Abstract：
:We reviewed 130 fine-needle aspiration (FNA) biopsies from 118 patients with a variety of benign and malignant hematopoietic lesions. There were 74 (57%) malignant, 45 (35%) benign, and 11 (8%) atypical diagnoses. Immunocytochemistry of the aspirated material was performed in 47 (36%) and electron microscopy in 4 (3%) of the cases. FNA cytology was utilized to make a primary hematopoietic malignant diagnosis in approximately half of the cases and to confirm recurrence in the remainder. The malignant cases included non-Hodgkin's lymphoma. Hodgkin's disease, medullary and extramedullary plasmacytoma, and granulocytic sarcoma. Forty-two malignant cases had either previous or follow-up surgical biopsy with no false-positive diagnoses. Of the 11 atypical cases, seven had surgical confirmation with five malignant and two benign diagnoses. The benign hematopoietic lesions correctly identified included acute and chronic lymphadenitis, granulomatous processes, and eosinophilic granuloma. Only 5 of the 45 benign FNA biopsies had surgical pathology follow-up, with no false-negative diagnoses. The most commonly aspirated sites were lymph nodes (71%), although hematopoietic lesions were correctly identified in a number of extranodal locations, including soft tissue (8%), abdominal viscera (6%), lungs (5%), mediastinum (2.5%), bone (3%), and thyroid, salivary gland, and breast (1.5% each). This study demonstrates the clinical utility and diagnostic accuracy of FNA cytology in the evaluation of benign and malignant hematopoietic disorders from multiple sites. Ancillary studies performed on the aspirated material aided in making a specific and accurate diagnosis.
journal_name
Diagn Cytopatholjournal_title
Diagnostic cytopathologyauthors
Silverman JF,McLeod DL,Park HKdoi
10.1002/dc.2840060406subject
Has Abstractpub_date
1990-01-01 00:00:00pages
252-7issue
4eissn
8755-1039issn
1097-0339journal_volume
6pub_type
杂志文章abstract：:The diagnosis of nodular sclerosing classical Hodgkin lymphoma (NSCHL) by fine-needle aspiration (FNA) biopsy has historically been a diagnostic challenge due to the usual paucicellularity of the specimen. This case report, and other previously published reports, suggests that there is another facet to the potentially...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.21829
更新日期：2014-03-01 00:00:00
abstract：:Adamantinoma-like Ewing Sarcoma (ALES) is a rare subtype of Ewing sarcoma family of tumors (EFTs) which are defined by their EWSR1 gene rearrangements. We present a case of a 15-year old female with a swelling in her anterior neck of 4 months duration which had recently begun to rapidly grow in size. Fine needle aspir...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.24467
更新日期：2020-05-30 00:00:00
abstract：:Lymphoepithelial cyst (LEC) of the pancreas is an extremely rare benign entity. We describe the cytopathologic findings of such a lesion in a 49-yr-old woman who was examined for epigastric pain. A trans-esophageal ultrasound-guided fine-needle aspiration of a pancreatic mass disclosed an intimate mixture of squamous ...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/(sici)1097-0339(199906)20:6<371::aid-dc8>3
更新日期：1999-06-01 00:00:00
abstract：:Multiple myeloma (MM) with central nervous system (CNS) infiltration is uncommon and the diagnosis is more complicated than that of MM. Here we report two cases of CNS MM that was diagnosed by cerebrospinal fluid cytology examination. Cerebrospinal fluid cytology examination can help to detect malignant cells and immu...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.23600
更新日期：2017-01-01 00:00:00
abstract：:Adenoviruses are emerging as important viral pathogens in immunocompromised patients due to immunodeficiency diseases and recently hematopoietic stem cell and solid organ transplant recipients, impacting morbidity and even mortality. Immunocompromised children are prone to respiratory infection, due to alterations in ...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.24662
更新日期：2020-11-16 00:00:00
abstract：:The development of procedures for fully automated processing of liquid-based gynecologic samples has been the focus of considerable interest to the cytology laboratory. Liquid-based collection and processing technology has been shown to improve sample adequacy, resulting in an overall improvement in quality of sample ...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.10193
更新日期：2002-11-01 00:00:00
abstract：:A 47-yr-old man with history of metastatic low-grade rectal leiomyosarcoma presented with progressive protrusion of his left eye due to an enlarging orbital mass. The differential diagnosis included tumor metastasis or orbital infection due to an unknown infectious agent. Diagnostic fine-needle aspiration (FNA) of the...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/(sici)1097-0339(199711)17:5<369::aid-dc10>
