Abstract:
INTRODUCTION:The association between memory loss and Hodgkin's lymphoma has been given the eponym of Ophelia syndrome, in memory of Shakespeare's character in The Tragedy of Hamlet, Prince of Denmark. Nevertheless, there are differences between the disease and the character. OBJECTIVE:To review the origins and uses of the eponym through an original article by pathologist Ian Carr, its relation to the character Ophelia, and the related autoantibodies. METHODS:Historical narrative review. RESULTS:Besides an eloquent description in the original article, Carr presaged the presence of autoantibodies, before they had been thoroughly researched. Since then, five different autoantibodies (mGluR5, Hu, NMDAR, SOX, PCA2) have been associated with Hodgkin's disease. It is interesting to note the divergent outcomes of Shakespeare's character and the patient in the original description by Carr, the latter recovering to lead a normal life, and the former deceased. CONCLUSIONS:Although there is little relationship between the fictional character and the syndrome, both imply the unintentional trigger of self-harm (suicide in one case, autoimmunity in the other), thus remaining associated.
journal_name
Arq Neuropsiquiatrjournal_title
Arquivos de neuro-psiquiatriaauthors
Soto-Rincón CA,Castillo-Torres SA,Cantú-García DA,Estrada-Bellmann I,Chávez-Luévanos B,Marfil Adoi
10.1590/0004-282X20190105subject
Has Abstractpub_date
2019-11-01 00:00:00pages
828-831issue
11eissn
0004-282Xissn
1678-4227pii
S0004-282X2019001100828journal_volume
77pub_type
传,历史文章,杂志文章abstract:OBJECTIVE:To determine frequency, etiology, site and clinical and laboratory findings of ventriculoperitoneal shunt (VPS) infections in children and adolescents with hydrocephalus managed in Hospital Governador João Alves Filho, Aracaju SE, Brazil. METHOD:A non-controlled prospective observational study comprising 50 ...
journal_title:Arquivos de neuro-psiquiatria
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doi:10.1590/s0004-282x2007000100024
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abstract::A 38 year-old man presented fever and a clinical picture of intracranial hypertension and ataxic syndrome. A CT-scan disclosed an expanding lesion of the cerebellum. Surgical excision of the lesion was performed and pathological examination made the diagnosis of an actinomycotic abscess. The probable primary source of...
journal_title:Arquivos de neuro-psiquiatria
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abstract::We conducted a 320 year retrospective survey of the history and genealogy of a large Brazilian family with SCA7. The ancestral couple was from the State of Ceará, Brazil, and the genealogical tree was composed of 577 individuals, including 217 males (37.6%), 255 females (44.1%) and 105 individuals of unknown sex (18.1...
journal_title:Arquivos de neuro-psiquiatria
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abstract::Calf enlargement following sciatica is a rare condition. It is reported the case of a 28-year-old woman who complained of repeated episodes of lower back pain radiating into the left buttock and foot. One year after the beginning of her symptoms, she noticed enlargement of her left calf. X-ray studies disclosed L5-S1 ...
journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x1992000300021
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abstract::[This corrects the article doi: 10.1590/0004-282x20180071]. ...
journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章,已发布勘误
doi:10.1590/0004-282x20180071err
更新日期:2018-12-01 00:00:00
abstract::Chédiak-Higashi syndrome is a rare hematological disease characterized by increased fusion of cytoplasmatic granules. Neurological symptoms occur in approximately half of the patients. We describe the clinical, eletrophysiological, hematological and radiological findings in a girl who had Chédiak-Higashi syndrome and ...
journal_title:Arquivos de neuro-psiquiatria
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doi:10.1590/s0004-282x1999000300024
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journal_title:Arquivos de neuro-psiquiatria
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doi:10.1590/s0004-282x2010000600014
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abstract::Since the first report addressing quantification of cerebral blood flow (CBF), concomitant assessment of cerebral oxygen consumption was also carried out. Over the years, however, some investigators have emphatically and mistakenly addressed cerebral ischemia in comatose patients, on the basis of CBF measurements alon...
journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章,评审
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journal_title:Arquivos de neuro-psiquiatria
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更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:To establish nerve conduction parameters for carpal tunnel syndrome (CTS) electrodiagnosis in the elderly. METHOD:Thirty healthy subjects (65-86 years), 9 male and 21 female, were studied. Routine median and ulnar sensory and motor nerve conduction studies, median mixed palmar latency, comparative latency te...
journal_title:Arquivos de neuro-psiquiatria
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abstract::The frequency of epilepsy in Down syndrome (DS) has been reported in literature varying from 6 to 17%. A typical electroencephalographic (EEG) pattern has not been established for this condition. There is a great variation on EEG abnormalities and most of them are not associated to behavior alterations or neurological...
journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x1999000400007
更新日期:1999-09-01 00:00:00
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journal_title:Arquivos de neuro-psiquiatria
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doi:10.1590/s0004-282x1981000200009
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x2007000700021
更新日期:2007-12-01 00:00:00
abstract::Therapeutic aspects of convulsive and non convulsive status epilepticus observed in fourteen patients with Lennox-Gastaut syndrome were studied. A temporal relationship between the status epilepticus onset and the beginning of treatment with chlonazepam and diphenylhydantoin was observed; these drugs withdrawal was fo...
journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x1977000300006
更新日期:1977-09-01 00:00:00
abstract::Normal pressure hydrocephalus (NPH) is characterized by gait disturbance, dementia and/or urinary incontinence associated with dilation of ventricular system with normal opening cerebrospinal fluid pressure. Wide scientifical evidence confirms association between NPH and psychiatric symptoms. We selected 35 patients w...
journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/0004-282x20140047
更新日期:2014-06-01 00:00:00
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x2007000400012
更新日期:2007-09-01 00:00:00
abstract::We report a case of Streptococcus pyogenes meningitis in a 18 days year-old-girl with clinical course complicated by sagittal sinus thrombosis. Some aspects of the pathogenesis, treatment and follow-up of the disease are discussed. The world increase of serious streptococcal infections in the last 10 years, probably w...
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doi:10.1590/s0004-282x2000000100022
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journal_title:Arquivos de neuro-psiquiatria
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doi:10.1590/s0004-282x1977000200011
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x1992000100021
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x1999000200018
更新日期:1999-06-01 00:00:00
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doi:
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doi:10.1590/s0004-282x2006000500030
更新日期:2006-09-01 00:00:00
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x2008000500002
更新日期:2008-09-01 00:00:00
abstract::An electrophysiological investigation of the state of the neuromuscular transmission (nmt) was carried out in 58 patients with the diagnosis of chronic Chagas' disease. On repetitive supramaximal nerve stimulation it was found that some patients did not show abnormalities, others had decremental muscle responses, othe...
journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x1989000300004
更新日期:1989-09-01 00:00:00
abstract::The myelin sheaths that surround axons in the CNS are made and maintained by oligodendrocytes. These glial cells can form variable numbers of myelin segments (internodules): from 1 to 200 so that when one oligodendrocyte is destroyed with preservation of the axon, many internodules can be lost, constituting a demyelin...
journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章,评审
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更新日期:1988-09-01 00:00:00
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x2009000300011
更新日期:2009-06-01 00:00:00
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x2009000200007
更新日期:2009-06-01 00:00:00