MiR-142 inhibits lung cancer cell proliferation and promotes apoptosis by targeting XIAP.

Abstract:

OBJECTIVE:The X-linked inhibitor of apoptosis protein (XIAP) is associated with the development of various tumors. The abnormal miR-142 expression is associated with the onset of lung cancer. Bioinformatics analysis revealed a targeted relationship between miR-142 and XIAP. This report investigated whether miR-142 plays a role in regulating XIAP expression and affecting the biological processes of lung cancer cells. PATIENTS AND METHODS:The tumor tissues of lung cancer patients were collected, and the adjacent tissues were used as controls. The dual luciferase reporter gene assay validated the targeted regulation between miR-142 and XIAP. Using BEAS-2B cells as control, qRT-PCR was used to detect the expression of miR-142 and XIAP in lung cancer cells A549 and H1650. Lung cancer H1650 cells were cultured and divided into miR-NC group and miR-142 mimic group followed by an analysis of cell proliferation by EdU staining. RESULTS:Compared with those in adjacent tissues, miR-142 expression was significantly decreased and XIAP expression was increased in lung cancer tissues. The Dual-Luciferase Reporter Assay confirmed a targeted regulation relationship between miR-142 and XIAP. Compared with BEAS-2B cells, miR-142 expression in lung cancer A549 and H1650 cells was significantly decreased, and XIAP expression was significantly increased. Transfection of miR-142 mimic significantly inhibited the expression of XIAP in H1650 cells, promoted apoptosis and inhibited cell proliferation. CONCLUSIONS:Decreased miR-142 expression and increased XIAP expression is associated with the onset of lung cancer. MiR-142 can inhibit lung cancer cell proliferation and induce apoptosis through inhibition of XIAP expression.

authors

Wu XB,Li QH,Zhang N,Li M,Li K

doi

10.26355/eurrev_201909_18852

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

7430-7437

issue

17

eissn

1128-3602

issn

2284-0729

journal_volume

23

pub_type

杂志文章
  • MicroRNA-551b expression profile in low and high-grade cervical intraepithelial neoplasia.

    abstract:OBJECTIVE:To evaluate the expression of microRNA (miR)-551b in patients with low and high grade cervical intraepithelial neoplasia (CIN) and to find an association with high-risk Human Papillomavirus (HR-HPV) infection-related prognostic biomarkers. PATIENTS AND METHODS:The expression level of miR-551b was determined ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201807_15496

    authors: Lukic A,Di Properzio M,Carico E,De Vitis C,Giglio S,Bordi G,Caserta D,Mancini R

    更新日期:2018-07-01 00:00:00

  • Vaginal natural oxygenation device (VNOD) for concomitant administration of hyaluronic acid and topical hyperbaric oxygen to treat vulvo-vaginal atrophy: a pilot study.

    abstract:OBJECTIVE:This is a pilot study to evaluate the effectiveness of concomitant administration of hyaluronic acid and topical hyperbaric oxygen therapy (THOT) by a specifically designed medical device (vaginal natural oxygenation device, VNOD) in improving the symptomatology of postmenopausal patients with vulvo-vaginal a...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201812_16548

    authors: Condemi L,Di Giuseppe J,Delli Carpini G,Garoia F,Frega A,Ciavattini A

    更新日期:2018-12-01 00:00:00

  • Intranasal drug administration for procedural sedation in children admitted to pediatric Emergency Room.

    abstract:OBJECTIVE:Pain relief is a very important aspect in Pediatrician's clinical practice. It is often thought that young children, particularly infants, do not perceive as much pain as adults because of their immature nervous system and that untreated pain would not have adverse long-term consequences. Instead, it has been...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.26355/eurrev_201801_14120

    authors: Fantacci C,Fabrizio GC,Ferrara P,Franceschi F,Chiaretti A

    更新日期:2018-01-01 00:00:00

  • Pneumocystis jirovecii pneumonia in a human immunodeficiency virus-infected patient with G6PD deficiency-successful treatment with anidulafungin.

