Abstract：
PURPOSE:To determine the feasibility of using epileptiform events detected by continuous electrocorticographic monitoring via a brain-responsive neurostimulation system to supplement patient-maintained seizure diaries. METHODS:Data were retrospectively analyzed from a randomized controlled trial of brain-responsive neurostimulation (RNS® System) for adjunctive treatment of medically intractable focal onset seizures in 191 subjects. The long-term (≥3 months) correspondence between daily counts of diary-reported seizures and device-recorded "long epileptiform events" (LEs), a proxy for electrographic seizures (ESs), was assessed using cross-correlation and logistic generalized estimating equation models. RESULTS:Diary-reported seizures and LEs significantly co-varied across days in 124 patients whose detection settings were held constant, with a significantly higher correlation in 54 patients (44 %) whose LEs were usually ESs (high concordance patients). There were more days in which LEs were detected than days in which patients reported a seizure (positive predictive value (PPV): 34 %). On days when there were no LEs, there were typically no diary-reported seizures (negative predictive value (NPV): 90 %). In patients with a high concordance between LEs and ESs, the PPV and NPV were both slightly higher, 43 % (35-52 %) and 93 % (95 % CI: 86-97 %) respectively. CONCLUSION:Although LEs can substantially outnumber diary reported seizures, the high across-day correlation and strong NPV between LEs and diary seizures suggests that LEs recorded by the RNS® System could potentially supplement seizure diaries by providing an objective biomarker for relative seizure burden.
journal_name
Epilepsy Resjournal_title
Epilepsy researchauthors
Quigg M,Skarpaas TL,Spencer DC,Fountain NB,Jarosiewicz B,Morrell MJdoi
10.1016/j.eplepsyres.2020.106302subject
Has Abstractpub_date
2020-03-01 00:00:00pages
106302eissn
0920-1211issn
1872-6844pii
S0920-1211(19)30552-2journal_volume
161pub_type
杂志文章abstract：:Lithium is still the mainstay in the treatment of affective disorders as a mood stabilizer. Lithium also shows some anticonvulsant properties. While the underlying mechanisms of action of lithium are not yet exactly understood, we used a model of clonic seizure induced by pentylenetetrazole (PTZ) in male NMRI mice to ...
journal_title：Epilepsy research
pub_type： 杂志文章
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更新日期：2015-07-01 00:00:00
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pub_type： 杂志文章
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journal_title：Epilepsy research
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journal_title：Epilepsy research
pub_type： 杂志文章,评审
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journal_title：Epilepsy research
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pub_type： 杂志文章
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journal_title：Epilepsy research
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journal_title：Epilepsy research
pub_type： 杂志文章,meta分析,评审
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journal_title：Epilepsy research
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journal_title：Epilepsy research
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doi：10.1016/j.eplepsyres.2008.04.005
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Epilepsy research
pub_type： 杂志文章
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doi：10.1016/j.eplepsyres.2010.04.002
更新日期：2010-06-01 00:00:00
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journal_title：Epilepsy research
pub_type： 杂志文章
doi：10.1016/j.eplepsyres.2008.06.006
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journal_title：Epilepsy research
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1987-07-01 00:00:00
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pub_type： 杂志文章
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journal_title：Epilepsy research
pub_type： 杂志文章
doi：10.1016/s0920-1211(98)00121-1
更新日期：1999-05-01 00:00:00
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journal_title：Epilepsy research
pub_type： 杂志文章
doi：10.1016/0920-1211(90)90018-q
更新日期：1990-12-01 00:00:00
