Discovery and Development of Gaseous Nitric Oxide Under Increased Atmospheric Pressure as an Antimicrobial: In Vitro and In Vivo Testing of Nitric Oxide Against Multidrug-Resistant Organisms.

Abstract:

:Gaseous nitric oxide under increased atmospheric pressure (gNOp) has shown ability to kill multidrug-resistant bacteria in an in vitro model and in a live mammalian (porcine) model. Factors impacting the kill rate of the multidrug-resistant bacteria include atmospheric pressures, concentration of gaseous NO, flow rate, and duration of application. Using successful in vitro parameters, gNOp showed multilog reduction of bacteria in a live mammalian (porcine) model. The in vitro testing system, using the EpiDerm-FT skin model (stem cell grown skin), was used to develop an infected wound model for Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, and methicillin-resistant S aureus.

journal_name

Clin Podiatr Med Surg

authors

Jensen J,Packert D,Miller C,Packert G,Hanft J,Jensen S

doi

10.1016/j.cpm.2019.11.001

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

231-246

issue

2

eissn

0891-8422

issn

1558-2302

pii

S0891-8422(19)30095-3

journal_volume

37

pub_type

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