Resolution of opioid-induced postoperative ileus in a newborn infant after methylnaltrexone.

Abstract:

:Transient impairment of bowel function is a frequent and distressing problem in neonates on opioid-induced analgesia. Methylnaltrexone, a peripheral-acting μ-opioid receptor antagonist, has been studied in adults for the treatment of opioid-induced constipation in advanced illness and has been suggested as a promising therapeutic concept for reducing postoperative ileus. Here, we report on a newborn infant on fentanyl analgesia after major abdominal surgery with aggravated ileus. After 8 days of quiescent bowel, the patient's intestinal dysmotility resolved within 15 minutes after intravenous administration of methylnaltrexone (0.15 mg/kg body weight). Methylnatrexone was repeated daily until cessation of fentanyl administration. There were no signs of pain or opioid withdrawal.

journal_name

J Pediatr Surg

authors

Garten L,Degenhardt P,Bührer C

doi

10.1016/j.jpedsurg.2010.10.015

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

e13-5

issue

3

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(10)00978-4

journal_volume

46

pub_type

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