Characterization of CIA-1, an Ambler class A extended-spectrum β-lactamase from Chryseobacterium indologenes.

abstract：:Loss of viability of toxin-treated cells of Saccharomyces cerevisiae SCF 1717 could be prevented in the period before they altered physiologically if cells were incubated in media with a suitable concentration of potassium (0.08 to 0.13 M) and hydrogen ions (pH 6.2 to 6.7). Incorporation of higher amounts of potassium...

journal_title：Antimicrobial agents and chemotherapy

authors： Middelbeek EJ,Crützen QH,Vogels GD

更新日期：1980-10-01 00:00:00

abstract：:We studied the efficacy of new experimental antifungal drugs, which represent molecular modifications of present active agents, in a murine model of blastomycosis. Ketoconazole, previously the best azole drug studied and which is protective when administered orally, was superior to a new oral imidazole, Bay l 9139, an...

journal_title：Antimicrobial agents and chemotherapy

authors： Lefler E,Brummer E,Perlman AM,Stevens DA

更新日期：1985-03-01 00:00:00

abstract：:A sensitive, precise microbiological assay was developed for the determination of tissue distribution of dl-alanosine, a new antitumor agent. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pittillo RF,Woolley C

更新日期：1973-06-01 00:00:00

abstract：:Ceftizoxime, a new cephalosporin, was active against Pseudomonas cepacia, Flavobacterium meningosepticum, Alcaligenes faecalis, and Acinetobacter calcoaceticus and was more potent against Pseudomonas aeruginosa and Pseudomonas putida than was carbenicillin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yabuuchi E,Ito T,Tanimura E,Yamamoto N,Ohyama A

更新日期：1981-07-01 00:00:00

abstract：:Levofloxacin is increasingly used in the treatment of multidrug-resistant tuberculosis (MDR-TB). There are limited pediatric pharmacokinetic data to inform dose selection for children. Children routinely receiving levofloxacin (250-mg adult tablets) for MDR-TB prophylaxis or disease in Cape Town, South Africa, underwe...

journal_title：Antimicrobial agents and chemotherapy

authors： Denti P,Garcia-Prats AJ,Draper HR,Wiesner L,Winckler J,Thee S,Dooley KE,Savic RM,McIlleron HM,Schaaf HS,Hesseling AC

更新日期：2018-01-25 00:00:00

abstract：:Cefmenoxime, an investigational semisynthetic cephalosporin, was evaluated in 18 pediatric patients with a variety of infections. There were seven patients with urinary tract infections, two with wound infections, two with osteomyelitis, two with abscess infections, one with cervical adenitis, one with hidradenitis, o...

journal_title：Antimicrobial agents and chemotherapy

authors： Tansino GF,Hammerschlag MR,Congeni BL,Cox PA,Doraiswamy B,duBouchet L

更新日期：1985-10-01 00:00:00

abstract：:The high levels of hepatitis B virus (HBV) surface antigen (HBsAg)-bearing subviral particles in the serum of chronically infected individuals are thought to play a role in suppressing the HBV-specific immune response. Current therapeutics are not directed at reducing this viral antigenemia; thus, our group has focuse...

journal_title：Antimicrobial agents and chemotherapy

authors： Dougherty AM,Guo H,Westby G,Liu Y,Simsek E,Guo JT,Mehta A,Norton P,Gu B,Block T,Cuconati A

更新日期：2007-12-01 00:00:00

abstract：:Biofilms are complex communities of microorganisms that attach to surfaces and are embedded in a self-produced extracellular matrix. Since these cells acquire increased tolerance against antimicrobial agents and host immune systems, biofilm-associated infectious diseases tend to become chronic. We show here that the m...

journal_title：Antimicrobial agents and chemotherapy

authors： Arita-Morioka K,Yamanaka K,Mizunoe Y,Ogura T,Sugimoto S

更新日期：2015-01-01 00:00:00

abstract：:The opportunistic Gram-negative pathogen Pseudomonas aeruginosa, known for its intrinsic and acquired antibiotic resistance, has a notorious ability to form biofilms, which often facilitate chronic infections. The evolutionary paths to antibiotic resistance have mainly been investigated in planktonic cultures and are ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahmed MN,Porse A,Sommer MOA,Høiby N,Ciofu O

更新日期：2018-07-27 00:00:00

abstract：:We present a 31-year-old female who had undergone an allogeneic bone marrow transplantation and who was started on intravenous posaconazole for pulmonary mycosis while undergoing continuous venovenous hemofiltration (CVVH). We performed steady-state pharmacokinetic evaluations for both posaconazole and sulfobutylether...

