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Mechanical property characterization of electrospun recombinant human tropoelastin for vascular graft biomaterials.

Abstract：

:The development of vascular grafts has focused on finding a biomaterial that is non-thrombogenic, minimizes intimal hyperplasia, matches the mechanical properties of native vessels and allows for regeneration of arterial tissue. In this study, the structural and mechanical properties and the vascular cell compatibility of electrospun recombinant human tropoelastin (rTE) were evaluated as a potential vascular graft support matrix. Disuccinimidyl suberate (DSS) was used to cross-link electrospun rTE fibers to produce a polymeric recombinant tropoelastin (prTE) matrix that is stable in aqueous environments. Tubular 1cm diameter prTE samples were constructed for uniaxial tensile testing and 4mm small-diameter prTE tubular scaffolds were produced for burst pressure and cell compatibility evaluations from 15 wt.% rTE solutions. Uniaxial tensile tests demonstrated an average ultimate tensile strength (UTS) of 0.36±0.05 MPa and elastic moduli of 0.15±0.04 and 0.91±0.16 MPa, which were comparable to extracted native elastin. Burst pressures of 485±25 mm Hg were obtained from 4mm internal diameter scaffolds with 453±74 μm average wall thickness. prTE supported endothelial cell growth with typical endothelial cell cobblestone morphology after 48 h in culture. Cross-linked electrospun rTE has promising properties for utilization as a vascular graft biomaterial with customizable dimensions, a compliant matrix and vascular cell compatibility.

journal_name

Acta Biomater

journal_title

Acta biomaterialia

authors

McKenna KA,Hinds MT,Sarao RC,Wu PC,Maslen CL,Glanville RW,Babcock D,Gregory KW

doi

10.1016/j.actbio.2011.08.001

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

225-33

issue

1

eissn

1742-7061

issn

1878-7568

pii

S1742-7061(11)00345-X

journal_volume

8

pub_type

杂志文章

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