Abstract:
BACKGROUND:Accumulated evidences indicate that long non-coding RNAs (lncRNAs) participate in many biological mechanisms. Moreover, it acts as an essential regulator in various human diseases such as gastric cancer (GC). Nevertheless, the comprehensive regulatory roles and clinical significance of most lncRNAs in GC are not fully understood. METHODS:In this research, our aim was to investigate the underlying mechanism of lncRNA LINC01234 in GC. Firstly, the usage of qRT-PCR helped to establish expression pattern of LINC01234 in GC tissues. Following this, appropriate statistical tests were applied to analyze the relation between expression level and clinicopathological factors. Ultimately, potential functions and regulatory network of LINC01234 were concluded via GSEA and a series of bioinformatics tools or databases, respectively. RESULTS:Consequently, at the end of research we found LINC01234 is up-regulated in GC tissues in comparison with adjacent normal tissues. Furthermore, its expression level is correlated with differentiation of patients with GC. It is also important to highlight bioinformatics analysis revealed that LINC01234 is involved in cancer-associated pathways such as cell cycle and mismatch repair. Also, regulatory network of LINC01234 presented a probability in the involvement of tumorigenesis through regulating cancer-associated genes. CONCLUSION:Overall, our results suggested that LINC01234 may play a crucial role in GC.
journal_name
J Clin Lab Analjournal_title
Journal of clinical laboratory analysisauthors
Zhu Y,Luo C,Korakkandan AA,Fatma YHA,Tao Y,Yi T,Hu S,Liao Qdoi
10.1002/jcla.23210subject
Has Abstractpub_date
2020-05-01 00:00:00pages
e23210issue
5eissn
0887-8013issn
1098-2825journal_volume
34pub_type
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