[Concentration of cefotaxime in the exudate from ischemic ulcer after systemic and regional administration].

Abstract:

:We evaluated the concentration of cefotaxime in the exudate from ischemic leg ulcers in 9 subjects with severe obstructive arterial disease. The administration of the drug was either systemic (1 g in 250 ml of saline given in 30 min) or regional at a vein of the foot while a tourniquet was applied at the level of the thigh during 30 min. Hygroscopic discs were used to collect samples of ulcer exudate at hourly intervals for 4 hr. Cefotaxime concentration was determined by HPL chromatography. A significantly greater concentration of antibiotic was obtained with regional as compared to systemic administration (46 +/- 16 vs 25 +/- 14, p less than 0.01) and a greater percentage of patients attained MIC 90. A stable concentration of the drug was observed during the 4 hr period indicating a decreased rate of elimination of the antibiotic from the ulcer tissue. Thus, regional administration of antibiotics affords greater concentration than systemic administration, for treatment of ischemic leg ulcers.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Acevedo A,Schoop W

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

291-5

issue

3

eissn

0034-9887

issn

0717-6163

journal_volume

118

pub_type

杂志文章
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    authors: Gatica MA,Morales H,Harz C,Espinoza A

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    authors: Arcos E,Uarac M,Molina I,Repossi A,Ulloa M

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  • [Masters of Chilean Internal Medicine].

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  • [Aseptic meningitis following spinal anesthesia. Report of a case].

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    authors: Bugedo G,Valenzuela J,Muñoz H

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  • [Bovine serum albumin (BSA) antibodies in children with recently diagnosed type 1 diabetes with breast feeding and milk exposition].

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    authors: Blanco R,Jara L,Villaseca C,Palomino H,Carreño H

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    authors: Kunstmann S,Corbalán R,Olea E,Orellana P,Marchant E,Puschel K,Galleguillos CG

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  • [Learning strategies of autonomous medical students].

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  • [Hearing loss as a risk factor for dementia].

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  • [The hepatitis viruses: from A to TT].

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  • [Perceived work characteristics and coping strategies that predict distress among workers at primary health care centers].

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