Abstract:
:The primary goal of this study was to examine environmental and neuroendocrine factors that convey increased risk for elevated autistic behavior in boys with Fragile X syndrome (FXS). This study involves three related analyses: (1) examination of multiple dimensions of social approach behaviors and how they vary over time, (2) investigation of mean levels and modulation of salivary cortisol levels in response to social interaction, and (3) examination of the relationship of social approach and autistic behaviors to salivary cortisol. Poor social approach and elevated baseline and regulation cortisol are discernible traits that distinguish boys with FXS and ASD from boys with FXS only and from typically developing boys. In addition, blunted cortisol change is associated with increased severity of autistic behaviors only within the FXS and ASD group. Boys with FXS and ASD have distinct behavioral and neuroendocrine profiles that differentiate them from those with FXS alone and typically developing boys.
journal_name
J Neurodev Disordjournal_title
Journal of neurodevelopmental disordersauthors
Roberts JE,Clarke MA,Alcorn K,Carter JC,Long AC,Kaufmann WEdoi
10.1007/s11689-009-9028-5subject
Has Abstractpub_date
2009-12-01 00:00:00pages
283-91issue
4eissn
1866-1947issn
1866-1955journal_volume
1pub_type
杂志文章abstract:BACKGROUND:22q11.2 deletion syndrome (22q11.2DS) is the most common micro-deletion syndrome. The associated 22q11.2 deletion conveys the strongest known molecular risk for schizophrenia. Neurodevelopmental phenotypes, including intellectual disability, are also prominent though variable in severity. Other developmental...
journal_title:Journal of neurodevelopmental disorders
pub_type: 杂志文章
doi:10.1186/s11689-015-9113-x
更新日期:2015-01-01 00:00:00
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journal_title:Journal of neurodevelopmental disorders
pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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journal_title:Journal of neurodevelopmental disorders
pub_type: 杂志文章
doi:10.1186/s11689-019-9284-y
更新日期:2019-09-13 00:00:00
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journal_title:Journal of neurodevelopmental disorders
pub_type: 杂志文章
doi:10.1186/1866-1955-4-27
更新日期:2012-11-24 00:00:00
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journal_title:Journal of neurodevelopmental disorders
pub_type: 杂志文章
doi:10.1007/s11689-009-9009-8
更新日期:2009-03-01 00:00:00
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更新日期:2020-12-16 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of neurodevelopmental disorders
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Journal of neurodevelopmental disorders
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-06-07 00:00:00
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更新日期:2019-08-08 00:00:00
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journal_title:Journal of neurodevelopmental disorders
pub_type: 杂志文章
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更新日期:2019-07-10 00:00:00
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更新日期:2014-01-01 00:00:00
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journal_title:Journal of neurodevelopmental disorders
pub_type: 杂志文章
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更新日期:2017-04-05 00:00:00
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journal_title:Journal of neurodevelopmental disorders
pub_type: 杂志文章
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更新日期:2016-09-06 00:00:00
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journal_title:Journal of neurodevelopmental disorders
pub_type: 杂志文章
doi:10.1186/1866-1955-4-26
更新日期:2012-11-13 00:00:00
abstract::[This corrects the article DOI: 10.1186/s11689-016-9179-0.]. ...
journal_title:Journal of neurodevelopmental disorders
pub_type: 已发布勘误
doi:10.1186/s11689-017-9192-y
更新日期:2017-03-06 00:00:00
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pub_type: 杂志文章
doi:10.1186/s11689-018-9243-z
更新日期:2018-08-28 00:00:00
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journal_title:Journal of neurodevelopmental disorders
pub_type: 杂志文章,已发布勘误
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更新日期:2020-04-02 00:00:00
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pub_type: 杂志文章
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更新日期:2012-05-18 00:00:00
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更新日期:2019-07-31 00:00:00
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journal_title:Journal of neurodevelopmental disorders
pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
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journal_title:Journal of neurodevelopmental disorders
pub_type: 杂志文章,评审
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更新日期:2019-12-16 00:00:00
abstract:BACKGROUND:Salla disease (SD) is a rare lysosomal storage disorder leading to severe intellectual disability. SD belongs to the Finnish disease heritage, and it is caused by mutations in the SLC17A5 gene. The aim of the study was to investigate the course of neurocognitive features of SD patients in a long-term follow-...
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journal_title:Journal of neurodevelopmental disorders
pub_type: 杂志文章
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更新日期:2017-05-02 00:00:00