In vitro activity of the clinical pulmonary surfactant Surfacen® against Leishmania amazonensis.

Abstract:

:Surfacen® is an exogenous natural lung surfactant, composed by phospholipids and hydrophobic proteins, which is applied successfully in Newborn Respiratory Distress Syndrome. In this paper, in vitro activity of Surfacen® against Leishmania amazonensis is described. The product showed activity against the amastigote form found in peritoneal macrophages from BALB/c mice, with an IC50 value of 17.9 ± 3.0 µg/mL; while no toxic effect on host cell was observed up to 200 µg/mL. This is the first report about the antileishmanial activity of Surfacen®.

authors

Blanco O,Lugones Y,Díaz E,Monzote L

doi

10.1590/s0036-46652011000400012

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

235-8

issue

4

eissn

0036-4665

issn

1678-9946

pii

S0036-46652011000400012

journal_volume

53

pub_type

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