Controlling selective stimulations below a spinal cord hemisection using brain recordings with a neural interface system approach.

Abstract:

:In this work we address the use of realtime cortical recordings for the generation of coherent, reliable and robust motor activity in spinal-lesioned animals through selective intraspinal microstimulation (ISMS). The spinal cord of adult rats was hemisectioned and groups of multielectrodes were implanted in both the central nervous system (CNS) and the spinal cord below the lesion level to establish a neural system interface (NSI). To test the reliability of this new NSI connection, highly repeatable neural responses recorded from the CNS were used as a pattern generator of an open-loop control strategy for selective ISMS of the spinal motoneurons. Our experimental procedure avoided the spontaneous non-controlled and non-repeatable neural activity that could have generated spurious ISMS and the consequent undesired muscle contractions. Combinations of complex CNS patterns generated precisely coordinated, reliable and robust motor actions.

journal_name

J Neural Eng

authors

Panetsos F,Sanchez-Jimenez A,Torets C,Largo C,Micera S

doi

10.1088/1741-2560/8/4/046008

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

046008

issue

4

eissn

1741-2560

issn

1741-2552

pii

S1741-2560(11)82339-6

journal_volume

8

pub_type

杂志文章
  • Ultraminiaturized photovoltaic and radio frequency powered optoelectronic systems for wireless optogenetics.

    abstract:OBJECTIVE:Wireless control and power harvesting systems that operate injectable, cellular-scale optoelectronic components provide important demonstrated capabilities in neuromodulatory techniques such as optogenetics. Here, we report a radio frequency (RF) control/harvesting device that offers dramatically reduced size...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/12/5/056002

    authors: Park SI,Shin G,Banks A,McCall JG,Siuda ER,Schmidt MJ,Chung HU,Noh KN,Mun JG,Rhodes J,Bruchas MR,Rogers JA

    更新日期:2015-10-01 00:00:00

  • Transparent, low-autofluorescence microECoG device for simultaneous Ca2+ imaging and cortical electrophysiology in vivo.

    abstract:OBJECTIVE:Multimodal neuroimaging approaches are beneficial to discover brain functionalities at high spatial and temporal resolution. In our work, a novel material composition of a microECoG device relying on Parylene HT and indium-tin-oxide (ITO) is presented, which facilitates two-photon imaging of Ca2+ signals and ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab603f

    authors: Zátonyi A,Madarász M,Szabó Á,Lőrincz T,Hodován R,Rózsa B,Fekete Z

    更新日期:2020-02-18 00:00:00

  • Direct activation of zebrafish neurons by ultrasonic stimulation revealed by whole CNS calcium imaging.

    abstract:OBJECTIVE:Ultrasounds (US) use in neural engineering is so far mainly limited to ablation through high intensity focused ultrasound, but interesting preliminary results show that low intensity low frequency ultrasound could be used instead to modulate neural activity. However, the extent of this modulatory ability of U...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/abae8b

    authors: Meneghetti N,Dedola F,Gavryusev V,Sancataldo G,Turrini L,de Vito G,Tiso N,Vanzi F,Carpaneto J,Cutrone A,Pavone FS,Micera S,Mazzoni A

    更新日期:2020-10-14 00:00:00

  • Towards a ternary NIRS-BCI: single-trial classification of verbal fluency task, Stroop task and unconstrained rest.

    abstract:OBJECTIVE:The majority of near-infrared spectroscopy (NIRS) brain-computer interface (BCI) studies have investigated binary classification problems. Limited work has considered differentiation of more than two mental states, or multi-class differentiation of higher-level cognitive tasks using measurements outside of th...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/12/6/066008

    authors: C Schudlo L,Chau T

    更新日期:2015-12-01 00:00:00

  • Neural correlates of speech quality dimensions analyzed using electroencephalography (EEG).

    abstract:OBJECTIVE:By means of subjective psychophysical methods, quality of transmitted speech has been decomposed into three perceptual dimensions named 'discontinuity' (F), 'noisiness' (N) and 'coloration' (C). Previous studies using electroencephalography (EEG) already reported effects of perceived intensity of single quali...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aaf122

    authors: Uhrig S,Mittag G,Möller S,Voigt-Antons JN

    更新日期:2019-06-01 00:00:00

  • Influence of proprioceptive feedback on the firing rate and recruitment of motoneurons.

