecular mechanism of antidepressants is still far from clearly understood. The neuroprotective eff...

journal_title：Cellular and molecular neurobiology

authors： Zheng M,Liu C,Pan F,Shi D,Ma F,Zhang Y,Zhang Y

更新日期：2011-04-01 00:00:00

abstract：:1. Innervation of the mammalian pineal gland is mainly sympathetic. Pineal synthesis of melatonin and its levels in the circulation are thought to be under strict adrenergic control of serotonin N-acetyltransferase (NAT). In addition, several putative pineal neurotransmitters modulate melatonin synthesis and secretion...

journal_title：Cellular and molecular neurobiology

authors： Laitinen JT,Laitinen KS,Kokkola T

更新日期：1995-04-01 00:00:00

abstract：:The mechanisms of impairment in long-term potentiation after status epilepticus (SE) remain unclear. We investigated the properties of LTP induced by theta-burst stimulation in hippocampal slices of rats 3 h and 1, 3, and 7 days after SE. Seizures were induced in 3-week old rats by a single injection of pentylenetetra...

journal_title：Cellular and molecular neurobiology

authors： Postnikova TY,Trofimova AM,Ergina JL,Zubareva OE,Kalemenev SV,Zaitsev AV

更新日期：2019-03-01 00:00:00

abstract：:Diabetes damages the central nervous system, inducing cognitive dysfunction and structural changes, known as diabetic encephalopathy (DE). Some research suggests that the pathogenesis of DE may involve an inflammatory imbalance in the nervous system, along with β-amyloid deposition, similar to Alzheimer's disease. Les...

journal_title：Cellular and molecular neurobiology

authors： Miao Y,He T,Zhu Y,Li W,Wang B,Zhong Y

更新日期：2015-11-01 00:00:00

abstract：:MicroRNAs are small non-coding RNAs which mediate post-transcriptional gene regulation. Recently, microRNAs have also been found to be localized to the extracellular space, often encapsulated in secreted extracellular vesicles (EVs). This tandem of EVs and tissue-specific expressed/secreted microRNAs that can be taken...

journal_title：Cellular and molecular neurobiology

authors： Bronisz A,Godlewski J,Chiocca EA

更新日期：2016-04-01 00:00:00

abstract：:We have used the nervous system of the medicinal leech as a preparation to study the molecular basis of neural repair. The leech central nervous system, unlike mammalian CNS, can regenerate to restore function, and contains identified nerve cells of known function and connectivity. We have constructed subtractive cDNA...

journal_title：Cellular and molecular neurobiology

authors： Wang WZ,Emes RD,Christoffers K,Verrall J,Blackshaw SE

更新日期：2005-03-01 00:00:00

abstract：:Calmodulin is known to transduce Ca(2+) signals by interacting with specific target proteins. In order to determine the role of calmodulin in regulating neuronal survival and death, we examined, whether calmodulin inhibitors induce caspase-dependent apoptotic cell death, and whether glycogen synthase kinase-3 is invol...

journal_title：Cellular and molecular neurobiology

authors： Takadera T,Ohyashiki T

更新日期：2007-09-01 00:00:00

abstract：:1. Data obtained studying permeability characteristics of single Deiters' membranes in a microchamber system show that intracellular GABA can activate chloride in-->out passage with a GABAA pharmacology. 2. The overall data suggest the presence of a chloride extrusion pump in these neurons based on intracellular GABA ...

journal_title：Cellular and molecular neurobiology

authors： Rapallino MV,Cupello A,Hydén H

更新日期：1999-12-01 00:00:00

abstract：:Cell cultures are characterized by their simplicity, controllability, and ability to provide detailed basic information on how a particular cell population responds to specific stimuli or insult. These characteristics led to their extensive application in the study of molecular interactions and represent a valuable to...

journal_title：Cellular and molecular neurobiology

authors： Roque C,Baltazar G

更新日期：2017-11-01 00:00:00

abstract：:Rosmarinic acid (RA) is a natural polyphenolic compound with a well-documented neuroprotective effect mainly associated with its anti-inflammatory and antioxidant activities. Recently, our research group developed and optimized chitosan-coated RA nanoemulsions (RA CNE) intended to be used for nasal delivery as a new p...

journal_title：Cellular and molecular neurobiology

authors： Fachel FNS,Dal Prá M,Azambuja JH,Endres M,Bassani VL,Koester LS,Henriques AT,Barschak AG,Teixeira HF,Braganhol E

更新日期：2020-01-01 00:00:00

abstract：:The NMDA receptor is the most widely studied ionotropic glutamate receptor, and it is central to many physiological and pathophysiological processes in the central nervous system. GluN2A is one of the two main types of GluN2 NMDA receptor subunits in the forebrain. The proper activity of GluN2A is important to brain f...

journal_title：Cellular and molecular neurobiology

authors： Sun Y,Zhan L,Cheng X,Zhang L,Hu J,Gao Z

更新日期：2017-04-01 00:00:00

abstract：:1. The possibility that a long-lasting neuronal activation regulates the expression of muscarinic cholinergic receptors was studied with three cultured neuronal cell lines. 2. Continuous depolarization of a subclone of the neuroblastoma-glioma NG108-15 hybrid cells with potassium chloride increased by 45-75% the numbe...

