Abstract:
:Enteroviruses (EV) are responsible for a large number of meningoencephalitis cases, especially in children. The objective of this study was to identify modes of diagnosis including the significance of respiratory and cerebrospinal fluid samples, associated clinical characteristics, inpatient management, and outcome of individuals with EV infections of the central nervous system (CNS). Electronic medical records of individuals with enterovirus infections of the CNS who presented to the Columbia University Irving Medical Center and Children's Hospital of New York between January 1, 2012 and December 31, 2017 were reviewed retrospectively for demographic, epidemiological, and clinical data. The median age overall was 1.7 months (interquartile range 14 years) and most (62.4%) were male. The majority of CNS infections presented as meningitis (95.7%) and occurred in the summer (45.2%) and fall seasons (37.6%). Eighty-five cases (91.4%) demonstrated EV positivity in cerebrospinal fluid, thirty cases (32.3%) exhibited both cerebrospinal fluid and respiratory positivity, and eight cases (8.6%) exhibited respiratory positivity with coinciding neurological findings. Eighty-nine individuals overall (95.7%) received antibiotics and 37 (39.8%) received antiviral treatment. All surviving individuals had favorable Modified Rankin Scores (MRS) within the zero to two ranges upon discharge. Testing respiratory samples in addition to cerebrospinal fluid was found to be an important diagnostic tool in EV-associated cases. While clinical outcomes were favorable for an overwhelming majority of cases, etiological understanding of CNS infections is essential for identifying ongoing and changing epidemiological patterns and aid in improving the diagnosis and treatment.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Torres SD,Jia DT,Schorr EM,Park BL,Boubour A,Boehme A,Ankam JV,Gofshteyn JS,Tyshkov C,Green DA,Vargas W,Zucker J,Yeshokumar AK,Thakur KTdoi
10.1007/s13365-019-00784-5subject
Has Abstractpub_date
2020-02-01 00:00:00pages
14-22issue
1eissn
1355-0284issn
1538-2443pii
10.1007/s13365-019-00784-5journal_volume
26pub_type
杂志文章abstract::We examined murine hepatitis virus strain A59 (MHV-A59)-induced demyelinating disease in C57BL/6 mice which had previously been thymectomized at 25 days of age. Demyelination was observed in 51-96% of spinal cord quadrants examined 30 or 60 days post infection (dpi), indicating that neither an intact thymus nor thymic...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289709018297
更新日期:1997-06-01 00:00:00
abstract::Pseudorabies virus (PRV) primarily infects swine but can infect cattle, dogs, and cats. Several studies have reported that PRV can cross the specie barrier and induce human encephalitis, but a definitive diagnosis of human PRV encephalitis is debatable due to the lack of PRV DNA detection. Here, we report a case of hu...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-019-00822-2
更新日期:2020-06-01 00:00:00
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journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
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abstract::Recent studies on the coreceptor usage of human immunodeficiency virus (HIV) strains associated with acquired immunodeficiency syndrome (AIDS) dementia have shown that both X4 and R5 viruses are involved in the process. The disease is associated with enhanced virus replication and monocyte chemoattractant protein (MCP...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/753312763
更新日期:2004-01-01 00:00:00
abstract::Distal leg epidermal nerve fiber density (ENFD) is a validated predictor of HIV sensory neuropathy (SN) risk. We assessed how ENFD is impacted by initiation of first-time antiretroviral therapy (ART) in subjects free of neuropathy and how it is altered when mitochondrial toxic nucleoside medications are used as part o...
journal_title:Journal of neurovirology
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doi:10.1007/s13365-015-0352-0
更新日期:2015-10-01 00:00:00
abstract::The mechanisms underlying central nervous system (CNS) toxicities in antiretroviral-treated persons living with HIV (PLWH) remain elusive. We investigated the associations between markers of tryptophan metabolism and measurements of CNS toxicity in PLWH. In a prospective study, virologically suppressed PLWH receiving ...
