Abstract:
BACKGROUND:Airway remodeling refers to the structural changes in the airways of asthma. Caveolin-1 reduces cell growth and negatively regulates smooth muscle cell proliferation. The aim was to investigate lung caveolin-1 status in a murine model of acute allergic airway disease. METHODS:Six- to eight-week-old female BALB/c mice were sensitized by intraperitoneal injections of phosphate-buffered saline or ovalbumin (OVA) and aluminium hydroxide on Days 0 and 14, challenged with aerosolized saline or OVA (1%) on Days 21-25, 28-32, and 35. The mice were killed 1 day after the last OVA/saline challenge. Serum OVA-specific immunoglobulin E (IgE) was measured by enzyme-linked immunosorbent assay. Peribronchial inflammation was quantified by morphometric analysis. Lung caveolin-1 and Type I collagen mRNA expression was determined by real-time reverse-transcription polymerase chain reaction. Total lung collagen was measured using Sircol Assay Kit. RESULTS:Serum OVA-specific IgE levels were significantly elevated in OVA-challenged mice when compared with saline-challenged mice. Percentage of inflammatory cells in the bronchoalveolar lavage was significantly higher in the OVA-challenged animals. The animals' lungs that were sensitized and challenged with OVA contained large numbers of inflammatory cells concentrated near the airways and in the perivascular areas. The thickness of the bronchial epithelial layer and smooth muscle layer and the numbers of total inflammatory cells and eosinophils significantly increased in OVA-challenged mice. Caveolin-1 mRNA expression significantly decreased and Type I collagen mRNA expression significantly increased in the lung tissue of OVA-challenged mice. CONCLUSION:These results suggest that caveolin-1 seems to be involved in the pathogenesis of airway remodeling of acute allergic airway disease.
journal_name
Pediatr Neonatoljournal_title
Pediatrics and neonatologyauthors
Chen CM,Wu MY,Chou HC,Lang YD,Wang LFdoi
10.1016/j.pedneo.2010.12.006subject
Has Abstractpub_date
2011-02-01 00:00:00pages
5-10issue
1eissn
1875-9572issn
2212-1692pii
S1875-9572(10)00014-8journal_volume
52pub_type
杂志文章abstract:BACKGROUND:Little is known about the characteristics of patients who visit the emergency department (ED) due to food allergy in Taiwan. This study aims to assess the triggers, clinical presentations, and management of patients presenting to a tertiary ED for food allergy. METHODS:This is a retrospective study of 369 v...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2013.11.006
更新日期:2014-08-01 00:00:00
abstract::Interstitial deletion of the proximal short arm of chromosome 4 has rarely been described. This defect is associated with variable clinical manifestations, including mental retardation, unusual facial appearance, and minor limb abnormalities. We describe a girl diagnosed with moderate mental retardation and seizures w...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2011.03.009
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abstract:BACKGROUND:Neonates with a single umbilical artery (SUA) are considered at increased risk for chromosomal and structural abnormalities, and an increased adverse perinatal outcome. OBJECTIVE:The specific aims of our study were to evaluate (1) the association of asymptomatic infants with isolated SUA and perinatal outco...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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abstract:BACKGROUND:Meconium peritonitis (MP) develops when bowel perforation occurs in utero or soon after birth, resulting in leakage of meconium into the peritoneal cavity. The clinical features are often variable and prenatal ultrasonography plays an important role in prenatal diagnosis. METHODS:We conducted a retrospectiv...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/s1875-9572(09)60034-6
更新日期:2009-04-01 00:00:00
abstract::Pediatric cardiomyopathies are a group of myocardial diseases with complex taxonomies. Cardiomyopathy can occur in children at any age, and it is a common cause of heart failure and heart transplantation in children. The incidence of pediatric cardiomyopathy is increasing with time. They may be associated with variabl...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章,评审
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abstract:BACKGROUND:The study of genetic polymorphisms of surfactant-lipids related genes can help to understand individual variability in the susceptibility to development of pulmonary pathologies. The purpose of this study was to evaluate the association of polymorphisms of surfactant-lipids related genes (LPCAT1, CHPT1 and P...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2019.12.012
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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abstract:BACKGROUND:The parameters of oxidative stress [advanced oxidation protein products (AOPPs), malondialdehyde (MDA), and S100B] and the effect of intensive phototherapy (PT) on these parameters have not been studied extensively in newborns with significant hyperbilirubinemia (SH). We aimed to measure the levels of MDA, S...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2014.06.006
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2012.06.003
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abstract:BACKGROUND:The noisy component of bubble continuous positive airway pressure (CPAP) is thought to contribute to breathing efficiency and lung volume recruitment, mainly because of stochastic resonance. The magnitude and frequency of the superimposed noise are vital to this process. We wanted to evaluate the in vitro ef...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2012.08.013
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abstract:BACKGROUND:Despite advances in therapeutic modalities, congenital diaphragmatic hernia (CDH) still accounts for significant neonatal mortality. This study aimed to describe the demographic features, clinical experiences of postnatal care, and differences between non-survivors and survivors with CDH. METHODS:We retrosp...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/S1875-9572(10)60018-6
更新日期:2010-04-01 00:00:00
abstract::Methanol poisoning is rare in the pediatric population, but a delay in diagnosis and intervention may cause severe morbidity and mortality. The current therapy for methanol poisoning is ethanol or fomepizole, which acts as a competitive inhibitor of hepatic alcohol dehydrogenase to inhibit the production of toxic meta...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章,评审
doi:10.1016/j.pedneo.2013.08.009
更新日期:2016-08-01 00:00:00
abstract::The prevalence of atopic dermatitis (AD) appears to have increased dramatically over the past decades. It is generally believed that such rapid increase in prevalence cannot be explained fully by genetic factors. Environmental factors might play a role in such an increment. Children with AD are most likely to suffer c...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章,评审
doi:10.1016/j.pedneo.2015.08.005