更新日期：1997-11-01 00:00:00
abstract：:The use of ultrasound-guided fine-needle aspiration (FNA) biopsy for nonpalpable breast lesions varies considerably. This retrospective study stresses the role of breast FNA in evaluating sonographically suspicious nonpalpable breast masses using a probabilistic reporting system. One hundred and eight consecutive ultr...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.20068
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:The International Academy of Cytology (IAC) Yokohama system is a recently proposed system for reporting breast cytology by fine needle aspiration biopsies (FNAB). Multiple studies are needed to confirm the risk of malignancy (ROM) of the various reporting categories of this system. The present article studie...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.24632
更新日期：2021-02-01 00:00:00
abstract：:Malignant small round cell tumors represent a diagnostic challenge for cytologists and pathologists. This case series describes four cases of unusual metastasis of small round cell tumors subtypes into body cavities generating effusions in which fluid cytological examination suggested the neuroendocrine origin of the ...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.21771
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Primary salivary gland-type tumors of the tracheobronchial tree are rare; their cytologic features have been seldom reported. We aim to describe the clinical and cytomorphologic features of tracheobronchial salivary gland-type tumors diagnosed by transbronchial fine needle aspiration (TBNA) at our institutio...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.24285
更新日期：2019-11-01 00:00:00
abstract：:Differential leukocyte counts on noninflammatory synovial fluids (NISF) are not widely reported or used in research, apparently due to technical difficulties related to either high viscosity or low numbers of cells. We describe an evaluation of a technique using hyaluronidase and cytospin preparations to study NISF. T...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/(sici)1097-0339(200004)22:4<256::aid-dc13>
更新日期：2000-04-01 00:00:00
abstract：:Malignant renal neoplasms are common solid tumors in pediatric oncology practice. These include the common Wilms' tumor/nephroblastoma and the uncommon neoplasms such as clear-cell sarcoma of the kidney (CCSK), rhabdoid tumor, renal-cell carcinoma, and others. The aim of this study was to describe in detail the cytopa...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.20242
更新日期：2005-05-01 00:00:00
abstract：:The Bethesda System for reporting cervical/vaginal diagnoses, introduced in this article, is a flexible guideline and can be modified as appropriate to meet the needs of cytopathologists, referring physicians, and patients. ...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.2840050318
更新日期：1989-01-01 00:00:00
abstract：:Synovial sarcomas (SS) of the head and neck region are extremely rare and arise in only 5% of cases. We present a case of secondary SS of the thyroid originally diagnosed as medullary carcinoma on fine needle aspiration (FNA). A 41-year-old man presented with several weeks of dysphonia and a left thyroid mass. FNA of ...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.23327
更新日期：2015-11-01 00:00:00
abstract：:Although fine-needle aspiration (FNA) cytologic features of conventional papillary thyroid carcinoma (PTC) and some of its variants have been documented in the literature, PTC with an adenoid cystic pattern has not so far been described. A 35-year-old woman presented with solitary cold nodule in the right lobe of thyr...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.20063
更新日期：2004-06-01 00:00:00
abstract：:The present study highlights the role of fine-needle aspiration cytology (FNAC) and Ziehl Neelsen (ZN) staining in diagnosis of cutaneous tuberculosis and correlates the cytomorphological features with histopathology.FNAC and biopsy was performed on 30 cases of cutaneous tuberculosis and along with the routine stains,...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.20534
更新日期：2006-12-01 00:00:00
abstract：:Ultrasound examination (US) is an essential tool in the evaluation of thyroid nodules. The size determined by US is used to distinguish between clinical vs. nonclinical thyroid nodules i.e. greater than or equal to or less than 1 cm. In this study, we evaluated the concordance between the sizes of thyroid nodules meas...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.20714
更新日期：2007-09-01 00:00:00
abstract：:Tenosynovial giant cell tumor (TSGCT) is a highly recurrent benign tumor of the extremities. Wide local excision is usually sufficient to achieve its recurrence-free outcome. However, that needs a confident pre-operative cytological diagnosis as TSGCT. Aspirates from this tumor express the characteristic polymorphic c...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.23825
