Significance of multiparameter flow cytometric analysis of ovarian cancer.

Abstract:

:A prospective flow cytometric examination of ovarian epithelial tumors was undertaken to further characterize aneuploid (including triploid and tetraploid) tumor cell populations according to expression of ovarian tumor antigen CA125 and to expression of class I (normally present in ovarian epithelium) and class II (normally absent in ovarian epithelium) major histocompatibility complex antigens. Samples from thirty-two of 42 patients (76%) exhibited at least one aneuploid population of tumor cells. Separate analysis of the aneuploid and diploid components of samples with aneuploid populations revealed between-tumor variation: seven of 23 aneuploid populations (30%) were positive for CA125; eight of 22 aneuploid populations (40%) exhibited substantial decreases in major histocompatibility complex class I expression, compared with corresponding diploid components of the same samples; and eight of 22 aneuploid populations (36%) exhibited substantial expression of major histocompatibility complex class II antigens. The frequencies of aneuploid populations and of the foregoing antigen expression categories were independent of tumor cell type, stage, and grade. The significance of these results for prognosis remains to be determined.

journal_name

Am J Obstet Gynecol

authors

Fowler WC Jr,Maddock MB,Moore DH,Haskill S

doi

10.1016/0002-9378(88)90081-6

subject

Has Abstract

pub_date

1988-04-01 00:00:00

pages

838-45

issue

4

eissn

0002-9378

issn

1097-6868

pii

0002-9378(88)90081-6

journal_volume

158

pub_type

杂志文章
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    doi:10.1016/0002-9378(75)90732-2

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    更新日期:1975-08-01 00:00:00

  • Comparison of suture materials for subcuticular skin closure at cesarean delivery.

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    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章,随机对照试验

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    authors: Nuwayhid B

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    authors: Granström L,Ekman G,Ulmsten U

    更新日期:1990-03-01 00:00:00

  • Immunoreactive gonadotropin-releasing hormone level in maternal circulation throughout pregnancy.

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  • Abnormal spinal curvature and its relationship to pelvic organ prolapse.

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    doi:10.1067/mob.2000.111489

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  • Medical and obstetric outcomes among pregnant women with tuberculosis: a population-based study of 7.8 million births.

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    journal_title:American journal of obstetrics and gynecology

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    doi:10.1016/j.ajog.2016.08.009

    authors: El-Messidi A,Czuzoj-Shulman N,Spence AR,Abenhaim HA

    更新日期:2016-12-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1998-06-01 00:00:00

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    pub_type: 杂志文章

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    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(77)90593-2

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    更新日期:1977-10-15 00:00:00

  • Determinants of the outcome of intrauterine insemination: analysis of outcomes of 9963 consecutive cycles.

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    pub_type: 杂志文章

    doi:10.1016/s0002-9378(99)70048-7

    authors: Stone BA,Vargyas JM,Ringler GE,Stein AL,Marrs RP

    更新日期:1999-06-01 00:00:00

  • Vasoactive intestinal polypeptide and other preprovasoactive intestinal polypeptide-derived peptides in the female and male genital tract: localization, biosynthesis, and functional and clinical significance.

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    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章,评审

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    authors: Ottesen B,Fahrenkrug J

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  • Robotic-assisted laparoscopic cerclage in a pregnant patient.

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    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2008.10.029

    authors: Fechner AJ,Alvarez M,Smith DH,Al-Khan A

    更新日期:2009-02-01 00:00:00

  • The relationship of blood lead levels to obstetric outcome.

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    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0002-9378(16)32282-7

    authors: Angell NF,Lavery JP

    更新日期:1982-01-01 00:00:00

  • Clinical, biochemical, and radiologic reversibility of hyperprolactinemic galactorrhea-amenorrhea and abnormal sella by thyroxine in a patient with primary hypothyroidism.

