Abstract:
AIM:to evaluate the efficacy of cyclopheron used in patients with mild clinical manifestations of focal and infiltrative pulmonary tuberculosis (PT). SUBJECTS AND METHODS:Thirty first detected patients with PT, in whom a complex of their etiotropic therapy comprised cyclopheron, and 32 similar patients who received etiotropic agents and placebo were examined. Tuberculosis process activity was confirmed by clinical, X-ray, bacteriological, and immunological studies. The hypothalamic-pituitary-adrenal system was determined from serum cortisol concentration. The sympathoadrenal system was assessed from cardiac rhythm parameters (autonomic balance index). RESULTS:Incorporation of cyclopheron into the combined therapy of patients with PT led to increased blood cortisol concentration, higher autonomic balance index, elevated T-lymphocyte count, enhanced phagocytic activity, and lower levels of circulating immune complexes, resulting in earlier decay cavity closure and sputum negativation. CONCLUSION:Extrastress status of adaptation systems and the absence of their activating impact on immunity and inflammation are detectable in first detected patients with mild clinical manifestations of PT running in significant lung tissue fibrosis. Therapy with cyclopheron that stimulates the production of stress-induced cytokines gives rise to a stress reaction, activates immune processes, and enhances therapeutic effectiveness in this group of patients.
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Filippova TP,Vasil'eva LS,Kochkin AVsubject
Has Abstractpub_date
2010-01-01 00:00:00pages
49-53issue
11eissn
0040-3660issn
2309-5342journal_volume
82pub_type
杂志文章,随机对照试验abstract::Granulomatosis with polyangiitis (GPA), formerly earlier known as Wegener's granulomatosis, is primary system necrotizing vasculitis of small and medium-sized vessels, which is characterized by the formation of foci of granulomatous inflammation. One of the target organs in GPA is the organ of vision. Its affection ma...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章,评审
doi:10.17116/terarkh20158712111-116
更新日期:2015-01-01 00:00:00
abstract::A study was made of HB-virus infection markers in 438 patients of different age with hepatitis B. Highly sensitive methods based on the test systems manufactured in this country and abroad were employed. The authors established the diagnostic importance of HBV markers, studied the prevalence of those markers in parent...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::The paper provides a review of the literature on a relevant non-drug prevention problem, namely the negative effect of trans isomers of unsaturated fatty acids (trans-UFA) on the risk of circulatory system diseases (CSD) and other chronic noncommunicable diseases. It gives data on the specific features of the structur...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章,评审
doi:
更新日期:2013-01-01 00:00:00
abstract::Some molecular and cellular mechanisms of compensation for respiratory failure (RF) were examined in 90 patients with nonspecific pulmonary diseases. In acute RF, the content of 2,3-DPH in red blood cells was increased. As RF progressed, the compensatory-adaptation reaction became less marked. In chronic RF, the 2,3-D...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::External respiration, circulation and gas exchange trends were investigated in acute pneumonia convalescents followed up on an outpatient basis. It was found that 72% of patients admitted to hospital for acute pneumonia, upon discharge demonstrated residual clinicoroentgenological effects. Cardiorespiratory distress, ...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::The authors describe the results of a study into antioxidants (superoxide dismutase and catalase) and production of the active forms of oxygen (superoxide anion radical, hydrogen peroxide, hydroxyl radical, and singlet oxygen) by blood and bone marrow leukocytes from patients with Fanconi's anemia. The generation of t...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract:AIM:The retrospective analysis of prevalence, peculiarities of duration of biliary calculosis without gall bladder cholesterosis, biliary calculosis with gall-bladder cholesterosis and xanthogranulematous cholecystitis among persons who underwent cholecystectomy using clinical, instrumental and morphological data. MATE...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract:AIM:to compare respiratory function and laboratory data with the radiographic stages of intrathoracic sarcoidosis. SUBJECTS AND METHODS:Three hundred and eleven patients (70.4% for women and 29.6% for men; mean age, 44.7±0.6 years) with histologically verified sarcoidosis underwent X-ray computed tomography, spirograp...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:10.17116/terarkh201587348-52
更新日期:2015-01-01 00:00:00
abstract::The effect of i. v. verapamil administration on some indices of the hemodynamics of the greater and lesser circulation was studied in 19 patients with bronchial asthma by a multiple approach using noninvasive methods (rheopulmonography, polycardiography, tetrapolar chest rheography). A decrease in the systemic as well...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract:AIM:To study prognostic implications of a focal mature cell lesion of the bone marrow (BM) in patients with diffuse large B cell lymphosarcoma (DBLCL). MATERIAL AND METHODS:54 patients with histologically confirmed DBLCL were given first-line CHOP and CHOP-like courses from 1996 to 2003. B-cell nature of the tumor was...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is a severe progressive disease complicating the development of micro- and macrovascular complications that result in early disability, including that in able-bodied persons, a reduction in the patients' life, and its worse quality. The author discusses the new scale developed according...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章,评审
doi:
更新日期:2012-01-01 00:00:00
abstract:AIM:To characterize correlations between the levels of vitamin D, parathormone, calcium, blood phosphates in patients with different stages of chronic disease of the kidney (CDK) given no therapy replacing renal function (TRRF). MATERIAL AND METHODS:Serum levels of creatinine, electrolytes, parathormone (PTH), 25(OH)-...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract:AIM:To investigate the AGTR1 A/C polymorphism associated with atrial fibrillation (AF) to form risk groups among patients who are prone to this disease. SUBJECTS AND METHODS:90 probands with a confirmed diagnosis of AF and their 144 first-, second-, and third-degree relatives were examined. These families made up a st...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:10.17116/terarkh201789948-52
