Neurofilament light and tau in serum after head-impact exposure in soccer.

Abstract:

:Introduction: Blood-based biomarkers can provide valuable information on the effects of repetitive head impacts in sports. This study investigated if repetitive headers or accidental head impacts in soccer could cause structural brain injury, detected as an increase in serum neurofilament light (NfL) or tau.Methods: NfL and tau were measured in professional soccer players in pre-season. Then, the effect of three short-term exposures on biomarker levels was assessed: (1) high-intensity exercise, (2) repetitive headers, and (3) head impacts in a match.Results: We analyzed 354 samples and observed no effects on NfL from any of the three short-term exposures. Tau levels rose significantly from baseline to 1 h after (1) high-intensity exercise (Δ0.50 pg/mL, 95% CI 0.19-0.81, p < .01); the same was observed after (2) repetitive headers (Δ0.29 pg/mL, 95% CI 0.10-0.48, p < .01), but not after (3) accidental head-impact incidents (Δ0.36 pg/mL, 95% CI -0.02-0.74, p = .06). The highest absolute values were seen 1 h after high-intensity exercise (mean±SD, 1.92 ± 0.83 pg/mL).Conclusion: NfL and tau in serum were unaffected by head impacts in soccer. Importantly, tau levels seem to rise in response to exercise, emphasizing the need for control groups. Our findings highlight important characteristics and limitations when using these biomarkers in sports.

journal_name

Brain Inj

journal_title

Brain injury

authors

Sandmo SB,Filipcik P,Cente M,Hanes J,Andersen TE,Straume-Naesheim TM,Bahr R

doi

10.1080/02699052.2020.1725129

subject

Has Abstract

pub_date

2020-04-15 00:00:00

pages

602-609

issue

5

eissn

0269-9052

issn

1362-301X

journal_volume

34

pub_type

杂志文章
  • Knowledge, attitudes, and behavior toward concussion in adult cyclists.

    abstract:OBJECTIVE:To determine knowledge, attitudes, and behavior toward concussion in cyclists and to identify predictors of concussion knowledge. METHODS:Cycling organizations sent members a web link to online information about the study and a questionnaire. Anyone aged >16 years, living in New Zealand and engaged in a cycl...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2020.1793386

    authors: O'Reilly M,Mahon S,Reid D,Hume P,Hardaker N,Theadom A

    更新日期:2020-07-28 00:00:00

  • Factor analysis of the adolescent version of the behavioural assessment screening tool (BAST-A) in adolescents with concussion.

    abstract::Objective: Develop and validate the Behavioral Assessment Screening Tool for Adolescents with brain injury. Setting: Concussion clinics Participants: Adolescents with mild traumatic brain injury 3 months after initial concussion clinic visit (n = 138). Design: Assessment development and validation (cross-sectional coh...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2020.1857838

    authors: B Juengst S,Kajankova M,Wright B,Terhorst L

    更新日期:2020-12-29 00:00:00

  • Pupillary responses to light in chronic non-blast-induced mTBI.

    abstract:PURPOSE:To evaluate objectively and quantitatively human pupillary responses to a light stimulus under photopic conditions in individuals with non-blast-induced, chronic, mild traumatic brain injury (mTBI). METHODS:Seventeen individuals with chronic, non-blast-induced mTBI and 15 visually-normal (VN) controls were tes...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2015.1045029

    authors: Thiagarajan P,Ciuffreda KJ

    更新日期:2015-01-01 00:00:00

  • Driving after brain injury: self-awareness and coping at the tactical level of control.

    abstract:OBJECTIVE:To study whether metacognition is a prerequisite for coping at the tactical level of driving. RESEARCH DESIGN:A consecutive series of 30 drivers with acquired brain injury were assessed concerning cognitive functions and driving performance. In addition the drivers assessed their driving performance through ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050701651660

    authors: Lundqvist A,Alinder J

    更新日期:2007-10-01 00:00:00

  • Conversation-based assessment of social cognition in adults with traumatic brain injury.

    abstract:PRIMARY OBJECTIVE:The purpose of this study was to characterize performance of individuals with traumatic brain injury (TBI) on a novel video-based test, the Video Social Inference Test (VSIT). The VSIT was designed to capture social inference processes that would be engaged in daily conversations. The test required bo...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050802027059

    authors: Turkstra LS

    更新日期:2008-05-01 00:00:00

  • Parental alcohol misuse is a powerful predictor for the risk of traumatic brain injury in childhood.

