Abstract:
BACKGROUND:The aim of this study was to determine the prevalence of human papillomavirus (HPV) and 15 species that cause sexually transmitted infections (STIs) in negative cytology. In addition, we compared the diagnostic performance of multiplex polymerase chain reaction (PCR) with widely available techniques used to detect HPV. METHODS:We recruited 235 women of reproductive age who had negative cytology findings in a liquid-based cervical smear. STIs were identified by multiplex PCR, and HPV genotypes by multiplex PCR, hybrid capture 2, and DNA microaray; discordant results were analyzed by direct sequencing. RESULTS:Approximately 96.6% of patients with negative cytology results were positive for pathogens that cause STIs. The pathogens most frequently detected were Gardnerella vaginalis, Ureaplasma urealyticum. The incidence of HPV in negative cytology was 23.3%. Low-risk HPV infection was significantly correlated with Chalmaydia trachomatis, and high-risk HPV infection was significantly correlated with Group β streptococcus. The analytical sensitivities of the multiplex PCR and DNA microarray were higher than 80%, and the analytical specificity was nearly 100% for all tests. CONCLUSIONS:Multiplex PCR yielded results that most of patients with negative cytology were positive for pathogens that cause STIs, and were more similar to that of DNA microarray, than that of hybrid capture 2 in terms of analytical sensitivity and prediction value of HPV infection.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Shim HS,Noh S,Park AR,Lee YN,Kim JK,Chung HJ,Kang KS,Cho NHdoi
10.1186/1471-2334-10-284subject
Has Abstractpub_date
2010-09-28 00:00:00pages
284issn
1471-2334pii
1471-2334-10-284journal_volume
10pub_type
杂志文章abstract:BACKGROUND:Data regarding HIV-seronegative pediatric patients with cryptococcal meningitis (CM) have been very limited. METHODS:We retrospectively reviewed non-HIV-infected in patients with CM from January 2002 through December 2013 in Beijing Children's Hospital. Records of the all patients were obtained and compared...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1964-6
更新日期:2016-11-04 00:00:00
abstract:BACKGROUND:The presence of diabetes mellitus increases the risk of several severe infections, but data on its effect on treatment outcomes in patients with nosocomial pneumonia (NP) caused by methicillin-resistant Staphylococcus aureus (MRSA) are limited. METHODS:We retrospectively analyzed data from a double-blind, r...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12879-016-1779-5
更新日期:2016-09-06 00:00:00
abstract:BACKGROUND:Fusobacterium species (spp.) bacteremia is uncommon and has been associated with a variety of clinical presentations. We conducted a retrospective, population based study to determine the relative proportion of species in this genus causing bacteremia and the risk factors for infection and adverse clinical o...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-264
更新日期:2013-06-05 00:00:00
abstract:BACKGROUND:Malnutrition and malaria frequently coexist in sub-Saharan African countries. Studies on efficacy of antimalarial treatments usually follow the WHO standardized protocol in which severely malnourished children are systematically excluded. Few studies have assessed the efficacy of chloroquine, sulfadoxine-pyr...
