Abstract:
BACKGROUND:It is currently believed that protein folding rates are influenced by protein structure, environment and temperature, amino acid sequence and so on. We have been working for long to determine whether and in what ways mRNA affects the protein folding rate. A large number of palindromes aroused our attention in our previous research. Whether these palindromes do have important influences on protein folding rates and what's the mechanism? Very few related studies are focused on these problems. OBJECTIVE:In this article, our motivation is to find out if palindromes have important influences on protein folding rates and what's the mechanism. METHODS:In this article, the parameters of the palindromes were defined and calculated, the linear regression analysis between the values of each parameter and the experimental protein folding rates were done. Furthermore, to compare the results of different kinds of proteins, proteins were classified into the two-state proteins and the multi-state proteins. For the two kinds of proteins, the above linear regression analysis were performed respectively. RESULTS:Protein folding rates were negatively correlated to the palindrome frequencies for all proteins. An extremely significant negative linear correlation appeared in the relationship between palindrome densities and protein folding rates. And the repeatedly used bases by different palindromes simultaneously have an important effect on the relationship between palindrome density and protein folding rate. CONCLUSION:The palindromes have important influences on protein folding rates, and the repeatedly used bases in different palindromes simultaneously play a key role in influencing the protein folding rates.
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Li R,Li H,Yang S,Feng Xdoi
10.2174/0929866526666191014144015subject
Has Abstractpub_date
2020-01-01 00:00:00pages
303-312issue
4eissn
0929-8665issn
1875-5305pii
PPL-EPUB-101420journal_volume
27pub_type
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