更新日期：2018-03-01 00:00:00
abstract：:Five cases of mammary Paget's disease were diagnosed by nipple scrape cytology. The neoplastic material obtained was abundant in two cases, moderate in one, but in two, only a few cell aggregates feature in three cases and this, together with dense tumour cell cytoplasm and the background of keratinous debris, may imp...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.2840090309
更新日期：1993-01-01 00:00:00
abstract：:E-cadherin (E-CD) is a cell-adhesion molecule that has been associated with invasion and metastasis in a wide variety of human neoplasms. We have recently shown that, although decreased E-CD expression is associated with increased bladder-wall invasion and higher tumor grade of infiltrating transitional cell carcinoma...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/(SICI)1097-0339(199605)14:4<310::AID-DC6>3
更新日期：1996-06-01 00:00:00
abstract：:Ovarian tumors of sex-cord stromal derivation rarely exfoliate malignant cells in serous effusions. Adult granulosa cell tumor (AGCT) often presents as a stage I disease and association with ascites is about 10%. AGCT is rarely known to exfoliate tumor cells in the ascitic fluid. Exfoliation of malignant cells in the ...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.21675
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Since its inception in 1995, the Ultrafast Papanicoloau (UFPAP) cytological stain has undergone a number of modifications to suit the local availability of reagents and cost in different set ups. However, the reported results have been uniformly encouraging. We designed a study to investigate the inter-obser...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.23897
更新日期：2018-04-01 00:00:00
abstract：:Psammoma body is a rare finding in a cervicovaginal smear and can be associated with either benign or malignant diseases. Here we report a case to illustrate the association of psammoma bodies with benign granulomatous reactions to a foreign material (aluminum silicate). ...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/(sici)1097-0339(199908)21:2<122::aid-dc8>3
更新日期：1999-08-01 00:00:00
abstract：:Enterobiasis is one of the most common human parasitic infections. It is considered an intestinal parasite, but cases of extra-intestinal affections exist, notably infections of the female genital tract. Enterobius vermicularis (EV) eggs (or ova) have been found in the cervical smears of two patients in our institute ...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章,评审
doi：10.1002/dc.23812
更新日期：2018-02-01 00:00:00
abstract：:Cytodiagnosis of pulmonary hamartomas (PHs) by transthoracic fine-needle aspiration (FNA), successful in 11 of a series of 14 cases, has been found to rely less on the presence of mature cartilage than on the recognition of fibromyxoid fragments. These fragments, wispy yet discrete, consisting of variable numbers of f...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.2840050212
更新日期：1989-01-01 00:00:00
abstract：:Despite various reports of BK viral (BKV) DNA sequences or proteins in tumors of the urogenital tract, there has been no study statistically linking infection by this polyoma virus (PV) to tumor development. All PV are potential transforming viruses, the large T-antigen of which interacts with tumor suppressor protein...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.20429
更新日期：2006-03-01 00:00:00
abstract：:The largest series, to date, of fine-needle aspiration cytology (FNAC) findings in clear-cell sarcoma of the kidney (CCSK) is presented. All fine-needle aspirates of pediatric renal masses over a 17-yr period were reviewed. Eight out of 119 aspirates from late-stage childhood renal tumors (6.72%) were found to be CCSK...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.20317
更新日期：2005-08-01 00:00:00
abstract：:We have shown that SurePath when compared to conventional Paps fails to increase HSIL detection. In this study, assessment of test performance characteristics for the FocalPoint showed that sensitivity was 96% when manual screening was used as the "gold standard." When cervical biopsy, however, was used as the "gold s...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/dc.10373
更新日期：2003-11-01 00:00:00
abstract：:The diagnosis of T-cell lymphomas by fine-needle aspiration biopsies (FNAB) is extremely difficult. This is mainly due to the rarity of the disease, the morphologic similarity to reactive lymphadenopathy, and the difficulty in identifying abnormal T-cell antigen expression. We studied FNAB of histologically proven T-c...
journal_title：Diagnostic cytopathology
pub_type： 杂志文章
doi：10.1002/1097-0339(200012)23:6<375::aid-dc2>3.0.co;
更新日期：2000-12-01 00:00:00