journal_title:BMC infectious diseases
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/s12879-015-0963-3
更新日期:2015-06-12 00:00:00
abstract:BACKGROUND:Following delivery by caesarean section, surgical site infection is the most common infectious complication. Despite a large number of caesarean sections performed at Debre Markos Referral Hospital, there was no study documenting the incidence of surgical site infection after caesarean section. Therefore, th...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05640-0
更新日期:2020-11-30 00:00:00
abstract:BACKGROUND:Erythema induratum of Bazin (EIB) - nodular vasculitis associated with Mycobacterium tuberculosis (TB) - and Tuberculosis-Associated Ocular Inflammation (TB-AOI) represent uncommon manifestations of TB. There is limited data and a lack of diagnostic and treatment standards for these conditions. METHODS:Elev...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3737-5
更新日期:2019-01-29 00:00:00
abstract:BACKGROUND:No comparison data have been reported on viral and epidemiological profiles of hospitalized children with severe acute respiratory infection (SARI) in Beijing or Shanghai, China. METHODS:We collected 700 nasopharyngeal aspirates (NPA) from hospitalized children with SARI in Beijing (northern China) and Shan...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4385-5
更新日期:2019-08-20 00:00:00
abstract:BACKGROUND:In patients with chronic respiratory disease, Pneumocystis jirovecii (P. jirovecii) colonization is observed, and may influence disease progression and systemic inflammation. Pneumocystis pneumonia causes interstitial changes, so making a diagnosis of PCP in patients who have interstitial pneumonia (IP) with...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-9-47
更新日期:2009-04-22 00:00:00
abstract:BACKGROUND:Hospital-based surveillance for pneumococcal meningitis has been conducted since January 1996 in the city of Salvador, Brazil. The purpose of this study was to describe the temporal evolution of Penicillin Non-Susceptible Streptococcus pneumoniae (PNSSP) in regards to serotype distributions and clonal divers...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1049-y
更新日期:2015-07-30 00:00:00
abstract:BACKGROUND:Mutations in the basic core promoter (BCP) and its adjacent precore (preC) region in HBV genome are common in chronic hepatitis B patients. However, the patterns of mutation combinations in these two regions during chronic infection are less understood. This study focused on single base mutations in BCP and ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-271
更新日期:2010-09-16 00:00:00
abstract:INTRODUCTION:Late presentation to HIV/AIDS care which is attended by problems like, poor treatment outcomes, early development of opportunistic infections, increased healthcare costs, and mortality is a major problem in Ethiopia. Although evidences are available on the prevalence and associated factors of late presenta...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析
doi:10.1186/s12879-019-4156-3
更新日期:2019-06-17 00:00:00
abstract:BACKGROUND:Antiretroviral therapy (ART) agents potentially associated with adverse metabolic profiles are commonly used in low- and middle-income countries. We assessed risk factors for cardiovascular disease (CVD)-related morbidity and mortality in a cohort of HIV-infected, ART-treated adults in Rio de Janeiro, Brazil...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1735-4
更新日期:2016-08-08 00:00:00
abstract:BACKGROUND:Central nervous system (CNS) infections are a significant contributor to morbidity and mortality globally. However, most published studies have been conducted in developed countries where the epidemiology and aetiology differ significantly from less developed areas. Additionally, there may be regional differ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1640-x
更新日期:2016-06-16 00:00:00
abstract:BACKGROUND:In Australia two acellular Bordetella pertussis vaccines have replaced the use of a whole cell vaccine. Both of the licensed acellular vaccines contain the following three components; pertussis toxoid, pertussis filamentous haemagglutinin and the 69 kDa pertactin adhesin. One vaccine also contains pertussis ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-6-53
更新日期:2006-03-16 00:00:00
abstract:BACKGROUND:The risk of life-threatening complications, such as visceral disseminated varicella zoster virus (VZV) infection, is greater in immunosuppressed individuals, such as systemic lupus erythematosus (SLE) patients. CASE PRESENTATION:Here, a case is reported of a Caucasian woman diagnosed with lupus nephritis an...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05254-6
更新日期:2020-07-23 00:00:00
abstract:BACKGROUND:The steady rise in the spread of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) requires rapid and reliable methods to identify resistant strains. The current molecular methods to detect MTB resistance to second-line drugs either do not cover an extended spectr...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-240
更新日期:2013-05-24 00:00:00
abstract:BACKGROUND:The objective of this study was to explore effects of khat (Catha edulis) on outcome of rodent malaria infection and its anti-plasmodial activities on Plasmodium berghei ANKA (PbA). METHODS:Female Swiss albino mice were orally treated with crude khat (Catha edulis) extracts (100, 200 and 300 mg/kg) on a dai...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0911-2
