Abstract:
:Patients with aggressive adult T-cell leukemia-lymphoma (ATL) have dismal outcomes with intensive chemotherapy. Early up-front allogeneic hematopoietic stem cell transplantation (allo-HSCT) is generally recommended. However, the choice of stem cell source, i.e., unrelated bone marrow transplant (UBMT) or cord blood transplantation (CBT), when an HLA-matched related donor is unavailable remains controversial. Thus, we undertook a decision analysis to compare the outcomes of two therapeutic strategies: chemotherapy followed by up-front UBMT at 6 months, and chemotherapy followed by up-front CBT at 3 months. Patients were stratified into low-, intermediate-, and high-risk groups according to the modified ATL-prognostic index. The model simulated life expectancy (LE) and quality-adjusted LE (QALE). LE following up-front UBMT was higher than that following up-front CBT in the low-risk group (2.63 vs. 2.28 years), but was comparable in the intermediate- (2.06 vs. 2.01 years) and high-risk groups (1.25 vs. 1.30 years). The Monte Carlo simulation for LE and QALE in each risk group showed that there was significant uncertainty in all categories. In conclusion, up-front UBMT was superior to up-front CBT in the low-risk group, but the strategies were comparable in the intermediate- and high-risk groups.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Fuji S,Kurosawa S,Inamoto Y,Murata T,Utsunomiya A,Uchimaru K,Yamasaki S,Inoue Y,Moriuchi Y,Choi I,Ogata M,Hidaka M,Yamaguchi T,Fukuda Tdoi
10.1007/s12185-019-02777-wsubject
Has Abstractpub_date
2020-03-01 00:00:00pages
427-433issue
3eissn
0925-5710issn
1865-3774pii
10.1007/s12185-019-02777-wjournal_volume
111pub_type
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journal_title:International journal of hematology
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