    abstract:BACKGROUND:Although the positive relationship between parental alcohol use and children's injuries is well established, it is not known whether parental alcohol misuse is a risk factor for traumatic brain injuries (TBIs) of their children and whether subjects with childhood TBI have hazardous drinking habits in adolesc...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050701553221

    authors: Winqvist S,Jokelainen J,Luukinen H,Hillbom M

    更新日期:2007-09-01 00:00:00

  • Semantic memory impairments following non-progressive brain injury: a study of four cases.

    abstract::Four brain-injured subjects with semantic memory impairments are described. Two had sustained traumatic head injury and two had herpes simplex virus encephalitis. The study seeks to determine (a) whether subjects with non-progressive brain injury and impaired semantic memory perform similarly to patients with progress...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990597123566

    authors: Wilson BA

    更新日期:1997-04-01 00:00:00

  • Intonation unit analysis of conversational discourse in closed head injury.

    abstract::This study employed a modification of the intonation unit analysis for conversational discourse developed by Mentis and Prutting. The percentage of total intonation units produced within separate ideational categories was calculated for groups of closed head-injured and normal control subjects as well as the examiner....

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990599121700

    authors: Wozniak RJ,Coelho CA,Duffy RJ,Liles BZ

    更新日期:1999-03-01 00:00:00

  • Does intervention using virtual reality improve upper limb function in children with neurological impairment: a systematic review of the evidence.

    abstract:BACKGROUND:Virtual reality (VR) is an emerging area of paediatric clinical and research practice, however the majority of research to date has focused on outcomes for adults following stroke. This paper appraises and describes current evidence for use of virtual reality interventions to improve upper limb function of c...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.3109/02699052.2011.558047

    authors: Galvin J,McDonald R,Catroppa C,Anderson V

    更新日期:2011-01-01 00:00:00

  • Intravenous saline administration in patients with severe acquired brain injury and orthostatic intolerance for tilt-table mobilization.

    abstract:PRIMARY OBJECTIVE:This study aimed to investigate the effect of intravenous saline administration on orthostatic hypotension (OH) during head up tilt (HUT) and the change in the renin-angiotensin-aldosterone system before and after HUT in patients with severe acquired brain injury (ABI). RESEARCH DESIGN:The study is d...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2017.1408144

    authors: Riberholt C,Olesen N,Hovind P,Mehlsen J,Petersen TH

    更新日期:2018-01-01 00:00:00

  • The disablement experienced by traumatically brain-injured adults living in the community.

    abstract::The disablement that occurs following traumatic brain injury (TBI) can be extensive and severe and consequently has been difficult to report on in a comprehensive and thorough manner. We were able to address this difficulty by analysing a sub group of data from the Canadian Health and Activity Limitation Survey (HALS)...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699059509005774

    authors: Dawson DR,Chipman M

    更新日期:1995-05-01 00:00:00

  • Subjective outcome of brain injury rehabilitation in relation to the therapeutic working alliance, client compliance and awareness.

    abstract:OBJECTIVE:To investigate the relationship between working alliance, compliance, awareness and subjective outcome of brain injury rehabilitation. Subjects were 86 patients who were clients in an holistic neuropsychological outpatient rehabilitation programme. They had suffered a traumatic brain injury (n = 27), a cerebr...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050601049395

    authors: Schönberger M,Humle F,Teasdale TW

    更新日期:2006-11-01 00:00:00

  • Vestibular consequences of mild traumatic brain injury and blast exposure: a review.

    abstract::The purpose of this article is to review relevant literature on the effect of mild traumatic brain injury (mTBI) and blast injury on the vestibular system. Dizziness and imbalance are common sequelae associated with mTBI, and in some individuals, these symptoms may last for six months or longer. In war-related injurie...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.1080/02699052.2017.1288928

    authors: Akin FW,Murnane OD,Hall CD,Riska KM

    更新日期:2017-01-01 00:00:00

  • Latent structure of the Test of Everyday Attention: convergent evidence from patients with traumatic brain injury.

