Corpus callosum and experimental stroke: studies in callosotomized rats and acallosal mice.

Abstract:

BACKGROUND AND PURPOSE:Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke. METHODS:We measured infarct volume and behavioral outcome after middle cerebral artery occlusion in callosotomized rats and acallosal mice. RESULTS:Neither callosotomy in rats nor callosal agenesis in mice improved infarct volume or behavioral outcome after middle cerebral artery occlusion. CONCLUSIONS:These findings argue against a role for transcallosal projections in exacerbating focal cerebral ischemia.

journal_name

Stroke

journal_title

Stroke

authors

Jin K,Xie L,Sun F,Mao X,Greenberg DA

doi

10.1161/STROKEAHA.111.613349

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

2584-8

issue

9

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.111.613349

journal_volume

42

pub_type

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