Abstract:
:Galectins constitute an evolutionary conserved family of ß-galactoside-binding proteins, ubiquitous in mammals and other vertebrate taxa, invertebrates, and fungi. Since their discovery in the 1970s, their biological roles, initially understood as limited to recognition of carbohydrate ligands in embryogenesis and development, have expanded in recent years by the discovery of their immunoregulatory activities. A gradual paradigm shift has taken place in the past few years through the recognition that galectins also bind glycans on the surface of potentially pathogenic microbes, and function as recognition and effector factors in innate immunity. Further, an additional level of functional complexity has emerged with the most recent findings that some parasites "subvert" the recognition roles of the vector/host galectins for successful attachment or invasion.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Vasta GRdoi
10.1007/978-1-4614-0106-3_2subject
Has Abstractpub_date
2012-01-01 00:00:00pages
21-36eissn
0065-2598issn
2214-8019journal_volume
946pub_type
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