Association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease.

Abstract:

BACKGROUND:Lymphocyte-to-monocyte ratio (LMR) is involved in all stages of coronary atherosclerosis and related to coronary artery disease (CAD). However, the correlation between LMR and the coronary plaque burden of CAD is not clearly elucidated. Therefore, this study aimed to investigate their correlation in patients with CAD. METHODS:A total of 1953 consecutive eligible inpatients with suspected CAD were retrospectively included in this study. They were assigned into CAD (n = 564) and non-CAD groups (n = 1389). All patients underwent coronary computed tomographic angiography to evaluate coronary stenosis and coronary artery calcification (CAC). Spearman's tests were used to analyze the correlation between CAC score and LMR. Multivariate logistic regression models were set up to assess the risk factors of CAD. RESULTS:Patients with CAD had lower LMR value than patients without CAD (P = 0.001). LMR was negatively correlated with CAC score and was an independent risk factor of CAC score (P < 0.05). Multivariate logistic regression model showed that LMR ≤4.8 was a newly independent risk factor of CAD (all P < 0.05). Additionally, the new risk score model was compared with the Framingham model and showed that NRI was 4.9%, which proved that the new risk score model improved the prediction capability of CAD. CONCLUSION:LMR ≤4.8 is a new independent risk factor of CAD. LMR value was negatively correlated with CAC score and could be used as a new marker to evaluate the coronary plaque burden of CAD.

journal_name

Coron Artery Dis

journal_title

Coronary artery disease

authors

Si Y,Liu J,Shan W,Zhang Y,Han C,Wang R,Sun L

doi

10.1097/MCA.0000000000000857

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

650-655

issue

7

eissn

0954-6928

issn

1473-5830

journal_volume

31

pub_type

杂志文章
  • Long-term events after physician-referred initial tests by myocardial perfusion imaging or computed tomography coronary angiography in patients with suspected coronary artery disease.

    abstract:BACKGROUND:The effects of initial tests on long-term events have been unknown. PATIENTS AND METHODS:In this observational retrospective study, we analyzed the effects of initial noninvasive tests by myocardial perfusion imaging (MPI) and computed tomography angiography (CTA) on long-term major adverse cardiac events (...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCA.0000000000000645

    authors: Naya M,Uemura Y,Matsumoto N,Momose M,Kato T,Hida S,Yamauchi T,Nakajima T,Suzuki E,Tamaki N,J-COMPASS Extended Follow-Up Study Group.

    更新日期:2018-11-01 00:00:00

  • Decreased nitrate-mediated dilatation in patients with coronary artery ectasia: an ultrasonographic evaluation of brachial artery.

    abstract:BACKGROUND:Coronary artery ectasia has been defined as localized or diffuse nonobstructive lesions of the epicardial coronary arteries with a luminal dilation exceeding the 1.5-fold of normal adjacent segment or vessel diameter. Although coronary artery disease is supposed to be responsible for more than 50% of coronar...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200606000-00007

    authors: Aksoy Y,Acikgoz N,Sivri N,Bariskaner E,Akturk E,Turhan H,Yetkin E

    更新日期:2006-05-01 00:00:00

  • Circulating T-lymphocyte activation in patients with variant angina.

    abstract:BACKGROUND:Both experimental and pathological studies suggest that immune response and inflammation may play an important role in the pathogenesis of coronary spasm. DESIGN:To elucidate the role of systemic immune and inflammatory responses in the pathogenesis of coronary spasm, we studied circulating T-lymphocyte act...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200205000-00005

    authors: Terashima M,Akita H,Kanazawa K,Shiga N,Matsuda Y,Hirata K,Kawashima S,Yokoyama M

    更新日期:2002-05-01 00:00:00

  • Visual scoring of coronary artery calcification in lung cancer screening computed tomography: association with all-cause and cardiovascular mortality risk.

    abstract:OBJECTIVE:Current and former smokers are at an increased risk for lung cancer and cardiovascular disease (CVD). We investigated two methods of visual scoring of coronary artery calcium on lung cancer screening computed tomography (CT) to predict cardiovascular and all-cause mortality. PARTICIPANTS AND METHODS:Cases we...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000189

    authors: Watts JR Jr,Sonavane SK,Snell-Bergeon J,Nath H

    更新日期:2015-03-01 00:00:00

  • Long-term clinical impact of polymer-free sirolimus-eluting stents in unselected patients.

    abstract:OBJECTIVES:The long-term clinical impact of polymer-free sirolimus-eluting stents (PF-SES) in unselected patients undergoing percutaneous coronary intervention (PCI) still remains poorly investigated. We studied the long-term clinical impact of PF-SES in a large cohort of unselected patients receiving PCI therapy at tw...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCA.0000000000000378

    authors: Sinha N,Rai H,Cassese S,Kumar S,Kapoor A,Kastrati A

    更新日期:2016-08-01 00:00:00

  • Comparison of peripheral arterial tonometry and flow-mediated vasodilation for assessment of the severity and complexity of coronary artery disease.

