Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study.

Abstract:

OBJECTIVE:To study the association between wheezy symptoms in young children and the presence of bacteria in the airways. DESIGN:Birth cohort study. SETTING:Clinical research unit in Copenhagen. PARTICIPANTS:Children of asthmatic mothers, from age 4 weeks to 3 years, with planned visits and acute admissions to the research clinic. MAIN OUTCOME MEASURE:Frequency of bacteria and virus carriage in airway aspirates during wheezy episodes and at planned visits without respiratory symptoms. RESULTS:984 samples (361 children) were analysed for bacteria, 844 (299 children) for viruses, and 696 (277 children) for both viruses and bacteria. Wheezy episodes were associated with both bacterial infection (odds ratio 2.9, 95% confidence interval 1.9 to 4.3; P<0.001) and virus infection (2.8, 1.7 to 4.4; P<0.001). The associations of bacteria and viruses were independent of each other. CONCLUSION:Acute wheezy episodes in young children were significantly associated with bacterial infections similar to but independent of the association with virus infections.

journal_name

BMJ

authors

Bisgaard H,Hermansen MN,Bønnelykke K,Stokholm J,Baty F,Skytt NL,Aniscenko J,Kebadze T,Johnston SL

doi

10.1136/bmj.c4978

subject

Has Abstract

pub_date

2010-10-04 00:00:00

pages

c4978

eissn

0959-8138

issn

1756-1833

journal_volume

341

pub_type

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