Abstract:
OBJECTIVE:To compare c-kit-positive interstitial Cajal-like cells (ICC) and Caveolin-1 protein levels as a pacemaker and signaling molecules, on ureteropelvic junction (UPJ) specimens, between two groups of pediatric patients with and without ureteropelvic junction obstruction (UPJO). METHODS:We evaluated the UPJ specimens of 45 pediatric patients operated between 2005- 2012 retrospectively. Group 1 included 37 patients who underwent dismembered pyeloplasty due to UPJO. Eight patients underwent nephrectomy by the other reasons (renal tumor, trauma etc) and had normal UPJ were accepted as Group 2. The specimens were examined immunohistochemically with CD117 and Caveolin-1 antibody. According to the total number of ICC; 0-5 cells were accepted as a few (1), 610 cells as moderate (2), and > 10 as many (3). According to the staining intensity of Caveolin-1 at muscle tissue, a subjective evaluation was performed as; mild staining (1), moderate staining (2) and strong staining (3). RESULTS:The mean value of ICC distribution was calculated 1.37 ± 0.54 in Group 1 and 2.13 ± 0.64 in Group 2 (p = 0.003), and the median value of ICC distribution was found 1 [1-3] in Group 1 and 2 [1-3] in Group 2 (p = 0.008). Median values for the intensity of staining with Caveolin-1 were found 2 [1-3] in the Group 1, and 2.5 [2-3] in the Group 2 (p = 0.025). CONCLUSIONS:A decrease in ICC and Caveolin-1 levels support that there may be a relationship between ICC and Caveolin-1 for UPJO associated with signal transduction and peristalsis in urinary system. OBJETIVO:Comparar las células intersticiales Cajal-like, c-kit positivas, y los niveles de proteína Caveolina -1 como marcapasos y moléculas señalizadoras en piezas de unión pieloureteral (UPU) comparando dos grupos de pacientes pediátricos con o sin obstrucción de la UPU.MÉTODOS: Evaluamos retrospectivamente las piezas obtenidas en la operación de 45 pacientes pediátricos entre 2005-2012. El grupo 1 incluía 37 pacientes sometidos a pieloplastia desmembrada por estenosis de UPU. Ocho pacientes que fueron sometidos a nefrectomía por otras razones (tumor renal, traumatismo, etc) y tenían una UPU normal se incluyeron en el grupo 2. Las piezas fueron examinadas mediante inmunohistoquímica con CD117 y Caveolina-1 en el tejido muscular. Se realizó una evaluación subjetiva como: tinción leve (1), tinción moderada (2) y tinción fuerte (3). RESULTADOS:Se calculó el valor medio de la distribución de las células intersticiales de Cajal (CIC), 1,37 ± 0,54 en el Grupo 1 y 2,13 ± 0,64 en el Grupo 2 (p = 0,003), y la mediana, de 1 [1-3] en el Grupo 1 y 2 [1-3] en el Grupo 2 (p = 0,008). Los valores de la mediana para la intensidad de la tinción con Caveolina- 1 fueron de 2 [1-3] en el Grupo 1 y 2,5 [2-3] en el Grupo 2 (p = 0,025). CONCLUSIONES:Una disminución de las células intersticiales de Cajal y los niveles de Caveolina 1 apoyan que puede haber una relación entre las células intersticiales de Cajal y la Caveolina 1 en la estenosis de la UPU asociada con la transducción de la señal y el peristaltismo en el sistema urinario.
