Abstract:
:Terminal blast crisis cells of chronic granulocytic leukemia are biochemically distinct. Triton-X-114 detergent phase lysates revealed that myeloid types express predominantly proteins of a 24 kd apparent molecular weight range, whereas lymphatic types do not express these molecules but a 55 kd protein band. These biochemical differences, observed in the poorly differentiated blast crisis cells, are also found in well differentiated hemopoietic malignancies such as chronic lymphatic leukemia, or in mature granulocytes isolated from healthy individuals. The results support the concept of the different lineages of blast crisis cells in chronic granulocytic leukemia but question the role of these proteins in cell differentiation. In addition, the presence or absence of these proteins provide a helpful tool for classifying blast crises of chronic granulocytic leukemia.
journal_name
Leukemiajournal_title
Leukemiaauthors
Doxiadis I,Dölken P,Schneider M,Wernet P,Grosse-Wilde Hsubject
Has Abstractpub_date
1988-12-01 00:00:00pages
57S-62Sissue
12 Suppleissn
0887-6924issn
1476-5551journal_volume
2pub_type
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