Key Determinants of the Value of Random Cervical Biopsy at Colposcopy.

Abstract:

OBJECTIVE:The aim of the study was to assess whether lower proportions of cervical intraepithelial neoplasia 2+ diagnosed by random biopsy are from lower cut points defining an abnormal colposcopic impression or obtaining only one random biopsy when colposcopic impression is normal. METHODS:We compared colposcopy experiences within Shanxi Province Cervical Cancer Screening Study (SPOCCS) (n = 1,383) and Shenzhen Cervical Cancer Screening Trial (SHENCCAST) (n = 631), which had instructive differences in the cut point defining an abnormal colposcopic impression. RESULTS:The proportion of CIN 2+ diagnosed by random biopsy in SPOCCS (35.0%, 141/403) was higher than SHENCCAST (18.4%, 35/190, p < .001). Quadrant-specific receiver operating characteristic curves for diagnosis of CIN 2+ by colposcopic impression in SPOCCS and SHENCCAST were similar; a lower cut point for an abnormal colposcopic impression in SHENCCAST resulted in lower proportion of CIN 2+ diagnosed by random biopsy. Normal colposcopic impression was found in 85.1% (120/141) of cases of CIN 2+ diagnosed by random biopsy in SPOCCS and in 57.1% (20/35) of such cases in SHENCCAST. Of CIN 2+ diagnosed by random cervical biopsy with normal colposcopic impression, one cervical quadrant was involved with CIN 2+ in 66.7% (80/120) of colposcopies in SPOCCS and 80% (16/20) of colposcopies in SHENCCAST. CONCLUSIONS:Colposcopy series with higher proportions of CIN 2+ diagnosed by random biopsy likely have more stringent cut points defining an abnormal colposcopic impression and have more random biopsies when the colposcopic impression is normal. At colposcopy, we advise multiple biopsies of all acetowhite epithelium or multiple random biopsies to increase the sensitivity of colposcopy.

journal_name

J Low Genit Tract Dis

authors

Pretorius RG,Belinson JL,Burchette RJ,Wu R,Qiao YL

doi

10.1097/LGT.0000000000000485

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

241-247

issue

4

eissn

1089-2591

issn

1526-0976

pii

00128360-201910000-00001

journal_volume

23

pub_type

杂志文章
  • Unusual location of vulvar basal cell carcinoma.

    abstract:BACKGROUND:Basal cell carcinoma (BCC) is a rare tumor of the vulva; it accounts for approximately 2% to 4% of vulvar cancer. CASE:A 73-year-old woman was referred because of a 2-cm ulcerative lesion on her perineum, near the anus. Punch biopsy showed BCC. She underwent wide local excision of tumor without any damage t...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/01.lgt.0000225898.37090.04

    authors: Nazari Z,Omranipour R

    更新日期:2006-10-01 00:00:00

  • Unusual locations of primary subepithelial squamous cell carcinomas of the vulva.

    abstract:OBJECTIVE:This study aimed to report 2 cases of squamous cell carcinoma (SCC) of the vulva, arising from unusual subepithelial locations. MATERIALS AND METHODS:The first case was of an 85-year-old woman with a 65-year history of a mass in the left labium majus. The second case was of a 54-year-old woman who presented ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31827a8c95

    authors: Scurry JP,Yu TT,Otton GR

    更新日期:2013-10-01 00:00:00

  • Allergic Contact Dermatitis of the Anogenital Region in Men and Women.

    abstract:OBJECTIVES:Allergic contact dermatitis is an uncommon but important cause of skin disease in the anogenital region. Relevant allergens are described in women and less commonly in men. The aim of this study was to describe outcomes of patch testing in men and women presenting with anogenital dermatoses. MATERIALS AND M...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000516

    authors: Cheng HS,Fernández-Peñas P

    更新日期:2020-04-01 00:00:00

  • Incidence of cervical intraepithelial neoplasia in Estonia.

