Endothelial nitric oxide synthase T(-786)C polymorphism in children and adolescents with type 1 diabetes and impaired endothelium-dependent dilatation.

Abstract:

BACKGROUND/AIMS:This study aimed to investigate the association of endothelial nitric oxide synthase (eNOS) polymorphisms with impaired endothelium-dependent dilatation (EDD) in a cohort of children and adolescents with type 1 diabetes. METHODS:Ninety-seven children and adolescents with type 1 diabetes underwent ultrasound assessment of EDD. The association of various factors with EDD was analyzed with multivariate linear regression analysis. Genotypes were determined for the eNOS T(-786)C and 4ab polymorphisms, and their association with EDD was tested with logistic regression analysis. RESULTS:Thirty-three percent of children had impaired EDD. EDD was independently associated with A1c (p = 0.0005) and inversely correlated with A1c (p = 0.0037, OR = 2.14) using logistic regression analysis. The presence of any C allele at eNOS (-786) was significantly more frequent in patients with impaired EDD (OR = 2.97, 95% CI = 1.08-8.87, p = 0.03). Logistic regression analysis revealed OR of 3.09 for impaired EDD for patients with any C allele as compared to TT patients when controlling for all other covariates (p = 0.048). CONCLUSION:A third of children and adolescents with type 1 diabetes had impaired EDD independently associated with A1c. The presence of any C at (-786) of the eNOS gene conveyed a significantly increased independent risk for impaired EDD.

journal_name

Horm Res Paediatr

authors

Battelino N,Sebestjen M,Keber I,Blagus R,Hovnik T,Bratina N,Battelino T

doi

10.1159/000329549

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

248-53

issue

4

eissn

1663-2818

issn

1663-2826

pii

000329549

journal_volume

76

pub_type

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