    abstract:CASE REPORT:We reported a HIV-infected patient, diagnosed as PJP with G6PD deficiency. Pneumocystis jiroveci pneumonia (PJP) is the most common opportunistic infection in subjects with human immunodeficiency virus (HIV) infection. Trimethoprim-sulfamethoxazole (TMP-SMX) is the first line regimen for Pneumocystis jirove...

    journal_title:European review for medical and pharmacological sciences

    pub_type:

    doi:10.26355/eurrev_201812_16666

    authors: Chang HC,Yang WT,Chen TC

    更新日期:2018-12-01 00:00:00

  • Effects of vitamin D levels on asthma control and severity in pre-school children.

    abstract:OBJECTIVE:Prevalence of asthma and vitamin D deficiency has been increasing and leading to significant morbidities. This study aimed to compare the vitamin D levels in the pre-school children with asthma and in healthy controls and to assess the relationship between vitamin D levels and asthma clinical parameters and c...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Turkeli A,Ayaz O,Uncu A,Ozhan B,Bas VN,Tufan AK,Yilmaz O,Yuksel H

    更新日期:2016-01-01 00:00:00

  • Ambroxol alleviates ventilator-induced lung injury by inhibiting c-Jun expression.

    abstract:OBJECTIVE:Ventilator-induced lung injury (VILI) remains a challenge. This study was designed to investigate the effects of ambroxol on VILI and the underlying mechanisms in a rodent model. MATERIALS AND METHODS:Male Wistar rats weighing 310-380 g were divided into four groups (n=8 per group): 1) saline only, 2) ventil...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201906_18092

    authors: Cao DW,Hou MX,Zhang XR

    更新日期:2019-06-01 00:00:00

  • IMP3 promotes TNBC stem cell property through miRNA-34a regulation.

    abstract:OBJECTIVE:To explore the expression and function of insulin-like growth factor II (IGFII) mRNA binding protein (IMP3) in the Triple Negative Breast Cancer (TNBC). MATERIALS AND METHODS:According to previously reported gene expression array, we found that IMP3 had significantly higher expression in the CD44+CD24-ESA+ c...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201805_14965

    authors: Huang QD,Zheng SR,Cai YJ,Chen DL,Shen YY,Lin CQ,Hu XQ,Wang XH,Shi H,Guo GL

    更新日期:2018-05-01 00:00:00

  • Effect of miR-21/TLR4/NF-κB pathway on myocardial apoptosis in rats with myocardial ischemia-reperfusion.

    abstract:OBJECTIVE:The aim of the study was to investigate the influences of micro ribonucleic acid (miR)-21 and downstream Toll-like receptor 4 (TLR4)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway on myocardial apoptosis induced by myocardial ischemia-reperfusion (I/R) injury in rats. MATERIAL...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201811_16420

    authors: Pan YQ,Li J,Li XW,Li YC,Li J,Lin JF

    更新日期:2018-11-01 00:00:00

  • HDAC1 is indirectly involved in the epigenetic regulation of p38 MAPK that drive the lung cancer progression.

    abstract:OBJECTIVE:p38 MAPK are a class of protein kinase that may induce or prevent apoptosis in different circumstance. Emerging researches show that it plays a vital role in tumor progression and therefore understanding its dual role in different stages of lung cancer are important to investigate. Also in this study, we plan...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201809_15932

    authors: Dong ZY,Zhou YR,Wang LX

    更新日期:2018-09-01 00:00:00

  • Correlation between microRNA-766 expression in patients with advanced gastric cancer and the efficacy of platinum-containing chemotherapy.