    abstract:OBJECTIVE:This study aimed to assess the incidence of cervical intraepithelial neoplasia (CIN) by grade (CIN 1, CIN 2, CIN 3) and age in Estonia (a country with less developed cervical cancer screening program and high cervical cancer incidence). MATERIALS AND METHODS:This descriptive study uses data from a health ins...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3182652213

    authors: Uusküla A,Raag M,Uppin A,Raud T,Klaar U,Jürisson M,Müürsepp A

    更新日期:2013-04-01 00:00:00

  • Clinicopathologic features and treatment outcomes of primary extramammary Paget disease of the vulva.

    abstract:OBJECTIVE:The aim of this study was to identify the clinicopathologic features and treatment outcome of primary extramammary Paget disease of the vulva (EMPDV). MATERIALS AND METHODS:We performed a retrospective analysis of 14 patients who were treated at our center from April 1994 to November 2010. RESULTS:The mean ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000063

    authors: Nomura H,Matoda M,Okamoto S,Kondo E,Omatsu K,Kato K,Takeshima N

    更新日期:2015-04-01 00:00:00

  • Human Papillomavirus Same Genotype Persistence and Risk: A Systematic Review.

    abstract:OBJECTIVE:The aim of the study was to examine whether high-grade cervical intraepithelial neoplasia (CIN) was more closely associated with human papillomavirus (HPV) same-genotype persistence (SGTP) versus clearance of prior infection with a subsequent infection by a new genotype (genotype switch [GS]), clearance of HP...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000573

    authors: Bonde J,Bottari F,Iacobone AD,Cocuzza CE,Sandri MT,Bogliatto F,Khan KS,Ejegod DM,Gary DS,Andrews JC

    更新日期:2021-01-01 00:00:00

  • Differences in cervical cytologic and histologic findings between women using depot-medroxyprogesterone acetate and oral contraceptives.

    abstract:OBJECTIVE:This study aimed to compare cervical cytologic and histologic findings between women using depot-medroxyprogesterone acetate (DMPA) and oral contraceptives (OCs) referred for colposcopy and to determine whether there were differences in the occurrence of false-positive cytologic finding between the 2 contrace...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31820eb140

    authors: Clark MK,Stockdale CK,Railsback L,Nichols S

    更新日期:2011-07-01 00:00:00

  • Association of Body Mass Index With Adherence to Cervical Cancer Screening Recommendations in Hispanic Women.

    abstract:OBJECTIVE:Obese women have higher cervical cancer incidence and mortality than their counterparts, possibly related to nonadherence to screening recommendations. We assessed the association of body mass index with adherence to cervical cancer screening recommendations in Hispanic women living in Puerto Rico, a minority...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000504

    authors: Pérez CM,González-Barrios D,Ramos-Cartagena JM,Ortiz AP

    更新日期:2020-01-01 00:00:00

  • Vulvovaginal candidiasis in postmenopausal women: the role of hormone replacement therapy.

    abstract:OBJECTIVE:: This study aimed to explore the role of hormone replacement therapy (HRT) in susceptibility to vulvovaginal candidiasis (VVC) in a private vulval disease referral practice. METHODS:: Between January 2009 and December 2010, 149 healthy, nondiabetic patients with vulvar conditions were compared for significa...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3182241f1a

    authors: Fischer G,Bradford J

    更新日期:2011-10-01 00:00:00

  • Is colposcopy warranted in women with external anogenital warts?

    abstract::OBJECTIVES.: To determine the prevalence of cervical dysplasia, diagnosed cytologically (squamous intraepithelial lesion [SIL]) or histologically (cervical intraepithelial neoplasia [CIN]), in women with external anogenital warts, and to determine the discriminating risk factors between those with and without cervical...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/00128360-200301000-00006

    authors: Li J,Rousseau MC,Franco EL,Ferenczy A

    更新日期:2003-01-01 00:00:00

  • Natural history of low-grade squamous intraepithelial lesion.