journal_title：Antimicrobial agents and chemotherapy

authors： Morris AA,Mueller SW,Rower JE,Washburn T,Kiser TH

更新日期：2015-10-01 00:00:00

abstract：:The determination of antibiotic potency against bacterial strains by assessment of their minimum inhibitory concentration normally uses a standardized broth microdilution assay procedure developed more than 50 years ago. However, certain antibiotics require modified assay conditions in order to observe optimal activit...

journal_title：Antimicrobial agents and chemotherapy

authors： Kavanagh A,Ramu S,Gong Y,Cooper MA,Blaskovich MAT

更新日期：2018-12-21 00:00:00

abstract：:MICs of daptomycin, linezolid, and vancomycin against 212 isolates, including Listeria monocytogenes and Pediococcus, Leuconostoc, Rhodococcus, and Nocardia spp., were determined by the broth microdilution method; daptomycin MICs were also determined by the Etest. Except with those for Leuconostoc spp., daptomycin Ete...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang YT,Liao CH,Teng LJ,Hsueh PR

更新日期：2007-04-01 00:00:00

abstract：:We have analyzed the contribution of different efflux components to glutathione-mediated abrogation of ciprofloxacin's activity in Escherichia coli and the underlying potential mechanism(s) behind this phenomenon. The results indicated that glutathione increased the total active efflux, thereby partially contributing ...

journal_title：Antimicrobial agents and chemotherapy

authors： Goswami M,Subramanian M,Kumar R,Jass J,Jawali N

更新日期：2016-06-20 00:00:00

abstract：:In a hospital-based, prospective cohort study, the effects of the three standard treatment regimens for mild Clostridium difficile infection (CDI), oral (p.o.) metronidazole at 500 mg three times/day, intravenous (i.v.) metronidazole at 500 mg three times/day, and oral (p.o.) vancomycin at 250 mg four times/day, were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wenisch JM,Schmid D,Kuo HW,Allerberger F,Michl V,Tesik P,Tucek G,Laferl H,Wenisch C

更新日期：2012-04-01 00:00:00

abstract：:The interaction of miltefosine with amphotericin B, sodium stibogluconate, paromomycin, and sitamaquine was assessed in vitro and additionally for the first three combinations in vivo. In vitro interactions were indifferent for miltefosine combined with amphotericin B (mean sums of fractional inhibitory concentrations...

journal_title：Antimicrobial agents and chemotherapy

authors： Seifert K,Croft SL

更新日期：2006-01-01 00:00:00

abstract：:Using a rabbit model of methicillin-resistant Staphylococcus aureus knee-prosthesis infection, we studied the efficacy of teicoplanin cement alone or in combination with systemic intramuscular (i.m.) injections of teicoplanin. Seven days after infection, surgical debridement and removal of the infected prostheses were...

journal_title：Antimicrobial agents and chemotherapy

authors： Ismael F,Bléton R,Saleh-Mghir A,Dautrey S,Massias L,Crémieux AC

更新日期：2003-10-01 00:00:00

abstract：:Control of membrane permeability is a key step in regulating the intracellular concentration of antibiotics. Efflux pumps confer innate resistance to a wide range of toxic compounds such as antibiotics, dyes, detergents, and disinfectants in members of the Enterobacteriaceae. The AcrAB-TolC efflux pump is involved in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pérez A,Poza M,Aranda J,Latasa C,Medrano FJ,Tomás M,Romero A,Lasa I,Bou G

更新日期：2012-12-01 00:00:00

abstract：:A novel trait for transferable resistance to high concentrations of trimethoprim was found to dominate among enterobacteria collected from different parts of Sri Lanka. Drug resistance was a result of the production of dihydrofolate reductase with a decreased sensitivity to antifolates. By characterization of the part...

journal_title：Antimicrobial agents and chemotherapy

authors： Sundström L,Vinayagamoorthy T,Sköld O

更新日期：1987-01-01 00:00:00

abstract：:While the inflammatory response to severe pneumonia is paramount in limiting and resolving the infection, excessive inflammation can lead to deleterious effects. We theorized that patients with severe community-acquired pneumonia (CAP) who were treated with macrolides and aspirin would receive benefit beyond that of c...

journal_title：Antimicrobial agents and chemotherapy

authors： Falcone M,Russo A,Shindo Y,Farcomeni A,Pieralli F,Cangemi R,Liu J,Xia J,Okumura J,Sano M,Jones C,Vannucchi V,Mancone M,Micek S,Xu F,Violi F,Kollef M

更新日期：2019-01-29 00:00:00

abstract：:The metabolic fate of the orally effective cephalosporin antibiotic cefaclor (Lilly 99638) has been studied in rats, mice, and dogs. Cefaclor is efficiently absorbed from the gastrointestinal tract as the intact antibiotic. In rats and mice, cefaclor, for the most part, escapes metabolism in the body and is eliminated...