    abstract::We investigated the relationships of the firing rate and maximal recruitment threshold of motoneurons recorded during isometric contraction with the number of spindles in individual muscles. At force levels above 10% of maximal voluntary contraction, the firing rate was inversely related to the number of spindles in a...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/9/1/016007

    authors: De Luca CJ,Kline JC

    更新日期:2012-02-01 00:00:00

  • An improved P300 pattern in BCI to catch user's attention.

    abstract:OBJECTIVE:Brain-computer interfaces (BCIs) can help patients who have lost control over most muscles but are still conscious and able to communicate or interact with the environment. One of the most popular types of BCI is the P300-based BCI. With this BCI, users are asked to count the number of appearances of target s...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aa6213

    authors: Jin J,Zhang H,Daly I,Wang X,Cichocki A

    更新日期:2017-06-01 00:00:00

  • Applying dynamic data collection to improve dry electrode system performance for a P300-based brain-computer interface.

    abstract:OBJECTIVE:Dry electrodes have an advantage over gel-based 'wet' electrodes by providing quicker set-up time for electroencephalography recording; however, the potentially poorer contact can result in noisier recordings. We examine the impact that this may have on brain-computer interface communication and potential app...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/13/6/066018

    authors: Clements JM,Sellers EW,Ryan DB,Caves K,Collins LM,Throckmorton CS

    更新日期:2016-12-01 00:00:00

  • DataHigh: graphical user interface for visualizing and interacting with high-dimensional neural activity.

    abstract:OBJECTIVE:Analyzing and interpreting the activity of a heterogeneous population of neurons can be challenging, especially as the number of neurons, experimental trials, and experimental conditions increases. One approach is to extract a set of latent variables that succinctly captures the prominent co-fluctuation patte...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/10/6/066012

    authors: Cowley BR,Kaufman MT,Butler ZS,Churchland MM,Ryu SI,Shenoy KV,Yu BM

    更新日期:2013-12-01 00:00:00

  • Amplitude versus spatially modulated electrotactile feedback for myoelectric control of two degrees of freedom.

    abstract:OBJECTIVE:Artificial proprioceptive feedback from a myoelectric prosthesis is an important aspect in enhancing embodiment and user satisfaction, possibly lowering the demand for visual attention while controlling a prosthesis in everyday tasks. Contemporary myoelectric prostheses are advanced mechatronic systems with m...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aba4fd

    authors: Garenfeld MA,Mortensen CK,Strbac M,Dideriksen JL,Dosen S

    更新日期:2020-08-14 00:00:00

  • Electroencephalographic (EEG) control of three-dimensional movement.

    abstract::Brain-computer interfaces (BCIs) can use brain signals from the scalp (EEG), the cortical surface (ECoG), or within the cortex to restore movement control to people who are paralyzed. Like muscle-based skills, BCIs' use requires activity-dependent adaptations in the brain that maintain stable relationships between the...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/7/3/036007

    authors: McFarland DJ,Sarnacki WA,Wolpaw JR

    更新日期:2010-06-01 00:00:00

  • A MEMS-based flexible multichannel ECoG-electrode array.

    abstract::We present a micromachined 252-channel ECoG (electrocorticogram)-electrode array, which is made of a thin polyimide foil substrate enclosing sputtered platinum electrode sites and conductor paths. The array subtends an area of approximately 35 mm by 60 mm and is designed to cover large parts of a hemisphere of a macaq...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/6/3/036003

    authors: Rubehn B,Bosman C,Oostenveld R,Fries P,Stieglitz T

    更新日期:2009-06-01 00:00:00

  • The use of tungsten as a chronically implanted material.

    abstract::This review paper shows that tungsten should not generally be used as a chronically implanted material. The metal has a long implant history, from neuroscience, vascular medicine, radiography, orthopaedics, prosthodontics, and various other fields, primarily as a result of its high density, radiopacity, tensile streng...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章,评审

    doi:10.1088/1741-2552/aaa502

    authors: Shah Idil A,Donaldson N

    更新日期:2018-04-01 00:00:00

  • Autoencoders for learning template spectrograms in electrocorticographic signals.

