Abstract:
BACKGROUND:Lymphocyte-to-monocyte ratio (LMR) is involved in all stages of coronary atherosclerosis and related to coronary artery disease (CAD). However, the correlation between LMR and the coronary plaque burden of CAD is not clearly elucidated. Therefore, this study aimed to investigate their correlation in patients with CAD. METHODS:A total of 1953 consecutive eligible inpatients with suspected CAD were retrospectively included in this study. They were assigned into CAD (n = 564) and non-CAD groups (n = 1389). All patients underwent coronary computed tomographic angiography to evaluate coronary stenosis and coronary artery calcification (CAC). Spearman's tests were used to analyze the correlation between CAC score and LMR. Multivariate logistic regression models were set up to assess the risk factors of CAD. RESULTS:Patients with CAD had lower LMR value than patients without CAD (P = 0.001). LMR was negatively correlated with CAC score and was an independent risk factor of CAC score (P < 0.05). Multivariate logistic regression model showed that LMR ≤4.8 was a newly independent risk factor of CAD (all P < 0.05). Additionally, the new risk score model was compared with the Framingham model and showed that NRI was 4.9%, which proved that the new risk score model improved the prediction capability of CAD. CONCLUSION:LMR ≤4.8 is a new independent risk factor of CAD. LMR value was negatively correlated with CAC score and could be used as a new marker to evaluate the coronary plaque burden of CAD.
journal_name
Coron Artery Disjournal_title
Coronary artery diseaseauthors
Si Y,Liu J,Shan W,Zhang Y,Han C,Wang R,Sun Ldoi
10.1097/MCA.0000000000000857subject
Has Abstractpub_date
2020-11-01 00:00:00pages
650-655issue
7eissn
0954-6928issn
1473-5830journal_volume
31pub_type
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journal_title:Coronary artery disease
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journal_title:Coronary artery disease
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journal_title:Coronary artery disease
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journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
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journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
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journal_title:Coronary artery disease
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
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journal_title:Coronary artery disease
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journal_title:Coronary artery disease
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00019501-200007000-00008
更新日期:2000-07-01 00:00:00
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journal_title:Coronary artery disease
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doi:10.1097/00019501-200002000-00013
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pub_type: 杂志文章
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journal_title:Coronary artery disease
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doi:10.1097/00019501-199702000-00006
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