    abstract:OBJECTIVE:Noninvasive flow-mediated vasodilation (FMD) is a widely used method to assess endothelial function, but its technical difficulty and problems remain obstacles for use in clinical practice. Reactive hyperemia-peripheral arterial tonometry (RH-PAT) was developed as a simpler and more reproducible method. We co...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000094

    authors: Woo JS,Jang WS,Kim HS,Lee JH,Choi EY,Kim JB,Kim WS,Kim KS,Kim W

    更新日期:2014-08-01 00:00:00

  • Comparison of 2-year outcomes of repeated second-generation drug-eluting stent implantation for focal-type versus nonfocal-type in-stent restenosis.

    abstract:BACKGROUND:Second-generation drug-eluting stents (DES) have been used widely to treat DES in-stent restenosis (ISR), which remains a clinical challenge. Knowledge of the outcomes of repeated second-generation DES implantation for focal versus nonfocal-type ISR is still missing. METHODS:In the current study, 254 patien...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000283

    authors: Zhu W,Li J,Luo H,Wang G,Hua Q

    更新日期:2015-11-01 00:00:00

  • Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study: rationale and design.

    abstract:BACKGROUND AND AIM:The association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCA.0000000000000546

    authors: Nakanishi R,Post WS,Osawa K,Jayawardena E,Kim M,Sheidaee N,Nezarat N,Rahmani S,Kim N,Hathiramani N,Susarla S,Palella F,Witt M,Blaha MJ,Brown TT,Kingsley L,Haberlen SA,Dailing C,Budoff MJ

    更新日期:2018-01-01 00:00:00

  • Extracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigs.

    abstract:OBJECTIVE:We have recently demonstrated that low-energy extracorporeal shock wave therapy improves chronic myocardial ischemia in pigs and humans. In this study, we examined whether our shock wave therapy is also effective at improving left ventricular remodeling after acute myocardial infarction in pigs. METHODS:Acut...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e328089f19b

    authors: Uwatoku T,Ito K,Abe K,Oi K,Hizume T,Sunagawa K,Shimokawa H

    更新日期:2007-08-01 00:00:00

  • Elderly patients with hypercholesterolaemia: a double-blind study of the efficacy, safety and tolerability of fluvastatin.

    abstract:BACKGROUND:Coronary heart disease is a major cause of morbidity and mortality in the elderly, a rapidly growing section of the population. Elderly patients have been excluded from most preventative risk factor trials. METHODS:We evaluated fluvastatin, a fully synthetic hydroxymethyl glutaryl coenzyme A reductase inhib...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Lye M,Valacio R,Reckless JP,Ghosh AK,Findlay IN,Ghosh MK,Passmore AP,Fulcher RA

    更新日期:1998-01-01 00:00:00

  • Can the risk for acute cardiac events in acute coronary syndrome be indicated by platelet membrane activation marker P-selectin?

    abstract:BACKGROUND:P-selectin, an adhesion molecule of the selectin family, is expressed on the surface of activated thrombocytes by thrombin. The aim of the present study was to assess the predictive value of P-selectin (estimated by flow cytometric assay) for acute cardiac events in acute coronary syndrome. METHODS:The stud...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199508000-00009

    authors: Itoh T,Nakai K,Ono M,Hiramori K

    更新日期:1995-08-01 00:00:00

  • The relative rapidity of recanalization induced by recombinant tissue-type plasminogen activator (r-tPA) and TNK-tPA, assessed with enzymatic methods.

    abstract:BACKGROUND:Comparison of different plasminogen activators is difficult because conventional endpoints such as mortality are relatively insensitive to potential differences in efficacy with respect to rapidity of recanalization of infarct-related arteries. METHODS:This study was performed to determine whether valid com...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00019501-200007000-00008

    authors: Binbrek A,Rao N,Absher PM,Van de Werf F,Sobel BE

    更新日期:2000-07-01 00:00:00

  • A brief review of the past and future of platelet P2Y12 antagonist.

    abstract::ADP plays a pivotal role in localized platelet activation and recruitment, and, with that, in the maintenance of thrombus integrity, making it a suitable target for the control of intravascular thrombosis. The limited distribution of one of its receptors, the P2Y12 receptor, primarily to platelets makes it an especial...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审

    doi:10.1097/MCA.0b013e3283564930

    authors: Barn K,Steinhubl SR

    更新日期:2012-09-01 00:00:00

  • Circulating adhesion molecules and severity of coronary atherosclerosis.