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    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0002-9378(16)33129-5

    authors: Tolis G,Hoyte K,McKenzie JM,Mason B,Robb P

    更新日期:1978-08-15 00:00:00

  • Restructuring residency training in obstetrics and gynecology.

    abstract::This essay presents a brief review of the history advocating a restructuring of residency training to increase the flexibility of the experience. The advantages for both the general obstetrician-gynecologist and the subspecialist are reviewed. ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1016/s0002-9378(99)70246-2

    authors: Bissonnette JM,Gabbe SG,Hammond CB,MacDonald PC,Polan ML,Roberts JM

    更新日期:1999-03-01 00:00:00

  • Eliminating health disparities in unintended pregnancy with long-acting reversible contraception (LARC).

    abstract::Significant public health disparities exist surrounding teen and unplanned pregnancy in the United States. Women of color and those with lower education and socioeconomic status are at much greater risk of unplanned pregnancy and the resulting adverse outcomes. Unplanned pregnancies reduce educational and career oppor...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ajog.2016.02.017

    authors: Parks C,Peipert JF

    更新日期:2016-06-01 00:00:00

  • A novel model of polyhydramnios: amniotic fluid volume is increased in aquaporin 1 knockout mice.

    abstract:OBJECTIVE:To test the hypothesis that amniotic fluid volume is increased in aquaporin 1 knockout mice. STUDY DESIGN:Transgenic mice deficient in aquaporin 1 protein were generated by targeted gene disruption, as described previously. After a cesarean section was performed, intact, individual gestational sacs were remo...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2005.02.046

    authors: Mann SE,Ricke EA,Torres EA,Taylor RN

    更新日期:2005-06-01 00:00:00

  • Prognostic factors in early invasive carcinoma of the uterine cervix. A clinical, histopathologic, and statistical analysis of 343 cases.

    abstract::Three hundred forty-three cases of early invasive carcinoma of the uterine cervix were analyzed. Depth of infiltration and lateral extension of the tumors varied between 0.2 and 9.0 mm and 0.4 and 17.2 mm and were found to be of no prognostic importance. A multivariate statistical analysis revealed several risk factor...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(83)91043-8

    authors: Larsson G,Alm P,Gullberg B,Grundsell H

    更新日期:1983-05-15 00:00:00

  • The experience with vaginal birth after cesarean delivery in a small rural community practice.

    abstract:OBJECTIVE:The purpose of this study was to determine if the success and safety of vaginal birth after cesarean delivery in a small, isolated, rural hospital compare with those seen in larger centers. STUDY DESIGN:As part of a continuing study, the prenatal and hospital records of all patients with previous cesarean de...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0002-9378(12)90885-6

    authors: Raynor BD

    更新日期:1993-01-01 00:00:00

  • Paraaortic lymph node sampling by means of an extraperitoneal approach with a supraumbilical transverse "sunrise" incision.

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    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(93)90080-3

    authors: Gallup DG,King LA,Messing MJ,Talledo OE

    更新日期:1993-08-01 00:00:00

  • Fixation of the vaginal apex to the coccygeus fascia during repair of vaginal vault eversion with enterocele.

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    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

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    更新日期:1995-06-01 00:00:00

  • Prenatal exposure to selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors and risk for persistent pulmonary hypertension of the newborn: a systematic review, meta-analysis, and network meta-analysis.

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    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章,meta分析

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    更新日期:2019-01-01 00:00:00

  • Pharmacologic levels of nitrendipine do not affect actin-myosin interaction in the human uterus and placenta.

    abstract::Because of the potential of dihydropyridine calcium channel blockers in the management of premature labor, we have studied the direct effects of nitrendipine on actomyosin in the pregnant and nonpregnant uterus and in the term human placenta. Actomyosin adenosinetriphosphatase in the three tissues and another model of...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(86)90679-4

    authors: Sakamoto H,Huszar G

    更新日期:1986-02-01 00:00:00

  • Trends in urodynamics study utilization in a Southern California managed care population.

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    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

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  • Burch colposuspension versus modified Marshall-Marchetti-Krantz urethropexy for primary genuine stress urinary incontinence: a prospective, randomized clinical trial.

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    pub_type: 临床试验,杂志文章,随机对照试验

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    journal_title:American journal of obstetrics and gynecology

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    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

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