更新日期:2017-01-01 00:00:00
abstract:AIM:The aim of the study is to determine the prevalence of AO in the population and to assess the association with socioeconomic factors according to the data of the ESSE-RF study (Epidemiology of Cardiovascular diseases in the Regions of the Russian Federation). MATERIALS AND METHODS:The object of the study is a rand...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:10.26442/terarkh2018901014-22
更新日期:2018-11-22 00:00:00
abstract::A study was made of the capacity of peritoneal macrophages to demonstrate the atherogenic potential of blood serum. Murine and human macrophages were found to be capable of intracellular accumulation of cholesterol during cultivation with blood sera from patients with coronary atherosclerosis. The data on the capacity...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::60 cases of scleroderma systematica with onset in the childhood or adolescence have been analyzed. Juvenile scleroderma took, as a rule, a favourable course (78%). Slow progression was observed in 43% of patients. Stabilization occurred in 20% of cases. A complete regression was seen in 15%. The disease ran unfavorabl...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Available indirect methods were employed to examine 52 patients with a history of myocardial infarction and 18 normal subjects by the end of the early rehabilitation period. Hemodynamic overload of the left atrium was revealed. The main hemodynamic parameters and processes marking contractile and electrical myocardial...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract:AIM:To study clinical and psychological features of patients with coronary heart disease (CHD) and their comparison with obesity. MATERIALS AND METHODS:The presence and intensity of cardialgia, Ketle's index, body mass fat component, tolerance to isometric load were determined in 104 patients with stable angina of eff...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Bronchial asthma runs its course in association with marked blood viscosity which lies in a decrease of deformability of red blood cells and suspension stability of red blood cells, an increase of their aggregation capacity and of whole blood viscosity, of platelet proneness to decelerated and little noticeable aggreg...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Uncontrolled hypercoagulation and inflammation (thromboinflammation), which are both independent and closely related and amplifying each other pathological processes, form the basis for pathogenesis of a wide range of diseases and complications, including immuno-inflammatory (autoimmune) rheumatic diseases, with the d...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:10.26442/00403660.2020.05.000697
更新日期:2020-06-05 00:00:00
abstract::Thyroid cancer is the most common malignant tumor of the endocrine system. An increase in the incidence of thyroid cancer has been noted over the past decade, mainly due to papillary cancer. The influence of environmental factors, increased availability of medical care, including sensitive diagnostic tests, such as ul...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:10.26442/00403660.2019.10.000357
更新日期:2019-10-15 00:00:00
abstract::HBsAg was detected in the blood serum of patients with glomerulonephritis (GN) in 21.1% of cases. During examination of patients with other diseases of the kidneys HBsAg was detected in the blood serum much less frequently (8.3%). In patients with systemic autoimmune diseases it was found in 12.1%, in patients with py...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract:AIM:To study an association between iron metabolism, free radical oxidation (FRO), and antioxidative system (AOS) in patients with acute myeloid leukemia (AML) during intensive chemotherapy. SUBJECTS AND METHODS:AML patients (n = 14) with a median age of 46 years received 7+3 courses (n = 3) containing cytarabine > or...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
abstract:AIM:To characterize motor-kinetic and inflammatory changes in extrahepatic biliary tracts and gallbladder in patients with chronic viral hepatitis (CVH). To ascertain whether there is a pathogenetic correlation between affection of the biliary system and viral infection. MATERIAL AND METHODS:The condition of the bilia...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::One-stage epidemiological survey permitted one to define the limits of normal blood pressure values in schoolchildren aged 7-17 years for each age-sexual group differentially. Isolated blood pressure elevation was found to be rare, amounting to 4.4% in boys and to 3.1% in girls. The rate of new cases of elevated blood...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract:AIM:Investigation of postaggressive reaction of metabolism on intermitten hemofiltration (IHF) in patients with acute renal failure (ARF). The speed of generation of urea, creatinine and oligopeptides was estimated in the course of (IHF) and in interval between the procedures. Hormonal stress was evaluated by concentra...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract:AIM:To reduce the number of preventable hospital-acquired venous thromboembolic events (HA-VTE) and to improve the quality of VTE prophylaxis at multiprofile hospital. MATERIAL AND METHODS:A comprehensive approach to preventing HA-VTE was developed, which involved the global trigger tool method to assess adverse event...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:10.17116/terarkh201688923-30
更新日期:2016-01-01 00:00:00
abstract::The study included 30 IHD patients with primary hypercholesterolemia (22 males and 8 females). 18 and 12 patients have received a single daily dose of fluvastatin 20 and 40 mg, respectively, in the evening for 12 weeks. The drug effect was assessed by changes in the clinical status, lipid spectrum, transport-metabolic...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::The paper summarizes the data of international and Russian studies concerning current approaches to the pharmacotherapy of rheumatoid arthritis. Particular emphasis is placed on the substantiation of the treat-to-target concept, on the efficacy and safety of genetically engineered biological agents, including the inhi...
journal_title:Terapevticheskii arkhiv
pub_type: 历史文章,杂志文章,评审
doi:
更新日期:2013-01-01 00:00:00
abstract::The authors analyze indications, technique and results of 143 laparoscopies in blood diseases and diseases with hematological symptoms; evidence obtained at combined and separate hepatic and splenic biopsies (55, 84 and 1 patients, respectively). Trepan biopsy was preferred to other biopsies. The technique proposed by...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00