Central arterial stiffness and retinal vessel calibers: the Atherosclerosis Risk in Communities Study-Neurocognitive Study.

abstract：OBJECTIVE:To assess the effect of orlistat plus diet compared with diet alone in promoting weight loss and blood pressure reduction in hypertensive, overweight/obese patients. DESIGN:A pragmatic randomized, controlled trial. SETTING:Hypertension clinic of a university hospital. PATIENTS:Hypertensive patients aged 18...

journal_title：Journal of hypertension

authors： Bloch KV,Salles GF,Muxfeldt ES,Da Rocha Nogueira A

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Bradykinin is a potent cardioprotective hormone, the beneficial role of which in vivo appears to be limited by its rapid metabolism. Inhibitors of peptidases that degrade endogenously formed bradykinin are themselves cardioprotective, presumably by increasing local bradykinin concentrations. As bradykinin-de...

journal_title：Journal of hypertension

authors： Taylor-McCabe KJ,Erşahin C,Simmons WH

更新日期：2001-07-01 00:00:00

abstract：AIM:Studies addressing the association between a reduced drop of heart rate (HR) at night with subclinical organ damage and cardiovascular events in the general population are scanty. We evaluated this issue in individuals enrolled in the Pressioni Monitorate E Loro Associazioni study. METHODS:At entry, 2021 individua...

journal_title：Journal of hypertension

authors： Cuspidi C,Facchetti R,Bombelli M,Sala C,Tadic M,Grassi G,Mancia G

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:Increased endothelial production of reactive oxygen species and decreased nitric oxide bioactivity, associated with the upregulation of monocyte chemoattractant protein (MCP)-1 and lectin-like oxidized low-density lipoprotein receptor (LOX)-1, link hypertension with atherogenesis. We investigated whether the...

journal_title：Journal of hypertension

authors： Zhou MS,Schulman IH,Jaimes EA,Raij L

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVES:To determine whether 'slow pressor' hypertension from systemic angiotensin (Ang II) infusion was associated with renal vascular structural remodeling of the renal resistance vessels and glomerulus. METHODS:Ang II (4.5-10 ng/kg per min) or vehicle was infused for 10 days. Renal resistance vascular lumen chan...

journal_title：Journal of hypertension

authors： Edgley AJ,Kett MM,Anderson WP

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:To investigate cardiomyocyte hypertrophy and hormonal profile in cardiac hypertrophy resulting from sequentially applied overloads. METHODS:We studied Sprague-Dawley rats with renovascular hypertension (RV), where pressure overload predominates, or deoxycorticosterone acetate (DOCA)-salt (DS), where volume o...

journal_title：Journal of hypertension

authors： Cavallero S,González GE,Puyó AM,Rosón MI,Pérez S,Morales C,Hertig CM,Gelpi RJ,Fernández BE

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:End-stage renal disease (ESRD) is characterized by markedly increased sympathetic outflow that contributes to increased cardiovascular mortality in these patients. The central sympatholytic drug moxonidine (MOX) has been shown to reduce muscle sympathetic nerve activity (MSNA) in initial stages of chronic kid...

journal_title：Journal of hypertension

authors： Hausberg M,Tokmak F,Pavenstädt H,Krämer BK,Rump LC

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:We investigated the responses of mean arterial pressure and renal blood flow to intravenous and intrarenal angiotensin II, plasma and kidney angiotensin II concentrations and renal angiotensin receptor subtype 1 protein expression, and renal functional responses to intravenous and intrarenal angiotensin recep...

journal_title：Journal of hypertension

authors： Kopkan L,Kramer HJ,Husková Z,Vanourková Z,Skaroupková P,Thurmová M,Cervenka L

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVES:To investigate the influence of angiotensin II (All) receptors in isolated hepatic nuclei on other genes regulated by All and to determine whether the function of these intracellular receptors is influenced by alterations in the endocrine renin system. METHODS:Nuclei were isolated from hepatic tissue of nor...

journal_title：Journal of hypertension

authors： Eggena P,Zhu JH,Sereevinyayut S,Giordani M,Clegg K,Andersen PC,Hyun P,Barrett JD

更新日期：1996-08-01 00:00:00

abstract：AIMS:In order to eventually improve blood pressure (BP) management, the aim of this study was to identify subgroups of type 2 diabetes mellitus (T2DM) patients with distinct trajectories of SBP levels. Identifying subgroups with distinct SBP trajectories helps to better understand the course of SBP levels in T2DM patie...

journal_title：Journal of hypertension

authors： Walraven I,Mast MR,Hoekstra T,Jansen AP,Rauh SP,Rutters FR,van der Heijden AA,Elders PJ,Moll AC,Polak BC,Dekker JM,Nijpels G