    abstract:AIM:The present study aimed to examine the nature of attention distinctions among sub-tests of the Test of Everyday Attention (TEA) underlying the performance of patients with traumatic brain injury (TBI). METHOD:Confirmatory factor analysis was performed among a group of 92 patients with TBI experiencing chronic post...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050600676974

    authors: Chan RC,Lai MK

    更新日期:2006-06-01 00:00:00

  • Psychometric properties of the simple test for evaluating hand function in patients with stroke.

    abstract:OBJECTIVE:The simple test for evaluating hand function (STEF) is widely used for clinical evaluation of upper extremity function in Japan. However, except for test-re-test reliability, its psychometric properties have not been investigated. The aim of this study is to explore its internal consistency, concurrent validi...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2015.1004740

    authors: Shindo K,Oba H,Hara J,Ito M,Hotta F,Liu M

    更新日期:2015-01-01 00:00:00

  • The experience of being a parent with an acquired brain injury (ABI) as an inpatient at a neuro-rehabilitation centre, 0-2 years post-injury.

    abstract:PRIMARY OBJECTIVE:Little research has been conducted exploring the issues surrounding parenting with an acquired brain injury (ABI). This study aimed to explore the experiences and needs of parents who suffered an ABI in the last 2 years from their own perspectives. For individuals with an ABI who have dependent childr...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2014.947633

    authors: Edwards AR,Daisley A,Newby G

    更新日期:2014-01-01 00:00:00

  • A proposal for an evidenced-based emergency department discharge form for mild traumatic brain injury.

    abstract:PRIMARY OBJECTIVE:To examine and compare a sample of head injury care instruction forms available in hospital emergency departments (EDs) against evidence-based factors predictive of haemorrhage or traumatic lesions and to propose an easy-to-understand discharge instruction form for patients with concussion or mild tra...

    journal_title:Brain injury

    pub_type: 杂志文章,多中心研究,评审

    doi:10.1080/02699050600831934

    authors: Fung M,Willer B,Moreland D,Leddy JJ

    更新日期:2006-08-01 00:00:00

  • Multiple indicators model of long-term mortality in traumatic brain injury.

    abstract:OBJECTIVE:To examine the prognostic ability of protein S100B, neuron-specific enolase (NSE) and glial fibrillary acid protein (GFAP) for prediction of 1-year mortality in patients with traumatic brain injury (TBI) in relation to clinical and radiological characteristics of TBI. METHODS:Brain injury was quantified in 8...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2012.694567

    authors: Gradisek P,Osredkar J,Korsic M,Kremzar B

    更新日期:2012-01-01 00:00:00

  • Predictive value of initial intracranial pressure for refractory intracranial hypertension in persons with traumatic brain injury: a prospective observational study.

    abstract:UNLABELLED:Abstract Objective: To prospectively investigate the predictive value of initial intracranial pressure (ICP) for refractory intracranial hypertension and outcomes in persons with diffuse traumatic brain injury (TBI). METHODS:A prospective observational study was conducted in 107 adult persons with diffuse T...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2013.775497

    authors: Yuan Q,Liu H,Wu X,Sun Y,Zhou L,Hu J

    更新日期:2013-06-01 00:00:00

  • Impact of skull fracture on neuropsychological functioning following closed head injury.

    abstract::The role of skull fracture in affecting morbidity following closed head injury (CHI) has received a significant amount of attention from researchers. While there is fairly widespread agreement that skull fractures increase the risk of complications such as haematoma, it us unclear whether the presence of skull fractur...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990597123638

    authors: Smith-Seemiller L,Lovell MR,Smith S,Markosian N,Townsend RN

    更新日期:1997-03-01 00:00:00

  • Service needs and barriers to care five or more years after moderate to severe TBI among Veterans.

    abstract:PRIMARY OBJECTIVE:The objective of this paper is to identify the most frequent service needs, factors associated with needs, and barriers to care among Veterans and service members five or more years after moderate to severe traumatic brain injury (TBI). RESEARCH DESIGN:Survey administered via telephone 5-16 years aft...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2017.1307449

    authors: Schulz-Heik RJ,Poole JH,Dahdah MN,Sullivan C,Adamson MM,Date ES,Salerno R,Schwab K,Harris O

    更新日期:2017-01-01 00:00:00

  • A new global health outcome score after trauma (GHOST) for disability, cognitive impairment, and health-related quality of life: data from a prospective cross-sectional observational study.

