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Changes in spinal cord stiffness in the course of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis.

Abstract：

:Experimental autoimmune encephalomyelitis (EAE) is a commonly used mouse model of multiple sclerosis, a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination leading to brain and spinal cord malfunctions. We postulate that not only biological but also biomechanical properties play an important role in impairements of CNS function. Atomic force microscopy (AFM) was applied to investigate mechanical properties of spinal cords collected from EAE mice in preonset, onset, peak, and chronic disease phases. Biomechanical changes were compared with histopathological alterations observed in the successive phases. The deformability of gray matter did not change, while rigidity of white matter increased during the onset phase, remained at the same level in the peak phase and decreased in the chronic phase. Inflammatory infiltration and laminin content accompanied the tissue rigidity increase, whereas demyelination and axonal damage showed an opposite effect. The increase in white matter rigidity can be regarded as an early signature of EAE.

journal_name

Arch Biochem Biophys

journal_title

Archives of biochemistry and biophysics

authors

Pyka-Fościak G,Zemła J,Lis GJ,Litwin JA,Lekka M

doi

10.1016/j.abb.2019.108221

subject

Has Abstract

pub_date

2020-02-15 00:00:00

pages

108221

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(19)30705-2

journal_volume

680

pub_type

杂志文章

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