Early diagnosis of ovarian carcinoma: is a solution in sight?

Abstract:

UNLABELLED:Ovarian cancer is the most lethal of the gynecologic malignancies. Because ovarian cancer symptoms are subtle and nonspecific, the diagnosis is often delayed until the disease is well advanced. Overall 5-year survival is a rather dismal 50% but can be improved to greater than 90% if the disease is confined to the ovary at the time of diagnosis (generally in fewer than 25% of patients). Effective screening tools are currently not available. Owing to the rather low incidence of the disease in the general population, potential screening tests must provide very high specificity to avoid unnecessary interventions in false-positive cases. This article reviews currently available serum biomarkers and imaging tests for the early detection of ovarian cancer and provides an outlook on the potential improvements in these noninvasive diagnostic tools that may lead to successful implementation in a screening program. SUPPLEMENTAL MATERIAL:http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.11090563/-/DC1.

journal_name

Radiology

journal_title

Radiology

authors

Lutz AM,Willmann JK,Drescher CW,Ray P,Cochran FV,Urban N,Gambhir SS

doi

10.1148/radiol.11090563

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

329-45

issue

2

eissn

0033-8419

issn

1527-1315

pii

259/2/329

journal_volume

259

pub_type

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