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:Epidemiological studies suggest that intrauterine growth restriction (IUGR) due to maternal undernutrition during pregnancy represents a major risk factor for hypertension and diabetes in adult age. However, placental insufficiency, rather than maternal malnutrition, is the main cause of IUGR in the Western w...

journal_title：Journal of hypertension

authors： Jansson T,Lambert GW

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Enhanced mechanical forces, e.g. in arterial hypertension, stimulate the formation of reactive oxygen species (ROS) by the NAD(P)H oxidase. Since bone marrow derived endothelial progenitor cells (EPCs) contribute to vascular remodeling and repair, we investigated whether renovascular hypertension stimulates ...

journal_title：Journal of hypertension

authors： Salguero G,Akin E,Templin C,Kotlarz D,Doerries C,Landmesser U,Grote K,Schieffer B

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Cerebrovascular myogenic function, which protects the brain from hemorrhagic stroke, is impaired in stroke-prone spontaneously hypertensive rats. Furthermore, myogenic function contributes to very low frequency blood pressure variability and dynamic autoregulation of cerebral blood flow is most effective at ...

journal_title：Journal of hypertension

authors： Stauss HM,Petitto CE,Rotella DL,Wong BJ,Sheriff DD

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Hypertension is a complex trait with an ill-defined genetic predisposition, in which adrenergic mechanisms seem to be involved even at the early stages. Chromogranin A is a pro-hormone stored and released with catecholamines by exocytosis; its fragment catestatin, formed in vivo, inhibits further catecholami...

journal_title：Journal of hypertension

authors： O'Connor DT,Kailasam MT,Kennedy BP,Ziegler MG,Yanaihara N,Parmer RJ

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:To examine the associations among hypertension, insulin secretion, glucose tolerance and insulin resistance in vivo. DESIGN:Glucose tolerance and insulin secretion during an intravenous glucose tolerance test and action of insulin on whole-body glucose kinetics in the post-absorptive state and during hyperin...

journal_title：Journal of hypertension

authors： Holness MJ,Sugden MC

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:Hypertension is a major risk factor for cardiovascular disease. Polymorphism in the beta2-adrenergic receptor (ADRB2) and nitric oxide synthase 3 (NOS3) genes is associated with clinical cardiovascular phenotypes. The Arg16Gly and Glu298Asp polymorphisms of ADRB2 and NOS3 genes, respectively, have been report...

journal_title：Journal of hypertension

authors： Misono M,Maeda S,Iemitsu M,Nakata Y,Otsuki T,Sugawara J,Zempo H,Yoshizawa M,Miyaki A,Kuno S,Matsuda M,Ajisaka R

更新日期：2009-07-01 00:00:00

abstract：:Vascular Na-K pump activity (ouabain-sensitive 86Rb uptake) and cardiac Na,K-ATPase activity are decreased in rats with one-kidney, one clip and reduced renal mass-saline hypertension. In the present study we measured left ventricular, microsomal Na,K-ATPase activity in rats with two steroid forms of hypertension; one...

journal_title：Journal of hypertension

authors： Clough DL,Pamnani MB,Haddy FJ

更新日期：1984-04-01 00:00:00

abstract：:Uptake of 45Ca was measured in rings of thoracic aorta from rabbits with hypertension, induced by cellophane perinephritis (Page hypertension: one-kidney, one wrap). Basal 45Ca uptake was increased significantly in the hypertensive group (sham: 100 +/- 3, hypertensive: 133 +/- 11 nmol/g wet weight, n = 6). 45Ca uptake...

journal_title：Journal of hypertension

authors： Dong Y,Wadsworth RM

更新日期：1987-12-01 00:00:00

abstract：OBJECTIVES:Current clinical guidelines of primary aldosteronism recommend adrenalectomy (AdX) for unilateral primary aldosteronism based on the studies showing the potential superiority of AdX over the medical treatment. However, since most medically treated cases consisted of bilateral primary aldosteronism and all su...

journal_title：Journal of hypertension

authors： Katabami T,Fukuda H,Tsukiyama H,Tanaka Y,Takeda Y,Kurihara I,Ito H,Tsuiki M,Ichijo T,Wada N,Shibayama Y,Yoshimoto T,Ogawa Y,Kawashima J,Sone M,Inagaki N,Takahashi K,Fujita M,Watanabe M,Matsuda Y,Kobayashi H,Shib

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:Low insulin sensitivity is closely related to both cardiovascular diseases and diabetes development. Still, correlates of insulin sensitivity have mainly been examined in cross-sectional studies. As far as we are aware, the longitudinal stability of insulin sensitivity in young men is largely unknown. We aime...

journal_title：Journal of hypertension

authors： Skårn SN,Flaa A,Kjeldsen SE,Rostrup M,Brunborg C,Reims HM,Fossum E,Høieggen A,Aksnes TA