    abstract:OBJECTIVE:We aimed at observing the correlation between microRNA-766 expression and the efficacy of platinum-containing chemotherapy in patients with stage IV gastric cancer (GCa). PATIENTS AND METHODS:Tissue specimens were obtained from 100 patients with stage IV GCa who received platinum-based chemotherapy, and micr...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202009_22821

    authors: Xue YF,Xue D,Yao B,Hu CG,Liu J

    更新日期:2020-09-01 00:00:00

  • The pure effects of obstructive sleep apnea syndrome on cardiac autonomic functions: heart rate turbulence analysis.

    abstract:OBJECTIVES:To demonstrate the pure effect of obstructive sleep apnea syndrome (OSAS) on cardiac autonomic function (CAF) using heart rate turbulence (HRT) parameters. PATIENTS AND METHODS:A total of 64 patients with OSAS and 30 age- and gender-matched healthy subjects were enrolled. All subjects had normal coronary ar...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Erdem A,Dogan OT,Yontar OC,Epozturk K,Ozlu MF,Ozturk S,Ayhan SS,Erdem FH,Yazici M,Akkurt I,Talay F

    更新日期:2013-10-01 00:00:00

  • lncRNA MEG3 inhibit proliferation and metastasis of gastric cancer via p53 signaling pathway.

    abstract:OBJECTIVE:lncRNA MEG3 has been reported as a tumor suppressor gene in many different kinds of cancer, but its role in gastric cancer has not been fully understood. Then, we would like to explore its mechanism in gastric cancer. PATIENTS AND METHODS:We first used qRT-PCR to detect the expression of lncRNA MEG3, then CC...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Wei GH,Wang X

    更新日期:2017-10-01 00:00:00

  • Cervical Intraepithelial Neoplasia (CIN) in pregnancy: the state of the art.

    abstract:OBJECTIVES:Cervical cancer is the most commonly diagnosed malignancy in pregnancy and cervical screening should be accordingly performed in this particular situation. Occurrence of a preneoplastic cervical disease in pregnancy has for a long time represented a challenge for the clinician, both in terms of diagnostic ac...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Origoni M,Salvatore S,Perino A,Cucinella G,Candiani M

    更新日期:2014-01-01 00:00:00

  • Mediastinal parathyroid adenoma: a case report.

    abstract::Ectopic parathyroid adenomas represent a diagnostic challenge, since they are quite rare in clinical practice. We present a case of a 61 years old man with symptomatic hypercalcemia due to an ectopic parathyroid adenoma in the upper-anterior mediastinum that was not localized by the scintigraphy. Ultrasonography ident...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Di Cosimo C,Metere A,Chiesa C,Di Rocco G,Trulli F,Paciaroni A,Battaglia S,Redler A,Fierro G,Giacomelli L

    更新日期:2012-06-01 00:00:00

  • Significance of LncRNA KCNQ1OT1 expression in diagnosis and prognosis judgment of myelodysplastic syndrome.

    abstract:OBJECTIVE:To study the expression level of the long non-coding ribonucleic acid (lncRNA) KCNQ1 overlapping transcript 1 (KCNQ1OT1) in the patients with myelodysplastic syndrome (MDS), as well as the correlation between the expression level of lncRNA KCNQ1OT1 and the clinical diagnosis and prognosis of MDS. PATIENTS AN...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202005_21341

    authors: Zhang SF,Jin L,Chen YF

    更新日期:2020-05-01 00:00:00

  • Is visiting Qom spread CoVID-19 epidemic in the Middle East?

    abstract::The CoVID-19 epidemic started in Wuhan, China and spread to 217 other countries around the world through direct contact with patients, goods transfer, animal transport, and touching unclean surfaces. In the Middle East, the first confirmed case in both Iran and UAE originated from China. A series of infections since t...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202005_21376

    authors: Al-Rousan N,Al-Najjar H

    更新日期:2020-05-01 00:00:00

  • Comparison of plasma antioxidant levels in middle-aged and old male with idiopatic osteoporosis: preliminary data.

