Abstract:
:Aging is a pleiotropic process affecting many aspects of mammalian physiology. Mammals are composed of distinct cell type identities and tissue environments, but the influence of these cell identities and environments on the trajectory of aging in individual cells remains unclear. Here, we performed single-cell RNA-seq on >50,000 individual cells across three tissues in young and old mice to allow for direct comparison of aging phenotypes across cell types. We found transcriptional features of aging common across many cell types, as well as features of aging unique to each type. Leveraging matrix factorization and optimal transport methods, we found that both cell identities and tissue environments exert influence on the trajectory and magnitude of aging, with cell identity influence predominating. These results suggest that aging manifests with unique directionality and magnitude across the diverse cell identities in mammals.
journal_name
Genome Resjournal_title
Genome researchauthors
Kimmel JC,Penland L,Rubinstein ND,Hendrickson DG,Kelley DR,Rosenthal AZdoi
10.1101/gr.253880.119subject
Has Abstractpub_date
2019-12-01 00:00:00pages
2088-2103issue
12eissn
1088-9051issn
1549-5469pii
gr.253880.119journal_volume
29pub_type
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