    abstract:BACKGROUND:Circulating leukocytes are recruited at atherosclerotic sites through a family of adhesion molecules. Circulating forms of adhesion molecules in peripheral blood can be quantified now. OBJECTIVE:To evaluate the relationship between circulating adhesion molecules and severity of coronary atherosclerosis. ME...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200002000-00013

    authors: Oishi Y,Wakatsuki T,Nishikado A,Oki T,Ito S

    更新日期:2000-02-01 00:00:00

  • Switching types of drug-eluting stents does not prevent repeated in-stent restenosis in patients with coronary drug-eluting stent restenosis.

    abstract:OBJECTIVES:We treated patients experiencing drug-eluting stent (DES) restenosis with plain old balloon angioplasty (POBA), implantation of the same type of DES [homogeneous drug-eluting stent (HOMO-DES)], or implantation of a different type of DES [heterogeneous drug-eluting stent (HETERO-DES)], and compared the effica...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000159

    authors: Nojima Y,Yasuoka Y,Kume K,Adachi H,Hattori S,Matsutera R,Kohama Y,Sasaki T

    更新日期:2014-12-01 00:00:00

  • Plaque composition and morphologic characteristics in significant left main bifurcation disease; virtual histology intravascular ultrasound study.

    abstract:OBJECTIVES:Although the left main coronary artery (LMCA) is clinically the most important site, little is known about the longitudinal plaque distribution and composition in the significant LMCA disease. METHODS:Preprocedure virtual histology intravascular ultrasound data were analyzed in 120 patients with significant...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000417

    authors: Chang M,Kang SJ,Yoon SH,Ahn JM,Park DW,Lee SW,Kim YH,Lee CW,Park SW,Nakazawa G,Mintz GS,Park SJ

    更新日期:2016-12-01 00:00:00

  • Single nucleotide polymorphisms associated with abnormal coronary microvascular function.

    abstract:BACKGROUND:Single nucleotide polymorphisms (SNPs) are the most common source of genetic variation. Although microvascular pathology is associated with cardiovascular events, genetic phenotypes causing microvascular disease remain largely unknown. This study identifies sex-specific SNPs associated with coronary microvas...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000104

    authors: Yoshino S,Cilluffo R,Best PJ,Atkinson EJ,Aoki T,Cunningham JM,de Andrade M,Choi BJ,Lerman LO,Lerman A

    更新日期:2014-06-01 00:00:00

  • Biomarker profiles as descriptors of left ventricular remodeling after acute myocardial infarction.

    abstract:BACKGROUND:Biomarker expression can predict subsequent cardiovascular events. The goal of this study was to determine the pattern of expression in blood of a broad array of cytokines and growth factors taken 24-72 h after an ST elevation myocardial infarction (STEMI) involving the left anterior descending (LAD) coronar...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e328346b88d

    authors: Lam PH,Anderson PR 3rd,Ahmed B,Sobel BE,Vanburen P,Schneider DJ

    更新日期:2011-08-01 00:00:00

  • The protection by ischemic preconditioning against myocardial ischemia- and reperfusion-induced arrhythmias is not mediated by ATP-sensitive potassium channels in rats.

    abstract:BACKGROUND:Single or multiple brief periods of myocardial ischemic preconditioning (PC) limits ischemia- and reperfusion-induced arrhythmias. This study tested whether PC protects against ischemia/reperfusion-induced arrhythmias and, if so, whether the protective effect was mediated by the opening of ATP-sensitive (KAT...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199307000-00010

    authors: Lu H,Remeysen P,De Clerck F

    更新日期:1993-07-01 00:00:00

  • Different impacts of C-reactive protein and lipid profile on coronary lesions following a percutaneous coronary intervention.

    abstract:OBJECTIVE:In-stent restenosis (ISR) and lesion progression are major obstacles for a percutaneous coronary intervention (PCI). Although previous studies have suggested that inflammation and lipid profile may be involved in those pathophysiological events, it remains controversial to date. The aim of the present study w...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e3283519f44

    authors: Xu HY,Qiao SB,Zhang JF,Dong QT,Li JJ

    更新日期:2012-05-01 00:00:00

  • Long-term effectiveness and safety of triple versus dual antiplatelet therapy after percutaneous coronary intervention for unprotected left main coronary artery disease.

    abstract:OBJECTIVES:We sought to compare the long-term effectiveness and safety of triple antiplatelet therapy (TAPT) versus dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) for unprotected left main coronary artery disease (uLMCAD). BACKGROUND:An additional strategy to reduce recurrent ischemia ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e328363abbd

    authors: Lee HJ,Yu CW,Hwang HK,Choi RK,Park JS,Li H,Ro YM

    更新日期:2013-11-01 00:00:00

  • Single-dose intramuscular administration of sustained-release Angiopeptin reduces neointimal hyperplasia in a porcine coronary in-stent restenosis model.

