Protein nitrotryptophan: formation, significance and identification.

Abstract:

:Reactive nitrogen species are formed during a variety of disease states and have been shown to modify several amino acids on proteins. To date, the majority of research in this area has focused on the nitration of tyrosine residues to form 3-nitrotyrosine. However, emerging evidence suggests that another modification, nitration of tryptophan residues, to form nitrotryptophan (NO(2)-Trp), may also play a significant role in the biology of nitrosative stress. This review takes an in-depth look at NO(2)-Trp, presenting the current research about its formation, prevalence and biological significance, as well as the methods used to identify NO(2)-Trp-modified proteins. Although more research is needed to understand the full biological role of NO(2)-Trp, the data presented herein suggest a contribution to nitrosative stress-induced cell dysregulation and perhaps even in physiological cell processes.

journal_name

J Proteomics

journal_title

Journal of proteomics

authors

Nuriel T,Hansler A,Gross SS

doi

10.1016/j.jprot.2011.05.032

subject

Has Abstract

pub_date

2011-10-19 00:00:00

pages

2300-12

issue

11

eissn

1874-3919

issn

1876-7737

pii

S1874-3919(11)00246-6

journal_volume

74

pub_type

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