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Currently, the pediatrician shortage in Taiwan has raised concerns about pediatricians' workloads and wellbeing. This study aimed to understand in-hospital pediatricians' perceptions toward career satisfaction and their wellbeing. METHODS:A questionnaire exploring pediatricians' life management, commitment ...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2012.11.015
更新日期:2013-06-01 00:00:00
abstract::Nystagmus is an involuntary rhythmic oscillation of the eyes, which leads to reduced visual acuity due to the excessive motion of images on the retina. Nystagmus can be grouped into infantile nystagmus (IN), which usually appears in the first 3-6 months of life, and acquired nystagmus (AN), which appears later. IN can...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章,评审
doi:10.1016/j.pedneo.2014.02.007
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Human metapneumovirus (HMPV) is a recently discovered respiratory pathogen of the family Paramyxoviridae, the same family as that of respiratory syncytial virus (RSV). Premature children are at high risk of severe RSV infections, however, it is unclear whether HMPV infection is more severe in hospitalized ch...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2015.03.008
更新日期:2016-02-01 00:00:00
abstract::Hepatic veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome, is rapidly progressing and involves life-threatening complications that can occur in patients receiving chemotherapy and/or bone marrow transplantation. No completely satisfactory treatmentstrategies have yet been established. We presen...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/S1875-9572(08)60029-7
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Hypoglycemia is common in neonates and may cause adverse neurological outcomes. Guidelines should aim to prevent repeated hypoglycemic episodes in risk groups, but they are not usually stratified according to the severity of hypoglycemia risk, which may lead to inappropriate and redundant interventions. We e...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2016.12.002
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Thrombotic microangiopathies (TMA) are microvascular occlusive disorders characterized by systemic or intrarenal platelet aggregation, thrombocytopenia, and red cell fragmentation. Post-operative TMA mostly occurs in adult patients with cardiovascular surgery, with the distinct pathophysiology from classical...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2018.02.002
更新日期:2018-12-01 00:00:00
abstract::Fetal primary cardiac tumors are rare, but they may cause complications, which are sometimes life threatening, including arrhythmias, hydrops fetalis, ventricular outflow/inflow obstruction, cardiac failure, and even sudden death. Among fetal primary cardiac tumors, rhabdomyomas are most common, followed by teratomas,...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章,评审
doi:10.1016/j.pedneo.2016.07.004
更新日期:2017-06-01 00:00:00
abstract::Multicystic dysplastic kidney (MCDK) is a congenital maldevelopment in which the renal cortex is characteristically replaced by numerous cysts of multiple sizes. MCDK presenting as a single predominant large cyst in morphology is less common. We report on the prenatal imaging findings and perinatal management of a fet...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2011.05.009
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Over the years the need for surgical treatment, timing of intervention, and the type of surgical approach have been discussed, but the treatment of congenital lung malformations remains controversial. The aim of this study was to compare the thoracotomy approach with the thoracoscopic technique by evaluating...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2015.10.009
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Pneumothorax is more frequent in the neonatal period, especially among premature infants. Pigtail catheters have been shown to be as effective as and less invasive than traditional chest tubes in adults; however, data regarding premature infants are limited. We aimed to compare the efficacy, safety, and comp...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2014.01.002
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Rankings of infant mortality rates are commonly cited international comparisons to assess the health status of individual countries. We compared the infant mortality rate of Taiwan with those of European countries for 2004 according to two definitions. METHODS:First, the countries were ranked on the basis o...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2015.07.006
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:To analyze predictive factors suggesting transient congenital hypothyroidism (TCH) compared to permanent congenital hypothyroidism (PCH) or transient thyroid function test (TFT) abnormalities among children who had positive screening results at our centers over the past decade. METHODS:A retrospective chart...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2017.01.002
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Human Rhinovirus (HRV) has been identified as the most common cause of acute respiratory infections and hospitalizations in premature children. It is unclear if premature children are more susceptible to HRV due to their decreased pulmonary reserve or because they have enhanced lower airway reactivity to HRV...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2017.04.008
更新日期:2018-06-01 00:00:00
abstract::Respiratory distress syndrome (RDS) was recognized to be caused by primary surfactant deficiency almost 70 years ago and continuous positive airway pressure was introduced approximately 50 years ago. Since then, there have been many developments in neonatology; we know many things but others are still controversial. T...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2020.11.005
更新日期:2020-12-05 00:00:00
abstract:BACKGROUND:Respiratory distress and patent ductus arteriosus (PDA) in neonates are mutually perpetuating. Contrary to the situation in premature infants, the recognition, clinical relevance and optimal management of PDA in full-term neonates are unclear. The present study aimed to identify PDA as a possible cause of re...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/S1875-9572(10)60030-7
更新日期:2010-06-01 00:00:00
abstract::Juvenile myelomonocytic leukemia (JMML) is a rare hematologic malignancy in children. Its presentations include anemia, thrombocytopenia, monocytosis, skin rash, marked hepatomegaly, and/or splenomegaly. Fever and respiratory involvement are common. Here, we report a case of a premature neonate with initial symptoms o...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2013.06.009
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Parents often express concerns about feeding difficulties in their child. We hypothesized that these parental concerns were associated with adverse growth status in early childhood. We aimed to determine the prevalence of such concerns and whether these concerns were associated with adverse growth status in ...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2019.04.004
更新日期:2019-12-01 00:00:00