    abstract:BACKGROUND:In-stent restenosis results primarily from neointimal hyperplasia. In a previous study we showed that continuous subcutaneous Angiopeptin infusion for 1 week significantly reduces neointimal hyperplasia in a porcine coronary overstretch in-stent restenosis model. The present study evaluated the relative effi...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199702000-00006

    authors: Hong MK,Kent KM,Tio FO,Foegh M,Kornowski R,Bramwell O,Cathapermal SS,Leon MB

    更新日期:1997-02-01 00:00:00

  • Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction.

    abstract:OBJECTIVES:Red cell distribution width (RDW), a measure of red blood cell size heterogeneity, was evaluated in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). BACKGROUND:Higher RDW is associated with mortality in patients with symptomatic car...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e328342c77b

    authors: Uyarel H,Ergelen M,Cicek G,Kaya MG,Ayhan E,Turkkan C,Yıldırım E,Kırbas V,Onturk ET,Erer HB,Yesilcimen K,Gibson CM

    更新日期:2011-05-01 00:00:00

  • Attenuation of cardiac vascular rhexis: a promising therapeutic target.

    abstract:BACKGROUND:We have previously identified a phenomenon that we called vascular rhexis (VR) after coronary occlusion in mice. To explore its potential pathogenetic impact on the destruction of vessels described, its potential universality, and its characterization as a scaffolding for evaluating amelioration, we studied ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e32835d6688

    authors: Tarikuz Zaman AK,Spees JL,Sobel BE

    更新日期:2013-05-01 00:00:00

  • Predictors of atrial fibrillation after coronary artery bypass surgery.

    abstract:OBJECTIVE:Atrial fibrillation is one of the most common arrhythmias associated with not only increased morbidity after coronary artery bypass grafting but also increased healthcare costs. Many factors are associated with atrial fibrillation onset after coronary artery bypass grafting. We prospectively examined which fa...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e3281689a2c

    authors: Dogan SM,Buyukates M,Kandemir O,Aydin M,Gursurer M,Acikgoz S,Yavuzer R,Cam F,Dursun A

    更新日期:2007-08-01 00:00:00

  • Acute cardiorenal anemia syndrome among ST-elevation myocardial infarction patients treated by primary percutaneous intervention.

    abstract:BACKGROUND:Acute kidney injury (AKI) and anemia have been extensively studied in ST-elevation myocardial infarction (STEMI), yet the precise nature of their reciprocal relationship has not been elucidated in STEMI patients. METHODS:We performed a retrospective analysis of 2096 consecutive patients admitted for STEMI b...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000973

    authors: Merdler I,Loewenstein I,Zahler D,Levit D,Hochstadt A,Banai S,Gal-Oz A,Shacham Y

    更新日期:2020-10-13 00:00:00

  • Physical principles of magnetic resonance angiography.

    abstract::This review provides a brief introduction to the basic concepts of MRA techniques with specific discussions on imaging of coronary arteries. These techniques, especially those for imaging of coronary arteries, are still rapidly evolving. The goals of future research include obtaining faster imaging, higher SNR, and hi...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审

    doi:10.1097/00019501-199905000-00002

    authors: Li D

    更新日期:1999-05-01 00:00:00

  • The role of platelet inhibition in the drug-eluting stent era.

    abstract::The use of antiplatelet agents in the management of patients undergoing percutaneous coronary interventions involves the administration of aspirin, thienopyridines, and in high-risk patients, GPIIb-IIIa antagonists. Drug-eluting stents now account for greater than 50% of stenting procedures. This review focuses on the...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审

    doi:10.1097/00019501-200409000-00005

    authors: Tamberella MR,Furman MI

    更新日期:2004-09-01 00:00:00

  • Risk factors and comorbidities in a community-wide sample of patients hospitalized with acute systolic or diastolic heart failure: the Worcester Heart Failure Study.

    abstract:OBJECTIVES:Few epidemiological studies have examined differences in the prevalence of risk factors and comorbidities in patients with systolic heart failure (HF), as compared with those with diastolic HF. METHODS:We analyzed data from 1426 residents of the Worcester (MA) metropolitan area hospitalized at all 11 greate...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e328334eb46

    authors: Chinali M,Joffe SW,Aurigemma GP,Makam R,Meyer TE,Goldberg RJ

    更新日期:2010-05-01 00:00:00

  • On-line computerized vectorcardiography monitoring of myocardial ischemia during coronary angioplasty: comparison with 12-lead electrocardiography.

    abstract:BACKGROUND:With new interventions minimizing ischemic myocardial injury, accurate and reliable techniques for the detection and continuous monitoring of myocardial ischemia are essential. We compared two techniques used for the detection of myocardial ischemia during coronary angioplasty: on-line computerized vectorcar...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:

    authors: Jensen SM,Johansson G,Osterman G,Reiz S,Näslund U

    更新日期:1994-06-01 00:00:00