Abstract:
UNLABELLED:Ovarian cancer is the most lethal of the gynecologic malignancies. Because ovarian cancer symptoms are subtle and nonspecific, the diagnosis is often delayed until the disease is well advanced. Overall 5-year survival is a rather dismal 50% but can be improved to greater than 90% if the disease is confined to the ovary at the time of diagnosis (generally in fewer than 25% of patients). Effective screening tools are currently not available. Owing to the rather low incidence of the disease in the general population, potential screening tests must provide very high specificity to avoid unnecessary interventions in false-positive cases. This article reviews currently available serum biomarkers and imaging tests for the early detection of ovarian cancer and provides an outlook on the potential improvements in these noninvasive diagnostic tools that may lead to successful implementation in a screening program. SUPPLEMENTAL MATERIAL:http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.11090563/-/DC1.
journal_name
Radiologyjournal_title
Radiologyauthors
Lutz AM,Willmann JK,Drescher CW,Ray P,Cochran FV,Urban N,Gambhir SSdoi
10.1148/radiol.11090563subject
Has Abstractpub_date
2011-05-01 00:00:00pages
329-45issue
2eissn
0033-8419issn
1527-1315pii
259/2/329journal_volume
259pub_type
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