Abstract:
:Pancreatic adenocarcinoma (PDAC) still represents a devastating disease associated with a very limited survival. Novel biomarkers allowing an early diagnosis as well as an optimal selection of suitable treatment options for individual patients are urgently needed to improve the dismal outcome of PDAC patients. Recently, alterations of Kisspeptin serum levels, a member of the adipokine family, were described in various types of cancers. However, the role of circulating Kisspeptin as a biomarker in PDAC patients is poorly defined. In this study, we measured Kisspeptin serum levels in a cohort of 128 prospectively enrolled PDAC patients undergoing surgical resection as well as 36 healthy controls. Kisspeptin concentrations were elevated in PDAC patients compared to control samples. Nevertheless, Kisspeptin serum levels were independent of tumor-related factors such as the tumor grading, TNM stage, or clinical features such as the ECOG performance status. Finally, in our analysis, neither preoperative nor postoperative Kisspeptin levels turned out as a significant predictor of overall survival after tumor resection. In conclusion, our data suggest that Kisspeptin concentrations are altered in PDAC patients but do not allow to predict patients' outcome after resection of PDAC.
journal_name
Dis Markersjournal_title
Disease markersauthors
Loosen SH,Luedde M,Lurje G,Spehlmann M,Paffenholz P,Ulmer TF,Tacke F,Vucur M,Trautwein C,Neumann UP,Luedde T,Roderburg Cdoi
10.1155/2019/5603474subject
Has Abstractpub_date
2019-10-20 00:00:00pages
5603474eissn
0278-0240issn
1875-8630journal_volume
2019pub_type
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