Inhibition of purine catabolism by benzbromarone in isolated rat liver cells. Comparison with allopurinol and probenecid.

Abstract:

:Benzbromarone, a potent uricosuric agent, inhibited allantoin production in isolated hepatocytes at concentrations half to ten times greater than therapeutic plasma levels of the drug. In addition, the drug at these concentrations also markedly inhibited xanthine oxidase (EC 1.2.1.37), an enzyme involved in the regulation of this pathway. We found that allopurinol is several times superior to benzbromarone in the lowering of allantoin production (if they are compared in terms of their relative therapeutic levels), and that probenecid had no effect on it.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Rodilla F,Sanchez-Beltran MJ,Izquierdo R,Gomez-Ruiz MD,Cabo J

doi

10.1016/0006-2952(88)90385-1

subject

Has Abstract

pub_date

1988-10-01 00:00:00

pages

3561-3

issue

19

eissn

0006-2952

issn

1873-2968

pii

0006-2952(88)90385-1

journal_volume

37

pub_type

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