    abstract:OBJECTIVES:With the purpose of evaluating the role of oxidative stress (OS) in male idiopatic osteoporosis, we have evaluated plasma total antioxidant capacity (TAC) in patients classified according to age (< 65 or ≥ 65 yrs), with normal hormone values and in age-matched healthy control subjects. PATIENTS AND METHODS:...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Mancini A,Raimondo S,Di Segni C,Persano M,Di Geronimo E,Silvestrini A,Pontecorvi A,Meucci E,Tamburrelli FC

    更新日期:2014-01-01 00:00:00

  • Risk factors for mortality in severe multiply injury patients with acute hypoxemic respiratory failure.

    abstract:OBJECTIVE:To investigate the risk factors related to mortality in severe polytrauma patients with acute hypoxemic respiratory failure (AHRF). PATIENTS AND METHODS:From December 2011 to December 2014, we identified and intubated 524 traumatic AHRF patients in a level 1 trauma centers. Amongst those, we enrolled seventy...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Chen YD,Feng XL,Deng L,Zhou P,Wang JD,Cai B,Jiang H,Dong Y,Zhang XH

    更新日期:2015-10-01 00:00:00

  • Anaphylaxis from peanut oil in infant feedings and medications.

    abstract::Peanut is a very dangerous allergen. Too often one is unaware that peanut allergens can be found everywhere, hidden in a myriad of foods, and without any indication of their presence. It is stressed that not even infant feedings and medications can be exempt, thus leading to anaphylaxis. ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Cantani A

    更新日期:1998-09-01 00:00:00

  • Effects of Ulinastatin on myocardial oxidative stress and inflammation in severely burned rats.

    abstract:OBJECTIVE:By constructing the severe burns model in rat, we explored the effects of different doses of Ulinastatin (UTI) on protecting myocardium from oxidative stress and inflammatory reaction. MATERIALS AND METHODS:The severe burns model in rat was first constructed. Burned rats were intervened with different doses ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201809_15840

    authors: He F,Song Y,Ying WJ,Jin XY,Wang ZX,Su JD,Wang GY

    更新日期:2018-09-01 00:00:00

  • Effects of miR-132 on proliferation and apoptosis of pancreatic cancer cells via Hedgehog signaling pathway.

    abstract:OBJECTIVE:Micro ribonucleic acids (miRNAs) and Hedgehog (Hh) signaling pathway play key roles in the proliferation, migration and invasion of tumor cells. The aim of this study was to investigate the role of miR-132 and Hh signaling pathway in the proliferation and apoptosis of pancreatic cancer cells, and to investiga...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201903_17236

    authors: Zhao DW,Hou YS,Sun FB,Han B,Li SJ

    更新日期:2019-03-01 00:00:00

  • Unusual cause of adult intussusception: diffuse large B-cell non-Hodgkin's lymphoma: a case report and review.

    abstract:BACKGROUND:Intussusception is defined as the telescoping of a segment of the gastrointestinal tract into an adjacent one. A demonstrable etiology is found in 70% to 90% of cases in adult patients, and about 40% of them are caused by a primary or secondary malignant tumor. The aims of this study were to give an overview...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Akbulut S

    更新日期:2012-12-01 00:00:00

  • Glutamine has a protective role on intestinal tissues via targeting NF-κB pathway in rats with sepsis.

    abstract:OBJECTIVE:To study the protective effect of glutamine on the intestinal tissues of septic rats by regulating the nuclear factor-κB (NF-κB) pathway. MATERIALS AND METHODS:A total of 30 rats were divided into the Sham group, Model group, and Glutamine group using a random number table. The changes in the intestinal tiss...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201908_18646

    authors: Wu TY,Zhang HB

    更新日期:2019-08-01 00:00:00

  • Anti IgE antibody as treatment of allergic bronchopulmonary aspergillosis in a patient with cystic fibrosis.