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Elevated plasma glucocorticoid level is an independent predictor of increased mortality risk in chronic heart failure, but local biosynthesis and pathophysiological roles of glucocorticoids in the heart remain unclear. METHODS:Dahl salt-sensitive rats on high-salt diet and mice with transthoracic aortic ban...

journal_title：Journal of hypertension

authors： Ohtani T,Mano T,Hikoso S,Sakata Y,Nishio M,Takeda Y,Otsu K,Miwa T,Masuyama T,Hori M,Yamamoto K

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:To describe several emerging concepts regarding the biosynthesis, metabolism and biological roles of adenosine and to illustrate the possible significance of these ideas to vascular biology by proposing a hypothesis pertaining to the role of erythrocyte-derived adenosine deaminase in vaso-occlusive diseases a...

journal_title：Journal of hypertension

authors： Jackson EK,Koehler M,Mi Z,Dubey RK,Tofovic SP,Carcillo JA,Jones GS

更新日期：1996-01-01 00:00:00

abstract：:The purpose of the present study was to characterize the etiology of bilateral perinephritis hypertension in the non-human primate. Hypertension was induced in female cynomolgus (Macaca fascicularis) monkeys by wrapping both kidneys under sterile surgical procedures. Mean arterial pressure (MAP), plasma renin activity...

journal_title：Journal of hypertension

authors： DeForrest JM,Scalese RJ,Oehl RS,Waldron TL,Mitch S,Brittain RJ,Free CA,Asaad M,Burkett D

更新日期：1989-09-01 00:00:00

abstract：:The binding of 125I-angiotensin II to human blood cells was investigated. Blood was drawn from healthy volunteers and platelets prepared with minimal contamination of red cells and white blood cells (less than 0.1%). Using thin layer chromatography, degradation of 125I-angiotensin II by platelets could be demonstrated...

journal_title：Journal of hypertension

authors： Mann JF,Sis J,Ritz E

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:High sleep blood pressure (BP) has been suggested to be an independent risk factor for cardiovascular outcomes. To assess the applicability of sleep BP measured using a timer-equipped home device, we investigated the association between home device-measured sleep BP and large artery stiffness. METHODS:We pe...

journal_title：Journal of hypertension

authors： Tabara Y,Matsumoto T,Murase K,Setoh K,Kawaguchi T,Kosugi S,Nakayama T,Hirai T,Wakamura T,Chin K,Matsuda F,Nagahama study group.

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Secondary prevention of stroke with antihypertensive drugs is now standard practice, but it is unclear how soon after a cerebrovascular event antihypertensive therapy should be initiated or re-started. Due to impaired cerebral autoregulation, changes in systemic blood pressure may be reflected in cerebral pe...

journal_title：Journal of hypertension

authors： Nazir FS,Overell JR,Bolster A,Hilditch TE,Reid JL,Lees KR

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVES:Previous studies have demonstrated that the time rate of blood pressure (BP) variation was associated with early carotid atherosclerosis, independent of peripheral and central BP levels. We evaluated the association between the rate of BP variation, derived from ambulatory BP monitoring (ABPM) data analysis,...

journal_title：Journal of hypertension

authors： Manios E,Stamatelopoulos K,Tsivgoulis G,Barlas G,Koroboki E,Tsagalis G,Michas F,Vemmos K,Zakopoulos N

更新日期：2011-06-01 00:00:00

abstract：:The effects of age on the circadian blood pressure rhythm of patients with untreated essential hypertension (n = 133, World Health Organization stage I or II) were compared with those of normotensive subjects (n = 91). Subjects were classified into three groups by age: young (less than 40 years old), adult (40-59 year...

journal_title：Journal of hypertension

authors： Munakata M,Imai Y,Abe K,Sasaki S,Minami N,Hashimoto J,Sakuma H,Ichijo T,Yoshizawa M,Sekino H

更新日期：1991-05-01 00:00:00

abstract：OBJECTIVE:An excess morning blood pressure surge (MBPS) may portend an increased cardiovascular risk, but the mechanisms thereof have been little investigated. The link between MBPS, short-term blood pressure (BP) variability, and arterial stiffness has not been entirely defined. METHODS:In 602 consecutive untreated h...

journal_title：Journal of hypertension

authors： Pucci G,Battista F,Anastasio F,Schillaci G

更新日期：2017-02-01 00:00:00

abstract：:: Altered blood pressure (BP) is a common phenomenon in acute ischemic stroke (AIS), with high BP being the most frequent scenario. The pathophysiology of BP changes in AIS is complex and only partially understood. The available evidence indicates that extremely high BP during AIS is associated with a poor outcome. Im...

journal_title：Journal of hypertension

authors： Gąsecki D,Coca A,Cunha P,Hering D,Manios E,Lovic D,Zaninelli A,Sierra C,Kwarciany M,Narkiewicz K,Karaszewski B

更新日期：2018-06-01 00:00:00