Abstract:
:A stability-indicating assay procedure for the determination of norethindrone on the surface of Red Delicious apple slices was developed. The apple slice is homogenized in pH 10 borate buffer solution and norethindrone is then partitioned into chloroform using a diffusion chamber that has a membrane that is permeable to hydrophobic compounds separating the buffer and chloroform. An aliquot of the chloroform extract is then evaporated to dryness and reconstituted in tetrahydrofuran. The reconstituted sample is then chromatographed on a C18 reversed-phase column using a mobile phase consisting of water:tetrahydrofuran:methanol (63:26:11, v/v/v). Detection is in the UV range at 254 nm. The chromatographic system is specific for norethindrone in the presence of its autoxidation products. Stability data indicate that norethindrone is stable for up to 6 h on the surface of Red Delicious apples.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Mayberry DO,Kowblansky M,Lane PA,Wray PEdoi
10.1002/jps.2600790818subject
Has Abstractpub_date
1990-08-01 00:00:00pages
746-9issue
8eissn
0022-3549issn
1520-6017pii
S0022-3549(15)48315-7journal_volume
79pub_type
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