journal_title：Cellular and molecular neurobiology

authors： Simantov R,Levy R

更新日期：1989-03-01 00:00:00

abstract：:The anorexigenic molecule nesfatin-1 has recently been taken as a potential mood regulator, but the potential mechanisms remain unknown. Results of our previous study have demonstrated that nesfatin-1 could induce anxiety- and depression-like behaviors in rats, accompanied by the hyperactivity of the hypothalamic-pitu...

journal_title：Cellular and molecular neurobiology

authors： Chen Z,Xu YY,Ge JF,Chen FH

更新日期：2018-04-01 00:00:00

abstract：:We have investigated the action of the recombinant neurotoxins, named Hk7a and Hk2a, whose amino acid sequences differ only in two positions, isolated from the sea anemone Anthopleura sp., on neuronal sodium currents using the whole-cell voltage-clamp techniques. The rat cerebral cortical neurons in primary culture we...

journal_title：Cellular and molecular neurobiology

authors： Xiang H,Tao W,Wang L,Wang F,Xu A

更新日期：2008-12-01 00:00:00

abstract：:The prelimbic cortex (PL) is an important structure in the neural pathway integrating stress responses. Brain angiotensin is involved in cardiovascular control and modulation of stress responses. Blockade of angiotensin receptors has been reported to reduce stress responses. Acute restraint stress (ARS) is a stress mo...

journal_title：Cellular and molecular neurobiology

authors： Brasil TFS,Fassini A,Corrêa FM

更新日期：2018-01-01 00:00:00

abstract：:The irrefutable change in the expression of brain-enriched microRNAs (miRNAs) following ischemic stroke has promoted the development of radical miRNA-based therapeutics encompassing neuroprotection and neuronal restoration. Our previous report on the systems-level prediction of miR-9 in post-stroke-induced neurogenesi...

journal_title：Cellular and molecular neurobiology

authors： Nampoothiri SS,Rajanikant GK

更新日期：2019-03-01 00:00:00

abstract：:Naked2 (NKD2), one member of Naked family, has been shown to negatively regulate Wnt/β-catenin signaling pathway. It has been recognized that NKD2 plays a vital role in cell homeostasis and prevention of tumorigenesis. However, NKD2 expression and its functional role in the brain in neuroinflammatory processes remain ...

journal_title：Cellular and molecular neurobiology

authors： Cui Z,Zhou L,Song Y,Liu C,Zhu G,Wu X,Yan Y,Xia X,Duan C,Zhou Y,Huang Y,Zhang D

更新日期：2016-01-01 00:00:00

abstract：:Adeno-associated virus (AAV) has distinct advantages over other viral vectors in delivering genes of interest to the brain. AAV mainly transfects neurons, produces no toxicity or inflammatory responses, and yields long-term transgene expression. In this study, we first tested the hypothesis that AAV serotype 2 (AAV2) ...

journal_title：Cellular and molecular neurobiology

authors： Lin LH,Dragon DN,Jin J,Talman WT

更新日期：2011-08-01 00:00:00

abstract：:To clarify the role of angiotensin II (Ang II) in the regulation of sensory signaling, we studied the effect of subpressor dose (150 ng/kg/min) of Ang II on pain-related behavior in relation with neuronal injury and activation of satellite glial cells (SGCs) in the dorsal root ganglia (DRGs) after chronic constriction...

journal_title：Cellular and molecular neurobiology

authors： Pavel J,Oroszova Z,Hricova L,Lukacova N

更新日期：2013-07-01 00:00:00

abstract：:Membrane responses to cyclic adenosine monophosphate (cAMP) injections have been studied by means of voltage clamp, Ca-indicator dye, and ion substitution techniques in identified neurons from the abdominal ganglion of Limax maximus. The ventral abdominal giant cell (AGC) displayed a response consisting of a decrease ...

journal_title：Cellular and molecular neurobiology

authors： Hockberger P,Connor JA

更新日期：1984-12-01 00:00:00

abstract：:1. Effects of pentosan polysulfate (PPS) and the structurally related sulfated polyanions dextran sulfate, fucoidan, and heparin on the scavenger receptor-mediated and fluidphase endocytosis in GP8 immortalized rat brain endothelial cells were investigated. 2. Using 1,1'-dioctadecyl-3,3,3,3'-tetramethylindocarboxyamin...

journal_title：Cellular and molecular neurobiology

authors： Deli MA,Abrahám CS,Takahata H,Katamine S,Niwa M

更新日期：2000-12-01 00:00:00

abstract：:1. An identified dopaminergic interneuron (RPeD1) of the snail Lymnaea stagnalis, makes specific synaptic connections with a number of target (VI and VJ) but not non-target (VF and RPB) neurons in vivo. When cultured in vitro with both target and non-target cells, RPeD1 re-establishes synapses with target cells only. ...

journal_title：Cellular and molecular neurobiology

authors： Spencer GE,Lukowiak K,Syed NI

更新日期：1996-10-01 00:00:00

abstract：:In the present study, we investigated neuronal death/damage in the gerbil hippocampal CA1 region (CA1) and compared changes in some trophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), in the CA1 between the...

journal_title：Cellular and molecular neurobiology

authors： Yan BC,Park JH,Kim SK,Choi JH,Lee CH,Yoo KY,Kwon YG,Kim YM,Kim JD,Won MH

更新日期：2012-11-01 00:00:00