The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages.

abstract：:In less than 3 months after the first cases of swine origin 2009 influenza A (H1N1) virus infections were reported from Mexico, WHO declared a pandemic. The pandemic virus is antigenically distinct from seasonal influenza viruses, and the majority of human population lacks immunity against this virus. We have studied ...

journal_title：Journal of virology

authors： Osterlund P,Pirhonen J,Ikonen N,Rönkkö E,Strengell M,Mäkelä SM,Broman M,Hamming OJ,Hartmann R,Ziegler T,Julkunen I

更新日期：2010-02-01 00:00:00

abstract：:We have investigated the molecular basis of biological differences observed among cell line-adapted isolates of the human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and the simian immunodeficiency virus (SIV) in response to receptor binding by using a soluble form of CD4 (sCD4) as a receptor mimic. We find...

journal_title：Journal of virology

authors： Sattentau QJ,Moore JP,Vignaux F,Traincard F,Poignard P

更新日期：1993-12-01 00:00:00

abstract：:Three monkeypox virus (MPV) antibody-secreting murine monoclones were characterized as being of the immunoglobulin G1 isotype, gave a 4+ reaction in the indirect fluorescent-antibody test, gave a positive reaction in the enzyme immunoassay, and did not neutralize MPV. These monoclonal antibodies were determined by the...

journal_title：Journal of virology

authors： Roumillat LF,Patton JL,Davis ML

更新日期：1984-10-01 00:00:00

abstract：:Reciprocal three-factor crosses and the use of a partial revertant of a putative ribonucleotide reductase mutant of Escherichia coli B/5 as indicator have made it possible to map denA (deficient in endonuclease II) between nrd-11 (ribonucleotide reductase gene B) and amM69 (gene 63) on the bacteriophage T4 chromosome....

journal_title：Journal of virology

authors： Ray P,Sinha NK,Warner HR,Snustad DP

更新日期：1972-01-01 00:00:00

abstract：:The lymphoid cell line #1670 has been derived from the infiltrated spleen of a tumor-bearing marmoset monkey infected with Herpesvirus saimiri. The cells contain both types of H. saimiri DNA, unique light (L-) DNA (36% cytosine plus guanine) and repetitive heavy (H-) DNA (71% cytosine plus guanine), without producing ...

journal_title：Journal of virology

authors： Werner FJ,Bornkamm GW,Fleckenstein B

更新日期：1977-06-01 00:00:00

abstract：:Infection of cells with enveloped viruses is accomplished through membrane fusion. The binding and fusion processes are mediated by the spike proteins in the envelope of the virus particle and usually involve a series of conformational changes in these proteins. We have studied the low-pH-mediated fusion process of th...

journal_title：Journal of virology

authors： Wahlberg JM,Bron R,Wilschut J,Garoff H

更新日期：1992-12-01 00:00:00

abstract：:The gH/gL complex plays an essential role in virus entry and cell-cell spread of herpes simplex virus (HSV). Very few immunologic reagents were previously available to either identify important functional regions or gain information about structural features of this complex. Therefore, we generated and characterized a...

journal_title：Journal of virology

authors： Cairns TM,Shaner MS,Zuo Y,Ponce-de-Leon M,Baribaud I,Eisenberg RJ,Cohen GH,Whitbeck JC

更新日期：2006-03-01 00:00:00

abstract：:This study examines the persistence and fitness of multidrug-resistant (MDR) viruses acquired during primary human immunodeficiency virus infection (PHI). In four individuals, MDR infections persisted over the entire study period, ranging from 36 weeks to 5 years, in the absence of antiretroviral therapy. In stark con...

journal_title：Journal of virology

authors： Brenner BG,Routy JP,Petrella M,Moisi D,Oliveira M,Detorio M,Spira B,Essabag V,Conway B,Lalonde R,Sekaly RP,Wainberg MA

更新日期：2002-02-01 00:00:00

abstract：:Purified nuclei from polyoma-infected mouse (3T3) cells were found to be greatly reduced in their ability to synthesize viral DNA in vitro when compared with a crude system consisting of an unfractionated hypotonic lysate of the infected cells. The synthetic capacity of the nuclei could be fully reconstituted when a h...

journal_title：Journal of virology

authors： Francke B,Hunter T

更新日期：1975-01-01 00:00:00

abstract：:During lytic infection, herpes simplex virus type 1 (HSV-1) represses host transcription, recruits RNA polymerase II (RNAP II) to viral replication compartments, and alters the phosphorylation state of the RNAP II large subunit. Host transcription repression and RNAP II modifications require expression of viral immedi...