    abstract:OBJECTIVE:Electrocorticography (ECoG) based studies generally analyze features from specific frequency bands selected by manual evaluation of spectral power. However, the definition of these features can vary across subjects, cortical areas, tasks and across time for a given subject. We propose an autoencoder based app...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aaf13f

    authors: Pailla T,Miller KJ,Gilja V

    更新日期:2019-02-01 00:00:00

  • Ensembles of adaptive spatial filters increase BCI performance: an online evaluation.

    abstract:OBJECTIVE:In electroencephalographic (EEG) data, signals from distinct sources within the brain are widely spread by volume conduction and superimposed such that sensors receive mixtures of a multitude of signals. This reduction of spatial information strongly hampers single-trial analysis of EEG data as, for example, ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/13/4/046003

    authors: Sannelli C,Vidaurre C,Müller KR,Blankertz B

    更新日期:2016-08-01 00:00:00

  • Decoding natural reach-and-grasp actions from human EEG.

    abstract:OBJECTIVE:Despite the high number of degrees of freedom of the human hand, most actions of daily life can be executed incorporating only palmar, pincer and lateral grasp. In this study we attempt to discriminate these three different executed reach-and-grasp actions utilizing their EEG neural correlates. APPROACH:In a...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aa8911

    authors: Schwarz A,Ofner P,Pereira J,Sburlea AI,Müller-Putz GR

    更新日期:2018-02-01 00:00:00

  • Influence of nerve cuff channel count and implantation site on the separability of afferent ENG.

    abstract:OBJECTIVE:Recording of neural signals from intact peripheral nerves in patients with spinal cord injury or stroke survivors offers the possibility for the development of closed-loop sensorimotor prostheses. Nerve cuffs have been found to provide stable recordings from peripheral nerves for prolonged periods of time. Ho...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aabca0

    authors: Silveira C,Brunton E,Spendiff S,Nazarpour K

    更新日期:2018-08-01 00:00:00

  • Safety and effectiveness considerations for clinical studies of visual prosthetic devices.

    abstract::With the advent of new designs of visual prostheses for the blind, FDA is faced with developing guidance for evaluating their engineering, safety and patient performance. Visual prostheses are considered significant risk medical devices, and their use in human clinical trials must be approved by FDA under an investiga...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章,评审

    doi:10.1088/1741-2560/4/1/S14

    authors: Cohen ED

    更新日期:2007-03-01 00:00:00

  • Creation of virtual channels in the retina using synchronous and asynchronous stimulation - a modelling study.

    abstract:OBJECTIVE:Implantable retinal prostheses aim to provide artificial vision to those suffering from retinal degenerative diseases by electrically stimulating the remaining retinal neurons using a multi-electrode array. The spatial resolution of these devices can be improved by creation of so-called virtual channels (VCs)...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/abc3a9

    authors: Song X,Guo T,Shivdasani MN,Dokos S,Lovell NH,Li X,Qiu S,Li T,Zheng S,Li L

    更新日期:2020-10-21 00:00:00

  • On robust parameter estimation in brain-computer interfacing.

    abstract:OBJECTIVE:The reliable estimation of parameters such as mean or covariance matrix from noisy and high-dimensional observations is a prerequisite for successful application of signal processing and machine learning algorithms in brain-computer interfacing (BCI). This challenging task becomes significantly more difficult...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aa8232

    authors: Samek W,Nakajima S,Kawanabe M,Müller KR

    更新日期:2017-12-01 00:00:00

  • A knowledge-based approach for automatic quantification of epileptiform activity in children with electrical status epilepticus during sleep.

    abstract:OBJECTIVE:Electrical status epilepticus during sleep (ESES), as electroencephalographic disturbances, is characterized by strong activation of epileptiform activity in the electroencephalogram during sleep. Quantitative descriptors of such epileptiform activity can support the diagnose and the prognosis of children wit...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aba6dd

    authors: Zhao X,Wang X,Chen C,Fan J,Yu X,Wang Z,Akbarzadeh S,Li Q,Zhou S,Chen W

    更新日期:2020-08-11 00:00:00

  • Post-implantation impedance spectroscopy of subretinal micro-electrode arrays, OCT imaging and numerical simulation: towards a more precise neuroprosthesis monitoring tool.

