Abstract:
PURPOSE:This study aimed to examine whether long-term fish oil (FO) supplementation is associated with a lower risk of mobility disability and enhances benefits of physical activity (PA). METHODS:A total of 1635 sedentary adults age 70 to 89 yr from the Lifestyle Interventions and Independence for Elders single-blinded randomized, multicenter clinical trial, which compared a structured PA program to a health education program. Primary outcome was incident major mobility disability (MMD), defined by loss of ability to walk 400 m, measured every 6 months for an average of 2.6 yr. Secondary outcomes included persistent mobility disability, Short Physical Performance Battery, 400-m walk speed, and grip strength. RESULTS:A third of participants reported using FO at baseline (456 (28%); mean age, 78.5 yr; 70.5% women). MMD was experienced by 131 participants (28.7%) in the FO group and 405 (34.4%) participants in the nonuser group. After adjusting for confounders, FO supplementation was associated with a lower risk (HR, 0.78; 95% confidence interval (CI), 0.64-0.96) of incident MMD. However, there was no interaction (P = 0.19) between FO supplementation and PA intervention for MMD. For the secondary outcome of persistent mobility disability, the intervention association differed by supplementation (P = 0.002) with PA intervention associations of (HR, 1.36; 95% CI, 0.83-2.23) for users and (HR, 0.61; 95% CI, 0.46-0.81) for nonusers. Changes in physical performance outcomes were not modified by baseline FO supplementation or combination with PA. CONCLUSIONS:FO supplementation was associated with a lower risk of MMD in low to moderate functioning older adults. However, supplementation did not enhance the benefit of PA on risk of mobility disability. These results are hypothesis generating and need to be confirmed in randomized trials.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Balachandran A,Gundermann DM,Walkup MP,King AC,Ambrosius WT,Kritchevsky SB,Pahor M,Newman AB,Manini TMdoi
10.1249/MSS.0000000000002195subject
Has Abstractpub_date
2020-04-01 00:00:00pages
859-867issue
4eissn
0195-9131issn
1530-0315journal_volume
52pub_type
杂志文章,多中心研究,随机对照试验abstract:PURPOSE:One approach to studying the effects of aging on physiological functional capacity (PFC) in humans is to analyze the peak physical performance of trained athletes with increasing age. The primary aim of the present study was to determine weightlifting and powerlifting performance with increasing age in both men...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.MSS.0000106283.34742.BE
更新日期:2004-01-01 00:00:00
abstract::Although no conclusive evidence exists to suggest that vitamin supplementation improves athletic performance in nutritionally adequate individuals, exercise may increase requirements for certain vitamins in individuals with marginal vitamin stores. This review summarizes results from recent research studies of vitamin...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1987-10-01 00:00:00
abstract:PURPOSE:This study evaluated the factorial validity of a self-report measure of concussion-related symptom severity among a large sample of male, high-school athletes. METHODS:Participants (N = 1089) were nonconcussed, male, high-school football players. All participants completed a single baseline self-report measure...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000183186.98212.d5
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:This study was conducted to determine the effect of high pedaling cadences on maximal cycling power output (W(max)). METHODS:Nine well-trained cyclists performed a continuous, incremental cycle-ergometer test to exhaustion (25 W increases every 3 min) either at 80, 100, or 120 rpm on three different occasions....
