Management of Clostridioides difficile Infection.

Abstract:

CLINICAL RELEVANCE:Clostridioides (formerly Clostridium) difficile infection is among the most identified causes of health care-associated infections in US hospitals and remains a major public health problem. The incidence and severity of C difficile infection are high among critically ill patients. Treating critically ill patients is challenging; treatment failure is especially common because of comorbidities and the continued need for antibiotic therapy for other infections. Because of the high risk of C difficile infection recurrence and high mortality rate associated with the disease, intensive research has taken place over the last decade to improve patient outcomes. This research has resulted in new drugs indicated for C difficile infection and new information on existing drugs. The 2010 clinical practice guidelines for C difficile infections have been updated on the basis of this new information. PURPOSE OF PAPER:To review the 2017 update of the clinical practice guidelines from the Society for Health-care Epidemiology of America and the Infectious Diseases Society of America. CONTENT COVERED:The updated recommendations for the treatment of C difficile infection, the clinical pharmacology of old and new drugs for treating the infection, and the role of critical care nurses in mini-mizing the risk of C difficile infection for their patients.

journal_name

Crit Care Nurse

journal_title

Critical care nurse

authors

Clarkin C,Quist S,Shamis R,King AE,Shah BM

doi

10.4037/ccn2019841

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

e1-e12

issue

5

eissn

0279-5442

issn

1940-8250

pii

39/5/e1

journal_volume

39

pub_type

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