    abstract:OBJECTIVE:To determine guidelines for management of CIN1 by evaluating its natural history. METHODS:One hundred fifty-eight patients were diagnosed with CIN1 had colposcopy follow-up with or without cytology every three months. RESULTS:Colposcopically directed biopsy confirmed progression to CIN2 or CIN3 in 17 of 158...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:

    authors: Saw HS,Lee JK,Lee HL,Jee HJ,Hyun JJ

    更新日期:2001-07-01 00:00:00

  • Home study course: spring 2007.

    abstract:OBJECTIVE:The Home Study Course is intended for the practicing colposcopist or practitioner who is seeking to develop or enhance his/her colposcopic skills. The goal of the course is to present colposcopic cases that are unusual or instructive in terms of appearance, presentation, or management, or that demonstrate new...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/lgt.0b013e3180380fd3

    authors: Mitchell KJ,Flowers L

    更新日期:2007-04-01 00:00:00

  • Management of adenocarcinoma in situ of the uterine cervix: a comparison of loop electrosurgical excision procedure and cold knife conization.

    abstract:OBJECTIVE:This study aimed to compare loop electrosurgical excision procedure (LEEP) with cold knife conization (CKC) as therapeutic management procedures for women with adenocarcinoma in situ (ACIS) of the cervix. METHODS:We conducted a retrospective chart review of all patients who underwent a conization procedure w...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000055

    authors: Latif NA,Neubauer NL,Helenowski IB,Lurain JR

    更新日期:2015-04-01 00:00:00

  • Yield and mode of diagnosis of cervical intraepithelial neoplasia 3 or cancer among women with negative cervical cytology and positive high-risk human papillomavirus test results.

    abstract:OBJECTIVE:In women with negative cervical cytology and positive high-risk human papillomavirus (HR-HPV) test results, we compared the risk of cervical intraepithelial neoplasia 3 (CIN 3) or cancer (CIN 3+) in women with previous abnormal cervical cytology, CIN, or HR-HPV with that in women without this history, and we ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e318281f182

    authors: Pretorius RG,Belinson JL,Peterson P,Azizi F,Lo A

    更新日期:2013-10-01 00:00:00

  • Presence of Spontaneous Pain and Comorbid Pain Conditions Identifies Vulvodynia Subgroups.

    abstract:OBJECTIVE:The aims of the study were to define the heterogeneity of vulvodynia by determining data-driven subgroups within the vulvodynia diagnosis using exploratory cluster analysis and to characterize the subgroups identified. MATERIALS AND METHODS:Included were participants in the longitudinal population-based stud...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000166

    authors: Reed BD,Plegue MA,Williams DA,Sen A

    更新日期:2016-01-01 00:00:00

  • Post-Loop Electrosurgical Excision Procedure High-Risk Human Papillomavirus Testing as a Test of Cure: The British Columbia Experience.

    abstract:OBJECTIVES:To determine whether Hybrid Capture 2 High-Risk HPV DNA Test (HC2) can be used as a test of cure in women treated for cervical intraepithelial neoplasia grade 2 or worse (CIN 2+) and allow discharge from colposcopy follow-up with a return to a cytology-based screening program for HC2-negative women. MATERIA...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000349

    authors: Ceballos KM,Lee M,Cook DA,Smith LW,Gondara L,Krajden M,van Niekerk DJ,Coldman AJ

    更新日期:2017-10-01 00:00:00

  • Contribution of Exocervical Biopsy, Endocervical Curettage, and Colposcopic Grading in Diagnosing High-Grade Cervical Intraepithelial Neoplasia.

    abstract:OBJECTIVE:To determine the utility of random biopsy and endocervical curettage (ECC) during colposcopy among women who ultimately underwent cervical excisional biopsy. MATERIALS AND METHODS:In a retrospective observational study, the charts were reviewed of every patient who underwent cervical excisional procedure per...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3182a5296e

    authors: Diedrich JT,Felix JC,Lonky NM

    更新日期:2016-01-01 00:00:00

  • Fact or Fiction? Adipose-Derived Stem Cells and Platelet-Rich Plasma for the Treatment of Vulvar Lichen Sclerosus.