journal_title：Antimicrobial agents and chemotherapy

authors： Sullivan HR,Due SL,Kau DL,Quay JF,Miller W

更新日期：1976-10-01 00:00:00

abstract：:The use of dialysis fermentation with the continuous extraction of the dialysate has resulted in a twofold increase in the cycloheximide titer due to relief from product inhibition. Continuous extraction of the dialysate has eliminated the necessity for large reservoir volumes of fermentation medium normally used in d...

journal_title：Antimicrobial agents and chemotherapy

authors： Kominek LA

更新日期：1975-06-01 00:00:00

abstract：:We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic....

journal_title：Antimicrobial agents and chemotherapy

authors： Sutherland CJ,Lansdell P,Sanders M,Muwanguzi J,van Schalkwyk DA,Kaur H,Nolder D,Tucker J,Bennett HM,Otto TD,Berriman M,Patel TA,Lynn R,Gkrania-Klotsas E,Chiodini PL

更新日期：2017-02-23 00:00:00

abstract：:A number of proflavine (PF)-resistant mutants of Escherichia coli B were also resistant to penicillin and cephalothin. Mutants resistant to 1.0 mM PF were 10 times more penicillin resistant than were the PF-susceptible, wild-type cells. Single-step mutants selected for resistance to either PF or penicillin were also r...

journal_title：Antimicrobial agents and chemotherapy

authors： McKellar RC,McKenzie CN,Kushner KJ

更新日期：1976-10-01 00:00:00

abstract：:Piperacillin and vancomycin were used as initial empirical therapy for 211 febrile episodes in cancer patients. The response rate in 95 episodes of documented infection was 72%. The response of bacteremias, soft tissue infections, and pneumonias was 78, 71, and 38%, respectively. The response in infections caused by g...

journal_title：Antimicrobial agents and chemotherapy

authors： Jadeja L,Bolivar R,Fainstein V,Keating M,McCredie K,Hay M,Bodey GP

更新日期：1984-09-01 00:00:00

abstract：:Detailed analysis of the endogenous sterol content of purified Pneumocystis carinii preparations by gas-liquid chromatography coupled to mass spectrometry suggested that this parasite can both synthesize de novo steroid skeletons (to produce delta7 sterols) and take them from the infected host (leading to delta5 stero...

journal_title：Antimicrobial agents and chemotherapy

authors： Urbina JA,Visbal G,Contreras LM,McLaughlin G,Docampo R

更新日期：1997-07-01 00:00:00

abstract：:Many of the nitroaromatic agents used in medicine function as prodrugs and must undergo activation before exerting their toxic effects. In most cases, this is catalyzed by flavin mononucleotide (FMN)-dependent type I nitroreductases (NTRs), a class of enzyme absent from higher eukaryotes but expressed by bacteria and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Voak AA,Seifert K,Helsby NA,Wilkinson SR

更新日期：2014-01-01 00:00:00

abstract：:The apicomplexan parasites that cause malaria and babesiosis invade and proliferate within erythrocytes. To assess the potential for common antiparasitic treatments, we measured the sensitivities of multiple species of Plasmodium and Babesia parasites to the chemically diverse collection of antimalarial compounds in t...

journal_title：Antimicrobial agents and chemotherapy

authors： Paul AS,Moreira CK,Elsworth B,Allred DR,Duraisingh MT

更新日期：2016-07-22 00:00:00

abstract：:The efficacies of ciprofloxacin and ampicillin against Listeria monocytogenes in an immunosuppressed mouse model of listeriosis were compared. Immunosuppression was achieved by administration of 2.5 mg of hydrocortisone acetate daily. Both ciprofloxacin and ampicillin were effective in reducing the number of viable L....

journal_title：Antimicrobial agents and chemotherapy

authors： van Ogtrop ML,Mattie H,Sekh BR,van Strijen E,van Furth R

更新日期：1992-11-01 00:00:00

abstract：:The activities of ceftazidime-avibactam, ceftolozane-tazobactam, and comparators were evaluated for 733 isolates displaying resistance to broad-spectrum cephalosporins and carrying extended-spectrum β-lactamase (ESBL) genes detected by whole-genome sequencing analysis. Isolates were collected during 2017 in U.S. hospi...

journal_title：Antimicrobial agents and chemotherapy

authors： Castanheira M,Doyle TB,Mendes RE,Sader HS

更新日期：2019-06-24 00:00:00

abstract：:Escherichia coli sequence type 131 (ST131) is a pandemic clonal lineage that is responsible for the global increase in fluoroquinolone resistance and extended-spectrum-β-lactamase (ESBL) producers. The members of ST131 clade C, especially subclades C2 and C1-M27, are associated with ESBLs. We developed a multiplex con...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumura Y,Pitout JDD,Peirano G,DeVinney R,Noguchi T,Yamamoto M,Gomi R,Matsuda T,Nakano S,Nagao M,Tanaka M,Ichiyama S

更新日期：2017-07-25 00:00:00