journal_title：Journal of virology

authors： Jenkins HL,Spencer CA

更新日期：2001-10-01 00:00:00

abstract：:Infection of receptor-bearing cells by coronaviruses is mediated by their spike (S) proteins. The coronavirus (SARS-CoV) that causes severe acute respiratory syndrome (SARS) infects cells expressing the receptor angiotensin-converting enzyme 2 (ACE2). Here we show that codon optimization of the SARS-CoV S-protein gene...

journal_title：Journal of virology

authors： Moore MJ,Dorfman T,Li W,Wong SK,Li Y,Kuhn JH,Coderre J,Vasilieva N,Han Z,Greenough TC,Farzan M,Choe H

更新日期：2004-10-01 00:00:00

abstract：:We have examined the pattern of RNA transcription on the L (late) DNA strand late in the simian virus 40 virus infectious cycle by separating pulse-labeled RNA chains according to size and hybridizing to an ordered series of DNA fragments obtained by restriction enzyme digestion. From this analysis, the 5' end of the ...

journal_title：Journal of virology

authors： Ford JP,Hsu MT

更新日期：1978-12-01 00:00:00

abstract：:The human cytomegalovirus UL47 open reading frame encodes a 110-kDa protein that is a component of the virion tegument. We have constructed a cytomegalovirus mutant, ADsubUL47, in which the central portion of the UL47 open reading frame has been replaced by two marker genes. The mutant replicated to titers 100-fold lo...

journal_title：Journal of virology

authors： Bechtel JT,Shenk T

更新日期：2002-02-01 00:00:00

abstract：:The importance of neutralizing antibodies (NAbs) in protection against hepatitis C virus (HCV) remains controversial. We infused a chimpanzee with H06 immunoglobulin from a genotype 1a HCV-infected patient and challenged with genotype strains efficiently neutralized by H06 in vitro. Genotype 1a NAbs afforded no protec...

journal_title：Journal of virology

authors： Bukh J,Engle RE,Faulk K,Wang RY,Farci P,Alter HJ,Purcell RH

更新日期：2015-09-01 00:00:00

abstract：:Smallpox was eradicated more than 10 years ago, but infection with another Orthopoxvirus, monkeypox virus, can result in a clinical picture resembling smallpox. Human infection with monkeypox virus is extremely rare, not easily transmitted, and confined to the rain forest belt of Africa (Z. Jezek and F. Fenner, p. 81-...

journal_title：Journal of virology

authors： Douglass N,Dumbell K

更新日期：1992-12-01 00:00:00

abstract：:The nucleotide sequence of the src gene and flanking regions of the Schmidt-Ruppin strain of Rous sarcoma virus (SR-A) was determined. The src region of SR-A was very homologous to that of recovered avian sarcoma virus (rASV1441), with only 17 differences among 1,578 nucleotides. The size of the predicted protein was ...

journal_title：Journal of virology

authors： Takeya T,Hanafusa H

更新日期：1982-10-01 00:00:00

abstract：:Adeno-associated virus (AAV) is a human parvovirus currently being developed as a vector for gene therapy applications. Because the gene transfer vector commonly retains only the AAV terminal repeats, propagation of recombinant AAV (rAAV) requires that the viral replication (Rep) and capsid (Cap) proteins be supplied ...

journal_title：Journal of virology

authors： Vincent KA,Piraino ST,Wadsworth SC

更新日期：1997-03-01 00:00:00

abstract：:The hepadnavirus reverse transcriptase is a multifunction enzyme. In addition to its role in DNA synthesis, the polymerase is required for RNA packaging and also functions as the primer for minus-strand DNA synthesis. Previously, we demonstrated that the protein-priming activity of the polymerase requires a viral RNA ...

journal_title：Journal of virology

authors： Wang GH,Zoulim F,Leber EH,Kitson J,Seeger C

更新日期：1994-12-01 00:00:00

abstract：:Competitive quantitative PCR and reverse transcriptase-PCR were used to quantitate DNA and RNA from an attenuated ribonucleotide reductase-deleted herpes simplex virus type 1 (HSV-1) mutant in the rat trigeminal ganglion after peripheral inoculation following corneal scarification. Amplification of ganglionic DNA with...

journal_title：Journal of virology

authors： Ramakrishnan R,Levine M,Fink DJ

更新日期：1994-11-01 00:00:00

abstract：:The involvement of mouse mammary tumor virus (MTV) in the development of mammary tumors of nonviral etiology in BALB/c mice was studied by measuring the levels of MTV RNA, MTV DNA, and MTV proteins in spontaneously arising and hormonally, chemically, and/or physically induced mammary tumors of BALB/c females. The foll...