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000218139.46166.ec
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abstract:PURPOSE:To examine the relationship of physical activity and its changes over a 9-yr follow-up to the prevalence of metabolic syndrome (MetS) in 2060 young adults (24-39 yr) enrolled in the Cardiovascular Risk in Young Finns Study. METHODS:Leisure-time physical activity (LTPA) was assessed using a self-report question...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e318172ced4
更新日期:2008-08-01 00:00:00
abstract::Influence of post-surgery time after cardiac transplantation on exercise responses. Med. Sci. Sports Exerc., Vol. 28, No. 2, pp. 171-175, 1996. To test the hypothesis that exercise response changes with time after cardiac transplantation, we investigated the cardiorespiratory responses of nine orthotopic heart transpl...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1097/00005768-199602000-00003
更新日期:1996-02-01 00:00:00
abstract::The purpose of this study was to determine the feasibility of using a 6" digital caliper and a 20x viewing microscope to measure hematocrit (HCT) from microhematocrit tubes. The reliability and validity of the digital caliper technique (DC) was simultaneously compared with that of the conventional "turntable" style mi...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract:PURPOSE:Previous studies have suggested that extreme endurance exercise may induce cardiac microdamage that could lead to subsequent myocardial fibrosis. Soluble suppression of tumorigenicity 2 (sST2) is a cardiac biomarker for assessment of myocardial fibrosis, inflammation, and strain. We evaluated baseline and exerc...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001806
更新日期:2019-03-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 共识发展会议,杂志文章
doi:10.1249/MSS.0b013e31818acdcb
更新日期:2008-11-01 00:00:00
abstract::In a cross-sectional study using a two-stage probability sample (N = 1,600) of the population of Northern Ireland, there was an inverse association between the highest recorded recent activity and total cholesterol (P < or = 0.01), LDL (P < or = 0.01), triglyceride (P < or = 0.05) and Chol:HDL ratio (P < or = 0.001) i...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199606000-00011
更新日期:1996-06-01 00:00:00
abstract::This study examined the association between aerobic, caloric exercise expenditure and life status (living vs deceased) as well as the prevalence rates of hypertension (HBP) and cardiovascular disease (CVD) in former male athletes (ATH) and non-athletes (N-ATH). The initial survey for this study was done in 1952. Follo...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-199012000-00002
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND:Recently, triaxial raw acceleration accelerometers have become available from GENEActiv and ActiGraph; both are designed for wrist and hip wear. It is important to determine whether the output from these monitors is comparable with the wealth of data already collected from the hip-worn, epoch-based, uniaxial...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000365
更新日期:2014-12-01 00:00:00
abstract:INTRODUCTION:Competitive female athletes restrict energy intake and increase exercise energy expenditure frequently resulting in ovarian suppression. The purpose of this study was to determine the impact of ovarian suppression and energy deficit on swimming performance (400-m swim velocity). METHODS:Menstrual status w...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3182a32b72
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:Cigarette smoking is the main risk factor for chronic obstructive pulmonary disease and emphysema. However, evidence on the extrapulmonary effects of smoke exposure that precede lung impairments remains unclear at present, as are data on nonpharmacological treatments such as exercise training. METHODS:Three gr...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001195
更新日期:2017-05-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181d85527
更新日期:2010-09-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000436
更新日期:2015-03-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1097/00005768-200009000-00021
更新日期:2000-09-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1097/00005768-200206000-00007
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181cd5cb9
更新日期:2010-07-01 00:00:00
abstract:INTRODUCTION:The significant sex disparity in sports-related knee injuries may be due to underlying differences in motor control. Although the development of sex-specific movement patterns is likely multifactorial, this study specifically focuses on the potential modulatory role of sex hormones. PURPOSE:This study aim...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000134
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journal_title:Medicine and science in sports and exercise
pub_type:
doi:10.1249/MSS.0b013e3181ce9f85
更新日期:2010-03-01 00:00:00
abstract::Twelve male swimmers were studied psychologically before, during, and after 10 d of increased training. Daily training distance was increased from 4,000 to 9,000 m.d-1, and intensity was maintained at 94% of VO2max. Three of the swimmers were unable to tolerate the increased training load, and they did the same distan...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-198808000-00014
更新日期:1988-08-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
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更新日期:2003-06-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181c29e90
更新日期:2010-05-01 00:00:00
abstract::Sprint-trained athletes demonstrate a remarkable ability to perform exercise which results in fatigue quickly. However, the mechanisms for these enhanced performance capabilities have not been fully elucidated. Elevation in glycolytic enzymes and increased fast-twitch fiber compositions which would result in an enhanc...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:
更新日期:1984-08-01 00:00:00
abstract:PURPOSE:The purpose of the present study was to examine the effect of muscle activity level on serum creatine kinase (CK) activity after high-force eccentric exercise of the elbow flexors. METHODS:Twenty-six male volunteers were randomly assigned to one of three groups for a 4-d treatment period after exercise: immobi...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
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更新日期:2000-09-01 00:00:00
abstract:PURPOSE:The objective of this study is to test the feasibility and impact of a 10-wk after-school exercise program for children with attention deficit hyperactivity disorder and/or disruptive behavior disorders living in an urban poor community. METHODS:Children were randomized to an exercise program (n = 19) or a com...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
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更新日期:2016-07-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000142403.93205.35
更新日期:2004-10-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
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更新日期:2020-11-03 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200010000-00006
更新日期:2000-10-01 00:00:00