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The effects of iron overload on mitochondrial function, mitochondrial dynamics, and ferroptosis in cardiomyocytes.

Abstract：

:Excessive iron accumulation in the heart can lead to iron overload cardiomyopathy (IOC), the leading cause of death in hemochromatosis patients. Current understanding regarding the mechanism by which iron overload causes a deterioration in cardiac performance, mitochondrial dysfunction, and impaired mitochondrial dynamics remains limited. Ferroptosis, a newly identified form of regulated cell death, has recently been revealed influencing the pathophysiological process of IOC. Nevertheless, the direct effect of cardiac iron overload on ferroptotic cell death is incompletely characterized. This review article comprehensively summarizes and discusses the effects of iron overload on cardiac mitochondrial function, cardiac mitochondrial dynamics, ferroptosis of cardiomyocytes, and left ventricular function in in vitro and in vivo reports. This review also provides relevant consistent and controversial information which can facilitate further mechanistic investigation into iron-induced cardiac dysfunction in the clinical setting in the near future.

journal_name

Arch Biochem Biophys

journal_title

Archives of biochemistry and biophysics

authors

Sumneang N,Siri-Angkul N,Kumfu S,Chattipakorn SC,Chattipakorn N

doi

10.1016/j.abb.2019.108241

subject

Has Abstract

pub_date

2020-02-15 00:00:00

pages

108241

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(19)30980-4

journal_volume

680

pub_type

杂志文章,评审

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