journal_title:Journal of neurovirology
pub_type: 杂志文章,多中心研究
doi:10.1007/s13365-018-0688-3
更新日期:2019-02-01 00:00:00
abstract::Clinical or laboratory evidence of varicella-zoster virus (VZV) infection has been consistently associated with lower glioma risk in case-control studies, suggesting a protective effect of VZV against glioma. We formulated the following explanatory hypotheses: reactivated VZV preferentially infects and kills gliomas c...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-011-0048-z
更新日期:2011-10-01 00:00:00
abstract::After uniocular anterior chamber (AC) inoculation of herpes simplex virus type 1 (HSV-1), virus and TNF alpha (TNF-alpha) are detected in the suprachiasmatic nuclei (SCN). The goal of this study was to investigate the role of TNF-alpha and macrophages in the brain of HSV-1-infected BALB/c mice. Mice were treated with ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280601039030
更新日期:2006-12-01 00:00:00
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289509113968
更新日期:1995-06-01 00:00:00
abstract::A study of neuropsychological performance was conducted in 33 HIV+ patients initiating highly active antiretroviral therapy (HAART). Grooved Pegboard (GP) non-dominant hand performance improved in 23/33 (70%) subjects (P=0.002). Among 23 patients with motor slowing (GP non-dominant hand z score < -1.0) at baseline, 18...
journal_title:Journal of neurovirology
pub_type: 临床试验,杂志文章
doi:10.3109/13550280009006385
更新日期:2000-02-01 00:00:00
abstract::The cerebral immune response induced by herpes simplex virus (HSV) encephalitis (HSE) was evaluated in susceptible BALB/c and resistant C57BL/6 mice. BALB/c and C57BL/6 (named C57BL/6-high) mice were respectively infected intranasally with 1 × 103 and 5 × 105 plaque-forming units (PFUs) of HSV-1. C57BL/6 mice (named C...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-019-00730-5
更新日期:2019-06-01 00:00:00
abstract::A subset of patients with coronavirus 2 disease (COVID-19) experience neurological complications. These complications include loss of sense of taste and smell, stroke, delirium, and neuromuscular signs and symptoms. The etiological agent of COVID-19 is SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), an R...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-020-00903-7
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280802345715
更新日期:2008-11-01 00:00:00
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journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-014-0285-z
更新日期:2014-12-01 00:00:00
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-014-0257-3
更新日期:2014-08-01 00:00:00
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journal_title:Journal of neurovirology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2000-05-01 00:00:00
abstract::There is controversy with regard to the entry pathway of the rabies virus (RABV) into the central nervous system (CNS). Some authors have suggested that the virus inoculated at the periphery is captured and transported to CNS only by motor neurons; however, it has been reported that dorsal root ganglia (DRG) sensory n...
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journal_title:Journal of neurovirology
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journal_title:Journal of neurovirology
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doi:10.1080/13550280390173319
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289909021998
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289909015816
更新日期:1999-06-01 00:00:00
abstract::Like human immunodeficiency virus (HIV), feline immunodeficiency virus (FIV) invades and infects the central nervous system (CNS) soon after peripheral infection. The appearance of viral RNA is particularly prominent in the cerebrospinal fluid (CSF), suggesting an efficient route of virus transfer across the blood-CSF...
journal_title:Journal of neurovirology
pub_type: 杂志文章
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abstract::Human immunodeficiency virus type 1 (HIV-1) and viral proteins affect neuronal survival and neuron-glial cell interactions, which culminate in neurological disorders. HIV-1 infects regions of neurogenesis in human adult and pediatric brain. However, little is known about the effect of HIV-1 or viral proteins on the pr...
journal_title:Journal of neurovirology
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journal_title:Journal of neurovirology
pub_type: 杂志文章
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journal_title:Journal of neurovirology
pub_type: 杂志文章
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journal_title:Journal of neurovirology
pub_type: 杂志文章
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journal_title:Journal of neurovirology
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