    abstract:OBJECTIVE:The aim of the study was to summarize and review the evidence for the efficacy and safety of adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus (LS). MATERIALS AND METHODS:PubMed/MEDLINE, Ovid, Web of Science, and clinicaltrials.gov were searched fr...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,评审

    doi:10.1097/LGT.0000000000000440

    authors: Eshtiaghi P,Sadownik LA

    更新日期:2019-01-01 00:00:00

  • Interpretability of excisional biopsies of the cervix: cone biopsy and loop excision.

    abstract:OBJECTIVE:To compare the results of cold knife conization (CKC) and loop electrosurgical excision procedure (LEEP) for cervical intraepithelial neoplasia to determine if excisional method has effects on pathologic interpretation. METHODS:Retrospective review of the perioperative medical records of patients who had a C...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31817ff940

    authors: Miroshnichenko GG,Parva M,Holtz DO,Klemens JA,Dunton CJ

    更新日期:2009-01-01 00:00:00

  • The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology.

    abstract::The terminology for human papillomavirus (HPV)-associated squamous lesions of the lower anogenital tract has a long history marked by disparate diagnostic terms derived from multiple specialties. It often does not reflect current knowledge of HPV biology and pathogenesis. A consensus process was convened to recommend ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,评审

    doi:10.1097/LGT.0b013e31825c31dd

    authors: Darragh TM,Colgan TJ,Cox JT,Heller DS,Henry MR,Luff RD,McCalmont T,Nayar R,Palefsky JM,Stoler MH,Wilkinson EJ,Zaino RJ,Wilbur DC,Members of LAST Project Work Groups.

    更新日期:2012-07-01 00:00:00

  • A case report of disseminated tuberculosis: an unsuspected uterine cervical mass in a young native american woman with new-onset seizure disorder.

    abstract::Disseminated tuberculosis involving the uterine cervix and central nervous system is described in a 26-year-old Native American female with new-onset seizures. Her presenting complaint was generalized seizures with associated weight loss, chronic cough, global headache, and malaise. Pelvic examination revealed an exop...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1046/j.1526-0976.1999.08099.x

    authors: Kern TW,Waxman AG,Kilgo R,Tempest B

    更新日期:1999-04-01 00:00:00

  • Vulvovaginal pyoderma gangrenosum secondary to rituximab therapy.

    abstract::Rituximab is being used increasingly for the treatment of B-cell malignancies and nonmalignant conditions. Pyoderma gangrenosum is a rare neutrophilic dermatosis, which can be either idiopathic or associated with underlying systemic inflammatory conditions. We present a series of 4 patients who presented with ulcerati...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000043

    authors: Dixit S,Selva-Nayagam P,Hamann I,Fischer G

    更新日期:2015-01-01 00:00:00

  • Vaginal Stenosis After Gonadotropin-Releasing Hormone Agonist Therapy During Treatment for Acute Lymphoblastic Leukemia.

    abstract::A 26-year-old patient with a history of chemotherapy for acute lymphoblastic leukemia presented with secondary amenorrhea and cyclic abdominal pain, and she was found to have vaginal stenosis due to adhesion of vaginal wall. The cause of the adhesion was considered to be vaginal inflammation induced by anticancer agen...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000175

    authors: Sato M,Harada M,Oishi H,Wada-Hiraike O,Hirata T,Nagasaka K,Koga K,Fujii T,Osuga Y

    更新日期:2016-04-01 00:00:00

  • A rare case of ectopic adrenocorticotropic hormone syndrome in small cell carcinoma of the vagina: a case report.

    abstract:OBJECTIVE:To describe ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) to increase awareness of this condition when treating patients with gynecological small cell carcinoma (SmCC). MATERIALS AND METHODS:This is a review of a 61-year-old woman with primary vaginal SmCC and an atypical presentation of Cushing ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31815cda1e

    authors: Weberpals J,Djordjevic B,Khalifa M,Oza A

    更新日期:2008-04-01 00:00:00

  • Emphysematous vaginitis.