    abstract::Background:Trauma patients experience morbidity related to disability and cognitive impairment that negatively impact their health-related quality of life (HRQoL). We assessed the impact of trauma on disability, cognitive impairment and HRQoL after intensive care in patients with and without traumatic brain injury (TB...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2019.1581257

    authors: Berger-Estilita J,Granja C,Gonçalves H,Dias CC,Aragão I,Costa-Pereira A,Orwelius L

    更新日期:2019-01-01 00:00:00

  • "Just got to live life as it comes": A case study of the spousal-dyad longitudinal mild stroke transitional experience.

    abstract::Objective: To longitudinally explore the transition home for a spousal dyad following mild stroke, in the context of a mild stroke-specific health service. Research Design: A case study approach, using an Interpretative Phenomenological Analysis (IPA), was identified as suitable for this study, as it enabled the essen...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2019.1629625

    authors: Hodson T,Gustafsson L,Cornwell P

    更新日期:2019-01-01 00:00:00

  • The use of cranial electrotherapy stimulation in the treatment of closed-head-injured patients.

    abstract::This double-blind study sought to discover if cranial electrotherapy stimulation (CES), which is a known treatment of depression, anxiety and insomnia in non-head-injured patients, could be an effective, drug-free treatment of stress-related symptoms in the closed-head-injured (CHI) patient. In this study 10 CHI patie...

    journal_title:Brain injury

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/02699059409150986

    authors: Smith RB,Tiberi A,Marshall J

    更新日期:1994-05-01 00:00:00

  • S100B serum protein cannot predict secondary intracranial haemorrhage after mild head injury in patients with low-dose acetylsalicylic acid prophylaxis.

    abstract:INTRODUCTION:The goal of this study was to investigate if S100B serum protein could predict secondary intracranial haemorrhagic events (SIHEs) after mild head injury (mHI) in patients taking low-dose acetylsalicylic acid (LDA), making routinely repeated head computed tomography (RRHCT) scans unnecessary. METHODS:Three...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2015.1087593

    authors: Ernstbrunner L,Korn G,Ernstbrunner E,Auffarth A,Tauber M,Resch H,Moroder P

    更新日期:2016-01-01 00:00:00

  • Community re-entry of long-term institutionalized brain-injured persons.

    abstract::Although evidence exists for delayed recovery after traumatic brain injury, patients who do not receive rehabilitation early after their injuries often remain permanently in long-term care facilities. Case reports of five severely brain-injured persons who were discharged into long-term nursing care facilities for at ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699059509008201

    authors: Bell KR,Tallman CA

    更新日期:1995-04-01 00:00:00

  • Social competence and head injury: a new emphasis.

    abstract::In the push for quantifiable outcome-based rehabilitation programmes, sensitivity to the integrity and uniqueness of the individual has been moved to the background. This has been particularly noticeable in the area of social skills therapy for persons who have suffered a traumatic head injury. We review some of the p...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.3109/02699059509004575

    authors: McGann W,Werven G

    更新日期:1995-01-01 00:00:00

  • Static and dynamic assessment practices after head injury.

    abstract::Many individuals suffer acquired brain injury (ABI) each year. This impacts on the need for rehabilitation supports and services that facilitate the achievement of personal goals. The role of assessment in the rehabilitation of people with ABI is examined. The extent to which assessment practices match (in any way) no...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990596124421

    authors: Rees RJ,Storry CJ

    更新日期:1996-04-01 00:00:00

  • Seeing minds in patients with disorders of consciousness.

    abstract::Objective: To explore the ways in which health care professionals and families understand terms and concepts associated with disorders of consciousness.Methods: Open-ended, semi-structured interviews were conducted with 20 health care professionals and 18 family caregivers affiliated with a disorders of consciousness ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2019.1706000

    authors: Peterson A,Kostick KM,O'Brien KA,Blumenthal-Barby J

    更新日期:2020-02-23 00:00:00

  • The Immediate Post-Concussion Assessment and Cognitive Testing battery and traditional neuropsychological measures: a construct and concurrent validity study.

    abstract:PRIMARY OBJECTIVE:This study examined the construct and concurrent validity of ImPACT, a computerized neuropsychological test battery used for evaluating sports-related concussion. RESEARCH DESIGN:Approximately 100 neurologically intact undergraduates completed ImPACT and a battery of traditional neuropsychological te...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2010.541897

    authors: Allen BJ,Gfeller JD

    更新日期:2011-01-01 00:00:00