Pustular Psoriasis: The Dawn of a New Era.

Abstract:

:Pustular psoriasis is a clinically heterogeneous entity of different, orphan disease subtypes, among which the most clearly defined are generalized pustular psoriasis, palmoplantar psoriasis, and acrodermatitis continua of Hallopeau. Although phenotypically and genetically distinct from psoriasis vulgaris, these subtypes may be associated with plaque psoriasis lesions, establishing the rationale for their inclusion in the psoriasis spectrum. Unlike psoriasis, however, their genetic background is thought to be mainly monogenic, as shown by the recent identification of mutations in 3 different genes of the skin innate immune system; IL36RN, CARD14 and AP1S3. These major advances in the understanding of the disease pathogenesis have led to the design and ongoing development of tailored therapeutic approaches, which are highly necessary given the refractory nature of pustular psoriasis in response to most available antipsoriatic drugs.

journal_name

Acta Derm Venereol

authors

Bachelez H

doi

10.2340/00015555-3388

subject

Has Abstract

pub_date

2020-01-30 00:00:00

pages

adv00034

issue

3

eissn

0001-5555

issn

1651-2057

journal_volume

100

pub_type

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