journal_name
Arch Esp Uroljournal_title
Archivos espanoles de urologiaauthors
Bayrak O,Basmaci I,Bozdag Z,Sen H,Erturhan S,Balat A,Seckiner Isubject
Has Abstractpub_date
2019-09-01 00:00:00pages
690-696issue
7eissn
0004-0614issn
1576-8260pii
2019-72-7-4dc1e6ad797e3bfd11cc8a55db3fbc18c2a375f9journal_volume
72pub_type
杂志文章abstract::There is currently no existing methodology for evaluating normal exocrine function in the healthy rat. Consequently, most of the experimental studies that have been conducted are incomplete. For this reason, we developed an experimental model to investigate the testicular exocrine function using spermatozoa obtained f...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract:OBJECTIVES:To investigate the postoperative surgical complications and patient satisfaction with the outside-in transobturator tape (TOT) procedure performed by an experienced surgeon compared to those performed by residents in training. METHODS:Patients who received TOT surgery performed by a resident under supervisi...
journal_title:Archivos espanoles de urologia
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abstract:OBJECTIVE:An uncommon complication of prostatic transrectal biopsy is described. METHODS/RESULTS:A case of peritonitis arising from a recto-peritoneal fistula after transrectal biopsy of the prostate is reported. The patient presented symptoms of peritonitis 15 days after undergoing ambulatory transrectal prostatic bi...
journal_title:Archivos espanoles de urologia
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abstract::Six patients diagnosed as having urothelial carcinoma with varying degrees of squamous features are described. Four had pure squamous carcinoma. Two had transitional cell carcinoma (1 with squamous areas and the other had carcinoma in situ). The histological analyses of specimens were performed using immunohistochemic...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
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更新日期:1990-11-01 00:00:00
abstract:OBJECTIVES:The objective of this work is to evaluate the current role of conventional transrectal ultrasound guided biopsy of the prostate in the diagnosis of cancer. With this aim we review its indications, the various techniques, associated complications and limitations of this test. METHODS:We performed a bibliogra...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章,评审
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abstract::Despite representing a small percentage of the transplant activity in our country, living donor kidney transplantation is a good alternative for the future because the needs exceed the offer of cadaver donor organs. We present the evolution of living donor kidney transplantation in Spain from the beginning in accordan...
journal_title:Archivos espanoles de urologia
pub_type: 历史文章,杂志文章
doi:10.4321/s0004-06142005000600005
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abstract::Rectal involvement secondary to adenocarcinoma of the prostate is uncommon and carries a poor prognosis. Distinguishing secondary from primary rectal tumors is mandatory, since each condition warrants a completely different treatment. There are at least five forms of clinicopathological involvement, depending on the r...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
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更新日期:1993-03-01 00:00:00
abstract:OBJECTIVE:To assess Latzko's colpocleisis with bilateral Martius flap as a solution for vesico vaginal fistula secondary to radiotherapy. METHOD:65 year old woman with past medical history of cervix adenocarcinoma treated with hysterectomy, pelvic radiotherapy and brachytherapy. She also had terminal colostomy for re...
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doi:
更新日期:2011-11-01 00:00:00
abstract::A case of polyorchism is described and the literature reviewed, highlighting the rarity of this pathological condition. To our knowledge, only 70 cases have been reported in the world literature. Similarly, Nocks' embryological development theory is discussed herein. The present case was diagnosed intraoperatively. No...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章,评审
doi:
更新日期:1991-04-01 00:00:00
abstract::We made a crystallographic analysis of 87 mixed-nucleus stones and found 4 groups of stones of this kind, which are as follow: urico-oxalic, oxalico-uric, phosphato-oxalic and oxalic-phosphatic. We did not find any mixed-nucleus, urico-phosphatic or phosphatico-uric stones and we explain this fact according to the kno...
journal_title:Archivos espanoles de urologia
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doi:
更新日期:1980-11-01 00:00:00
abstract:OBJECTIVE:To discuss briefly the new therapeutic strategies for poor-prognosis testicular germ cell cancer. METHODS:The use of new drugs in first line chemotherapy, intensive alternating and sequential chemotherapy and high dose chemotherapy with autologous bone marrow or stem cell transplantation are briefly discusse...