    abstract::Allergic bronchopulmonary aspergillosis (ABPA) occurs in 7-9% of patients with cystic fibrosis (CF) and causes a worsening of lung function and respiratory symptoms. Standard treatment of ABPA consists of oral steroids; however, higher corticosteroid therapy associated to antifungal agent (itraconazole) long-term trea...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Zicari AM,Celani C,De Castro G,Valerio De Biase R,Duse M

    更新日期:2014-07-01 00:00:00

  • Effect of ALK-inhibitors in the treatment of non-small cell lung cancer: a systematic review and meta-analysis.

    abstract:OBJECTIVE:Lung cancer is the leading cause of cancer-related mortality. Over 80% of all lung cancer cases are non-small-cell lung cancer (NSCLC) and approximately 5% of NSCLC patients are positive for anaplastic lymphoma kinase (ALK) gene rearrangement or fusion with echinoderm microtubule-associated protein-like 4 (EM...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章,meta分析,评审

    doi:

    authors: Li G,Dai WR,Shao FC

    更新日期:2017-08-01 00:00:00

  • Clinical outcomes after resectoscopic treatment of cesarean-induced isthmocele: a prospective case-control study.

    abstract:OBJECTIVE:Isthmocele represents a reservoir on the anterior wall of the uterine isthmus or of the cervical canal at the site of a previous cesarean delivery scar. Recently, it has been clarified that it might be the cause of several gynecologic symptoms, as most common abnormal uterine bleeding. Hysteroscopy and trans-...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Muzii L,Domenici L,Lecce F,Di Feliciantonio M,Frantellizzi R,Marchetti C,Monti M,Benedetti Panici P

    更新日期:2017-08-01 00:00:00

  • Serum and exosomal hsa_circ_0000907 and hsa_circ_0057362 as novel biomarkers in the early diagnosis of diabetic foot ulcer.

    abstract:OBJECTIVE:Diabetic foot ulcer (DFU) is a serious chronic complication leading to disability and death in patients suffering from diabetes. Currently, there is no effective marker for its early diagnosis. The aim of this study is to analyze the difference of circRNA expression profiles between DFU and normal human wound...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202008_22498

    authors: Chen ZJ,Shi XJ,Fu LJ,Liu J,Shi K,Zhang WB,Su PK

    更新日期:2020-08-01 00:00:00

  • MiR-221 affects proliferation and apoptosis of gastric cancer cells through targeting SOCS3.

    abstract::Since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, "MiR-221 affects proliferation and apoptosis of gastric cancer cells through targeting SOCS3, by Q.-Y. Zhou, P.-L. Peng, Y.-H. Xu, published in Eur Rev Med...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202007_22226

    authors: Zhou QY,Peng PL,Xu YH

    更新日期:2020-07-01 00:00:00

  • Licorice and its active compound glycyrrhizic acid ameliorates cisplatin-induced nephrotoxicity through inactivation of p53 by scavenging ROS and overexpression of p21 in human renal proximal tubular epithelial cells.

    abstract:OBJECTIVE:Nephrotoxicity is one of the major side effects that limit the use of cisplatin in cancer therapy. Cisplatin-induced apoptosis in renal cells is associated with reactive oxygen species (ROS)-mediated p53 activation. Licorice (Glycyrrhiza uralensis Fischer) is one of the most widely used medicinal herbs in Kor...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Ju SM,Kim MS,Jo YS,Jeon YM,Bae JS,Pae HO,Jeon BH

    更新日期:2017-02-01 00:00:00

  • Deflazacort treatment of cystoid macular edema in patients affected by Retinitis Pigmentosa: a pilot study.

    abstract:BACKGROUND:To investigate the efficacy of a long-term treatment with Deflazacort (DFZ), a third generation synthetic glucocorticoid, in patients affected by Retinitis Pigmentosa (RP) complicated by Cystoid Macular Edema (CME). METHODS:A randomized group of 10 RP subjects were selected for this pilot study and treated ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Giusti C,Forte R,Vingolo EM

    更新日期:2002-01-01 00:00:00