Abstract:
BACKGROUND AND PURPOSE:Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke. METHODS:We measured infarct volume and behavioral outcome after middle cerebral artery occlusion in callosotomized rats and acallosal mice. RESULTS:Neither callosotomy in rats nor callosal agenesis in mice improved infarct volume or behavioral outcome after middle cerebral artery occlusion. CONCLUSIONS:These findings argue against a role for transcallosal projections in exacerbating focal cerebral ischemia.
journal_name
Strokejournal_title
Strokeauthors
Jin K,Xie L,Sun F,Mao X,Greenberg DAdoi
10.1161/STROKEAHA.111.613349subject
Has Abstractpub_date
2011-09-01 00:00:00pages
2584-8issue
9eissn
0039-2499issn
1524-4628pii
STROKEAHA.111.613349journal_volume
42pub_type
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