    abstract:OBJECTIVE:Previous studies have shown that single-frequency impedance measurements could provide useful information about the distance between the neuroprosthesis and the retina. This work investigates the use of impedance spectroscopy in monitoring subretinal implantations of flexible micro-electrode arrays and focuse...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/10/4/046002

    authors: Pham P,Roux S,Matonti F,Dupont F,Agache V,Chavane F

    更新日期:2013-08-01 00:00:00

  • Online classification of imagined speech using functional near-infrared spectroscopy signals.

    abstract:OBJECTIVE:Most brain-computer interfaces (BCIs) based on functional near-infrared spectroscopy (fNIRS) require that users perform mental tasks such as motor imagery, mental arithmetic, or music imagery to convey a message or to answer simple yes or no questions. These cognitive tasks usually have no direct association ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aae4b9

    authors: Rezazadeh Sereshkeh A,Yousefi R,Wong AT,Chau T

    更新日期:2019-02-01 00:00:00

  • Estimates of distributed coding of visual objects by single neurons in the human brain depend on which spike sorting technique is used.

    abstract:OBJECTIVE:To determine whether the estimated fraction and degree of distribution of visual responsive neurons in human intracranial microwire recordings depends upon the spike sorting method used. APPROACH:A large dataset of human intracranial microwire recordings from four brain areas was sorted into single unit acti...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab6cb8

    authors: Steinmetz PN

    更新日期:2020-04-09 00:00:00

  • Adaptive neuron-to-EMG decoder training for FES neuroprostheses.

    abstract:OBJECTIVE:We have previously demonstrated a brain-machine interface neuroprosthetic system that provided continuous control of functional electrical stimulation (FES) and restoration of grasp in a primate model of spinal cord injury (SCI). Predicting intended EMG directly from cortical recordings provides a flexible hi...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/13/4/046009

    authors: Ethier C,Acuna D,Solla SA,Miller LE

    更新日期:2016-08-01 00:00:00

  • Effects of stimulation frequency and stimulation waveform on steady-state visual evoked potentials using a computer monitor.

    abstract:OBJECTIVE:A visual stimulator plays a vital part in brain-computer interfaces (BCIs) based on steady-state visual evoked potential (SSVEP). The properties of visual stimulation, such as frequency, color, and waveform, will influence SSVEP-based BCI performance to some extent. Recently, the computer monitor serves as a ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab2b7d

    authors: Chen X,Wang Y,Zhang S,Xu S,Gao X

    更新日期:2019-10-10 00:00:00

  • Focused electrical stimulation using a single current source.

    abstract:OBJECTIVE:Cochlear implants, while providing significant benefits to recipients, remain limited due to broad neural activation. Focussed multipolar stimulation (FMP) is an advanced stimulation strategy that uses multiple current sources to produce highly focussed patterns of neural excitation in order to overcome these...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aad0a5

    authors: Senn P,Shepherd RK,Fallon JB

    更新日期:2018-10-01 00:00:00

  • A novel training-free recognition method for SSVEP-based BCIs using dynamic window strategy.

    abstract:OBJECTIVE:Filter bank canonical correlation analysis (FBCCA) is a widely-used classification approach implemented in steady-state visual evoked potential (SSVEP)-based brain-computer interfaces (BCIs). However, conventional detection algorithms for SSVEP recognition problems, including the FBCCA, were usually based on ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab914e

    authors: Chen Y,Yang C,Chen X,Wang Y,Gao X

    更新日期:2020-05-07 00:00:00

  • In vivo two-photon microscopy reveals immediate microglial reaction to implantation of microelectrode through extension of processes.

    abstract:OBJECTIVE:Penetrating cortical neural probe technologies allow investigators to record electrical signals in the brain. Implantation of probes results in acute tissue damage, and microglia density increases around implanted devices over weeks. However, the mechanisms underlying this encapsulation are not well understoo...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/9/6/066001

    authors: Kozai TD,Vazquez AL,Weaver CL,Kim SG,Cui XT

    更新日期:2012-12-01 00:00:00

  • Pavlovian control of intraspinal microstimulation to produce over-ground walking.

    abstract:OBJECTIVE:Neuromodulation technologies are increasingly used for improving function after neural injury. To achieve a symbiotic relationship between device and user, the device must augment remaining function, and independently adapt to day-to-day changes in function. The goal of this study was to develop predictive co...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab8e8e

    authors: Dalrymple AN,Roszko DA,Sutton RS,Mushahwar VK

    更新日期:2020-06-02 00:00:00