journal_title:Archivos espanoles de urologia
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doi:
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abstract:OBJECTIVES:To determine and compare the antioxidant power, cellular damage by lipidic peroxidation, and membrane damage in normal patients and patients with prostate cancer, so determining the antitumoral capacity. METHODS:The study population included 19 patients with elevated total PSA, greater than 4 ng/ml, with a ...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:10.4321/s0004-06142008000500001
更新日期:2008-06-01 00:00:00
abstract::Tumors of mesothelial origin account for 1-5% of all vesical neoplasms. Leiomyomas, although rare, are the most frequently encountered. Three patients diagnosed as having leiomyoma are presented. Two had leiomyoma of the bladder and one had leiomyoma of the distal urethra. The etiopathogenesis, diagnosis and treatment...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract:OBJECTIVE:To describe the clinical conditions, the radiological findings and the management of a case of seminal vesicle abscess. METHODS:A 47-year old man presented with irritative voiding symptoms, fever, diminished ejaculated volume, hematuria and testicular pain. Diagnosis was made with digital rectal examination,...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract::Vesicoureteral reflux remains one of the most controversial subjects in paediatric urology. The flooding of publications on reflux makes the understanding of this anomaly and its treatments quite opaque. Evidence Based Medicine might be a helpful tool to clarify the various approaches of reflux reflected in 6.715 publ...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章,评审
doi:10.4321/s0004-06142008000200008
更新日期:2008-03-01 00:00:00
abstract::Most of the urodynamic studies are conducted in the laboratory during a brief recording time and under nonphysiological conditions and, thus, may fail to unfold the nature of existing pathological conditions of the lower urinary tract; false positives and false negatives are possible. To overcome some of the difficult...
journal_title:Archivos espanoles de urologia
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract:OBJECTIVES:We evaluated the form of presentation, clinical features and analytical values and their relationship with survival in renal cell carcinoma patients and analyzed the efficiency of different diagnostic and staging procedures. METHODS:We reviewed the form of presentation, clinical features, staging procedures...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:To report two cases of verrucous carcinoma of the penis, a rare tumor with a characteristic course and specific treatment that accounts for approximately 1% of tumors in the male. METHODS:Two patients, aged 86 and 51 years, with verrucous carcinoma of the penis are described. Treatment was by partial penecto...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:The management of stone disease in renal abnormalities is a challenge for urologist due to its rarity. The aim of the current manuscript is to report our experience in Retrograde Intrarenal Surgery (RIRS) in 4 complex-abdnormal cases using the flexible videoureterorrenoscopy. MATERIAL AND METHODS:Data was pr...
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更新日期:2020-04-01 00:00:00
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journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract::The authors present four cases of metastasic penis tumours, two of which followed a prostate carcinoma, one vesical carcinoma and the other a carcinoma of the excretory duct. They make a review of world literature on the subject and study the possible ways of dissemination as well as the clinical picture and different...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:1980-03-01 00:00:00
abstract:OBJECTIVE:Renal cell carcinoma is constantly associated with calcification, but ossification is extremely scarce. METHOD: We retrospectively analyzed two cases with clear cell renal cell carcinoma with osseous metaplasia. RESULTS: We criticized the oldest case of woman whose a 32x31mm irregular renal mass with calcific...
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doi:
更新日期:2001-09-01 00:00:00
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journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:2012-09-01 00:00:00
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doi:
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVES:To determine the frecuency of complications during the management of bladder trauma and its associated factors in a third level reference Hospital. METHODS:A cross-sectional study of adult patients admitted in a reference Hospital from January 2006 to June 2011 with the diagnosis of bladder trauma. We ident...
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doi:
更新日期:2014-05-01 00:00:00
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journal_title:Archivos espanoles de urologia
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVES:The value of ultrasonography for the study of female urinary incontinence has been redefined over the last years. METHODS:We review the literature about the value of ultrasound in the workup of females with urinary incontinence, mainly transperineal ultrasound for the female stress urinary incontinence (SUI...
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journal_title:Archivos espanoles de urologia
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doi:
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