Abstract:
Objective:5-Hydroxymethylfurfural (HMF) is formed when sugars are heated in the presence of amino acids. HMF is naturally present in many foods. To investigate the toxic effects of HMF on the reproductive system of peripubertal rats. Methods:In the study, 24 immature female Wistar rat were divided into three groups: control (CT) fed with no HMF; low dose fed with 750 mg/kg/day of HMF and high dose (HD) groups fed with 1500 mg/kg/day of HMF. All groups received these diets for three weeks from postnatal day (PND) 21. The vaginal opening (VO) was monitored daily and euthanasia occurred on PND 44. Gonadotropin, estradiol (E2), progesterone and anti-Müllerian hormone (AMH) concentrations were measured. Reproductive organ weights and ovarian follicle counts were compared. Results:The HD HMF group had earlier VO. Higher mean luteinising hormone (2.9±1.2 vs 1.3±0.3 mIU/mL) and mean E2 (34.7±8.8 vs 21.2±3.9 pg/mL) and lower mean AMH (2.7±0.5 vs 4.7±0.7 ng/mL) concentrations were found in the HD compared to the CT group. The HD group also had increased number of secondary atrophic follicles. Conclusion:These results indicate that peripubertal exposure to HMF at HD result in precocious puberty and decreased AMH levels in female Wistar rats.
journal_name
J Clin Res Pediatr Endocrinoljournal_title
Journal of clinical research in pediatric endocrinologyauthors
Elmaoğulları S,Kadan E,Anadol E,Gökçeoğlu A,Çetinkaya S,Yarım GF,Uçaktürk SA,Aycan Zdoi
10.4274/jcrpe.galenos.2019.2019.0080subject
Has Abstractpub_date
2020-03-19 00:00:00pages
79-85issue
1eissn
1308-5727issn
1308-5735journal_volume
12pub_type
杂志文章abstract:Objective:No large study has been conducted to date to compare the effectiveness of prednisolone, alendronate and pamidronate as first-line treatment in children with hypercalcemia due to vitamin D intoxication. The aim was to perform a multicenter, retrospective study assessing clinical characteristics and treatment r...
journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章,多中心研究
doi:10.4274/jcrpe.galenos.2018.2018.0131
更新日期:2019-05-28 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
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journal_title:Journal of clinical research in pediatric endocrinology
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doi:10.4274/jcrpe.galenos.2020.2020.0009
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
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journal_title:Journal of clinical research in pediatric endocrinology
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journal_title:Journal of clinical research in pediatric endocrinology
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journal_title:Journal of clinical research in pediatric endocrinology
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pub_type: 杂志文章
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journal_title:Journal of clinical research in pediatric endocrinology
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