journal_title：Journal of virology

authors： Michalides R,van Deemter L,Nusse R,Hageman P

更新日期：1979-07-01 00:00:00

abstract：:Artificial target sequences for tissue-specific miRNAs have recently been introduced as a new means for altering the tissue tropism of viral replication. This approach can be used to improve the safety of oncolytic viruses for cancer virotherapy by restricting their replication in unwanted tissues, such as the liver. ...

journal_title：Journal of virology

authors： Ylösmäki E,Martikainen M,Hinkkanen A,Saksela K

更新日期：2013-01-01 00:00:00

abstract：:In this paper, we report that the DNA of bovine mammillitis virus (BMV) consists of two covalently linked components that are 71.5 x 10(6) and 15.7 x 10(6) in molecular weight and designated L and S, respectively. We further report that the BMV DNA consists of four equimolar populations differing only in the orientati...

journal_title：Journal of virology

authors： Buchman TG,Roizman B

更新日期：1978-01-01 00:00:00

abstract：:Late (L) domains containing the highly conserved sequence PPXY were first described for retroviruses, and later research confirmed their conservation and importance for efficient budding of several negative-stranded RNA viruses. Rabies virus (RV), a member of the Rhabdoviridae family, contains the sequence PPEY (amino...

journal_title：Journal of virology

authors： Wirblich C,Tan GS,Papaneri A,Godlewski PJ,Orenstein JM,Harty RN,Schnell MJ

更新日期：2008-10-01 00:00:00

abstract：UNLABELLED:Woodchuck hepatitis virus (WHV), a close relative of human hepatitis B virus (HBV), has been a key model for disease progression and clinical studies. Sequences of the assembly domain of WHV and HBV core proteins (wCp149 and hCp149, respectively) have 65% identity, suggesting similar assembly behaviors. We r...

journal_title：Journal of virology

authors： Kukreja AA,Wang JC,Pierson E,Keifer DZ,Selzer L,Tan Z,Dragnea B,Jarrold MF,Zlotnick A

更新日期：2014-12-01 00:00:00

abstract：:Hypervariable region 5 (HVR5) is a hydrophilic, serotypically nonconserved loop of the hexon monomer which extrudes from the adenovirus (Ad) capsid. We have replaced the HVR5 sequence of Ad5 with that of heterologous peptides and studied their effects on virus viability and peptide accessibility. A poliovirus model ep...

journal_title：Journal of virology

authors： Vigne E,Mahfouz I,Dedieu JF,Brie A,Perricaudet M,Yeh P

更新日期：1999-06-01 00:00:00

abstract：:The functions of the two rotavirus glycoproteins were investigated by using tunicamycin and a variant of SA11 rotavirus having nonglycosylated VP7. Results showed that glycosylation of VP7 is not required for normal viral morphogenesis and infectivity and suggested that the nonstructural glycoprotein is involved in as...

journal_title：Journal of virology

authors： Petrie BL,Estes MK,Graham DY

更新日期：1983-04-01 00:00:00

abstract：:Mixed infection of a cell by vesicular stomatitis virus (VSV) and retroviruses results in the production of progeny virions bearing the genome of one virus encapsidated by the envelope proteins of the other. The mechanism for the phenomenon of pseudotype formation is not clear, although specific recognition of a viral...

journal_title：Journal of virology

authors： Emi N,Friedmann T,Yee JK

更新日期：1991-03-01 00:00:00

abstract：:Rabies virus nucleoprotein (N) plays vital roles in regulation of viral RNA transcription and replication by encapsidation of the nascent genomic RNA. Rabies virus N is phosphorylated, and previous studies demonstrated that mutation of the phosphorylated serine at position 389 to alanine resulted in reduction of viral...

journal_title：Journal of virology

authors： Wu X,Gong X,Foley HD,Schnell MJ,Fu ZF

更新日期：2002-05-01 00:00:00

abstract：:An important site for bovine herpesvirus 1 (BoHV-1) latency is sensory neurons within trigeminal ganglia (TG). The synthetic corticosteroid dexamethasone consistently induces BoHV-1 reactivation from latency. Expression of four Krüppel-like transcription factors (KLF), i.e., KLF4, KLF6, PLZF (promyelocytic leukemia zi...

journal_title：Journal of virology

authors： El-Mayet FS,Sawant L,Thunuguntla P,Zhao J,Jones C

更新日期：2020-01-31 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract disease in infants and the elderly, but no safe and effective RSV vaccine is yet available. For reasons that are not well understood, RSV is only weakly immunogenic, and reinfection occurs throughout life. This has complicated the sea...

journal_title：Journal of virology

authors： Martinez-Sobrido L,Gitiban N,Fernandez-Sesma A,Cros J,Mertz SE,Jewell NA,Hammond S,Flano E,Durbin RK,García-Sastre A,Durbin JE

更新日期：2006-02-01 00:00:00