[Use of cycloferon in the treatment of patients with pulmonary tuberculosis with mild clinical manifestations].

Abstract:

AIM:to evaluate the efficacy of cyclopheron used in patients with mild clinical manifestations of focal and infiltrative pulmonary tuberculosis (PT). SUBJECTS AND METHODS:Thirty first detected patients with PT, in whom a complex of their etiotropic therapy comprised cyclopheron, and 32 similar patients who received etiotropic agents and placebo were examined. Tuberculosis process activity was confirmed by clinical, X-ray, bacteriological, and immunological studies. The hypothalamic-pituitary-adrenal system was determined from serum cortisol concentration. The sympathoadrenal system was assessed from cardiac rhythm parameters (autonomic balance index). RESULTS:Incorporation of cyclopheron into the combined therapy of patients with PT led to increased blood cortisol concentration, higher autonomic balance index, elevated T-lymphocyte count, enhanced phagocytic activity, and lower levels of circulating immune complexes, resulting in earlier decay cavity closure and sputum negativation. CONCLUSION:Extrastress status of adaptation systems and the absence of their activating impact on immunity and inflammation are detectable in first detected patients with mild clinical manifestations of PT running in significant lung tissue fibrosis. Therapy with cyclopheron that stimulates the production of stress-induced cytokines gives rise to a stress reaction, activates immune processes, and enhances therapeutic effectiveness in this group of patients.

journal_name

Ter Arkh

journal_title

Terapevticheskii arkhiv

authors

Filippova TP,Vasil'eva LS,Kochkin AV

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

49-53

issue

11

eissn

0040-3660

issn

2309-5342

journal_volume

82

pub_type

杂志文章,随机对照试验
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    authors: Botsvadze ESh,Aleksishvili MM,Gegeshidze TN,Mosakhlishvili NG

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    authors: Landyshev SIu,Borodin EA

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  • [Acute hemodynamic effects of finoptin in patients with bronchial asthma complicated by pulmonary hypertension].

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    authors: Brimkulov NN

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  • [Prognostic value of a focal bone marrow lesion in diffuse large B-cell lymphosarcoma].

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  • [A current model for predicting the risk of cardiovascular diseases in patients with type 2 diabetes mellitus].

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  • [Peritoneal macrophages as a model for the study of the atherogenic potential of the blood serum].

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  • [The evolution of juvenile systemic scleroderma].

    abstract::60 cases of scleroderma systematica with onset in the childhood or adolescence have been analyzed. Juvenile scleroderma took, as a rule, a favourable course (78%). Slow progression was observed in 43% of patients. Stabilization occurred in 20% of cases. A complete regression was seen in 15%. The disease ran unfavorabl...

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  • [Myocardial electrical activity and hemodynamic indices in the early stage of the rehabilitation of myocardial infarct patients].

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  • [Clinico-psychological features of patients with angina pectoris and obesity].

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  • [The effect of therapeutic plasmapheresis on changes in the rheological properties of the blood in bronchial asthma patients].

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  • [Thrombotic microangiopathy in rheumatology: a link between thrombosis and autoimmunity].

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  • [Hepatitis B virus infection and glomerulonephritis].

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  • [Biliary tract in patients with chronic viral hepatitides].

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  • [Characteristics of blood pressure in schoolchildren 7-17 years old (based on one-stage and prospective studies)].

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    pub_type: 杂志文章

    doi:

    authors: Tubol IB,Il'chenko IN,Akhmeteli MA,Zhukovskiĭ GS,Burlutskiĭ GI

    更新日期:1984-01-01 00:00:00

  • [Metabolic effects of intermittent hemofiltration in patients with acute renal failure].

    abstract:AIM:Investigation of postaggressive reaction of metabolism on intermitten hemofiltration (IHF) in patients with acute renal failure (ARF). The speed of generation of urea, creatinine and oligopeptides was estimated in the course of (IHF) and in interval between the procedures. Hormonal stress was evaluated by concentra...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

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  • [Optimizing the prophylaxis of hospital-acquired deep vein thrombosis and pulmonary thromboembolism].

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    pub_type: 杂志文章

    doi:

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  • [Pharmacotherapy for rheumatoid arthritis in the early 21st century: Russian and international experience].

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    doi:

    authors: Nasonov EL,Karateev DE,Lukina GV

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  • [Diagnostic laparoscopy in hematologic patients].

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    pub_type: 杂志文章

    doi:

    authors: Fadeev OA,Kaplanskaia IB,Klimanskiĭ VA

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