更新日期:2015-04-02 00:00:00
abstract:BACKGROUND:The association of Chlamydia pneumoniae with atherosclerosis is controversial. We investigated the presence of C. pneumoniae and other Chlamydia spp. in atheromatous carotid artery tissue. METHODS:Forty elective carotid endarterectomy patients were recruited (27 males, mean age 65 and 13 females mean age 68...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-1-12
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Giardia duodenalis is a flagellate parasite which has been considered the most common protozoa infecting human worldwide. Molecular characterization of G. duodenalis isolates have revealed the existence of eight groups (Assemblage A to H) which differ in their host distribution. Assemblages A and B are found...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-78
更新日期:2014-02-12 00:00:00
abstract:BACKGROUND:After the onset of HAART, some HIV-infected individuals under treatment present a exacerbated inflammation in response to a latent or a previously treated opportunistic pathogen termed immune reconstitution inflammatory syndrome (IRIS). Few reports of tegumentary leishmaniasis have been described in associat...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0774-6
更新日期:2015-02-03 00:00:00
abstract:BACKGROUND:Rapid diagnostic tests (RDTs) are alternative methods for microscopy in the diagnosis of malaria in resource limited settings. Among commercially available RDTs, CareStart™ Malaria test was found to show reliable results. This study evaluated the performance of CareStart™ Malaria Combo test kit in Northweste...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2503-9
更新日期:2017-06-06 00:00:00
abstract:BACKGROUND:The swine influenza H1N1 first identified in Mexico, spread rapidly across the globe and is considered the fastest moving pandemic in history. The early phase of an outbreak, in which data is relatively scarce, presents scientific challenges on key issues such as: scale, severity and immunity which are funda...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-92
更新日期:2011-04-14 00:00:00
abstract:BACKGROUND:Human papillomavirus (HPV) is one of the most common sexually-transmitted pathogens. A number of studies in the literature have estimated the burden of HPV-related diseases by collecting data at primary care level, while a comprehensive assessment of the global burden of HPV-related diseases on hospital reso...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-462
更新日期:2013-10-05 00:00:00
abstract:BACKGROUND:The incidence of tuberculous pericarditis has increased in Africa as a result of the human immunodeficiency virus (HIV) epidemic. However, the effect of HIV co-infection on clinical features and prognosis in tuberculous pericarditis is not well characterised. We have used baseline data of the Investigation o...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2334-6-2
更新日期:2006-01-06 00:00:00
abstract:BACKGROUND:Pertussis causes severe disease in young unvaccinated infants, with preterms potentially at highest risk. We studied pertussis in hospitalized infants as related to gestational age (GA) and vaccination history. METHODS:Medical record data of 0-2y old patients hospitalized for pertussis during 2005-2014 were...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4563-5
更新日期:2019-10-29 00:00:00
abstract:BACKGROUND:Granulomas caused by Mycobacterium Tuberculosis have been observed at autopsy in the heart, pre-dominantly in the myocardium and endocardium, but rarely involving the coronary vessels and valvular structures. Mycobacterium tuberculosis valvular endocarditis is extremely rare, with most reports coming from au...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-231
更新日期:2012-09-27 00:00:00
abstract:BACKGROUND:Contact tracing of tuberculosis (TB) patients is rarely performed in low-income countries. Our objective was to assess the outcome of and compliance with directly observed treatment (DOTS) of TB patients over a 3 year period in rural Lao PDR. METHODS:We performed a retrospective cohort study in which we enr...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-265
更新日期:2010-09-10 00:00:00
abstract:BACKGROUND:Penicillium marneffei disseminates hematogenously and can infect most organs, though infection leading to osteolysis is extremely rare. We describe the clinical and laboratory features, management, and outcomes of patients with penicilliosis marneffei (PSM) with osteolytic lesions. METHODS:This retrospectiv...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0782-6
更新日期:2015-02-06 00:00:00
abstract:BACKGROUND:Acinetobacter species are associated with increasing mortality due to emerging drug-resistance. Pediatric Acinetobacter infections are largely undefined in developed countries and clinical laboratory identification methods do not reliably differentiate between members of the Acinetobacter calcoaceticus-bauma...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1678-9
更新日期:2016-07-22 00:00:00
abstract:BACKGROUND:To determine the association of human papillomavirus infection (HPV) and transitional cell carcinoma (TCC). METHODS:Using polymerase chain reaction, fifty-nine bladder tissue specimens of patients with transitional cell carcinoma of bladder compared with 20 bladder samples of cases with non-neoplastic disor...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-5-102
更新日期:2005-11-08 00:00:00