A liquid-liquid LC/MS/MS assay for the determination of artemether and DHA in malaria patient samples.

Abstract:

:A solvent extraction method was developed and validated for the determination of the antimalarial drug, artemether and its active metabolite dihydroartemisinin (DHA) in malaria patient plasma samples. An AB Sciex 4000 triple quadrupole mass spectrometer in the multiple reaction monitoring (MRM) mode was used for detection in the positive ionisation mode. Liquid-liquid extraction was followed by PFP liquid chromatography and tandem mass spectrometry. Stable isotope labelled artemether and DHA was used as internal standards. The calibration range was between 2.00 and 500 ng/ml for both artemether and DHA during the original validation and the upper limit was lowered to 200 ng/ml during a re-instatement validation, prior to sample analysis. The assay was used to measure artemether and DHA in human plasma samples, which were generated from a safety and efficacy clinical trial in Mbarara, Uganda; as well as for a pharmacokinetic interaction study between the antimalarial combination artemether/lumefantrine and combination antiretroviral therapy including nevirapine in HIV-infected adults.

journal_name

J Pharm Biomed Anal

authors

Wiesner L,Govender K,Meredith SA,Norman J,Smith PJ

doi

10.1016/j.jpba.2011.01.036

subject

Has Abstract

pub_date

2011-05-15 00:00:00

pages

373-8

issue

2

eissn

0731-7085

issn

1873-264X

pii

S0731-7085(11)00061-6

journal_volume

55

pub_type

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