Monosomy 22 in rhabdoid or atypical tumors of the brain.

Abstract:

:Cytogenetic studies of three rare childhood brain tumors were performed. Two children presented with pure rhabdoid tumors. The third child had a tumor composed of a mixture of rhabdoid elements with neuroepithelial, epithelial, and mesenchymal tissue - an atypical teratoid tumor. All three tumors demonstrated monosomy 22 as the only cytogenetic abnormality. The cytogenetic findings suggest that loss of a gene or genes on chromosome 22 may be involved in the initiation or progression of these malignant tumors. Further studies on additional fresh tumor specimens are warranted; however, it is possible that cytogenetic studies may be used as an additional means of diagnosing rhabdoid or atypical teratoid tumors of the brain.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Biegel JA,Rorke LB,Packer RJ,Emanuel BS

doi

10.3171/jns.1990.73.5.0710

subject

Has Abstract

pub_date

1990-11-01 00:00:00

pages

710-4

issue

5

eissn

0022-3085

issn

1933-0693

journal_volume

73

pub_type

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