    abstract:BACKGROUND:Emphysematous vaginitis is a rare condition, characterized by the presence of multiple gas-filled cysts in the vaginal and/or exocervical mucosa. Although its etiology is not completely understood, it is self-limited, with a benign clinical course. Vaginal discharge, sometimes bloody, and pruritus are the mo...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000092

    authors: Lima-Silva J,Vieira-Baptista P,Cavaco-Gomes J,Maia T,Beires J

    更新日期:2015-04-01 00:00:00

  • High Rates of High-Grade Cervical Dysplasia in High-Risk Young Women With Low-Grade Cervical Cytology.

    abstract:OBJECTIVE:The aim of the study was to determine rates of cervical intraepithelial neoplasia (CIN) 2 or greater in high-risk, racially diverse, young women with low-grade cytology. MATERIALS AND METHODS:After institutional review board approval, a cross-sectional study of 21- to 24-year-old women with low-grade cytolog...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000381

    authors: Daily LR,Erickson BK,Pasko DN,Straughn JM Jr,Huh WK,Leath CA 3rd

    更新日期:2018-07-01 00:00:00

  • Conservative treatment of microinvasive adenocarcinoma of uterine cervix: long-term follow-up.

    abstract:UNLABELLED:OBIECTIVE: This study aimed to evaluate the safety of conservative treatment in women desiring preservation of fertility with stage IA adenocarcinoma of the cervix. MATERIALS AND METHODS:Clinical report of all women with stage IA adenocarcinoma of the cervix, endocervical subtype, with clear margins on cone...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3182446b3a

    authors: Sopracordevole F,Canzonieri V,Giorda G,De Piero G,Lucia E,Campagnutta E

    更新日期:2012-10-01 00:00:00

  • Assessment of Anal Cancer Screening Tools in Detecting High-Grade Anal Squamous Intraepithelial Lesions in Women.

    abstract:OBJECTIVE:The aim of the study was to evaluate the validity of anal cytology against high-resolution anoscopy in the detection of anal high-grade squamous intraepithelial lesions (HSILs) among women in a clinical setting in Puerto Rico, alone and in combination with high-risk human papillomavirus (HR-HPV) typing. MATE...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000497

    authors: Ramos-Cartagena JM,Pérez CM,Guiot HM,Amaya-Ardilla CP,Tirado-Gómez M,Ortiz AP

    更新日期:2020-01-01 00:00:00

  • Performance of the Affirm VP-III using residual vaginal discharge collected from the speculum to characterize vaginitis in symptomatic women.

    abstract:OBJECTIVE:To evaluate the ability of collecting the Affirm VP-III test sample using the residual vaginal discharge found on the speculum. METHODS AND METHODS:One hundred nine symptomatic women (≥18 y) participated in this study. During pelvic examination, vaginal fluid was collected onto 3 swabs for office-based diagn...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000025

    authors: Mulhem E,Boyanton BL Jr,Robinson-Dunn B,Ebert C,Dzebo R

    更新日期:2014-10-01 00:00:00

  • Abnormal pap tests and human papillomavirus infections among HIV-infected and uninfected women who have sex with women.

    abstract:OBJECTIVE:To estimate the frequency of abnormal Pap and human papillomavirus (HPV) positivity among human immunodeficiency virus (HIV)-seropositive and -seronegative women who have sex with women (WSW). METHODS:Pap and HPV DNA polymerase chain reaction tests were obtained every 6 months from women in a US cohort of HI...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,多中心研究

    doi:10.1097/LGT.0b013e3182942733

    authors: Massad LS,Xie X,Minkoff H,Darragh TM,D'Souza G,Sanchez-Keeland L,Watts DH,Colie C,Strickler HD

    更新日期:2014-01-01 00:00:00