Abstract:
:The effects of a single dose of surfactant TA were assessed in premature neonates (birth weight 750 to 1749 g) with respiratory distress syndrome (RDS) in a multicenter, double-blind, randomized clinical trial. Only neonates with surfactant deficiency and without ultrasonographic evidence of intracranial hemorrhage greater than or equal to grade II were enrolled. Fifty-four patients received surfactant (100 mg of phospholipid per kilogram of body weight) and 46 patients received an air placebo within 8 hours of life. Treatment with this surfactant resulted in a significant reduction in the severity of RDS with a concomitant increase in the proportion of neonates with mild disease. The frequency of pulmonary interstitial emphysema and of pneumothorax was significantly lower in treated neonates compared with control neonates (2% vs 26%, P = .0008, and 7% vs 39%, P = .0004, respectively). The frequency of intracranial hemorrhage was significantly lower in the surfactant group compared with the control group (20% vs 54%, P = .0008) and was also reduced for the smallest neonates in the surfactant group (13% vs 73%, P = .00008). When categorized according to severity of intracranial hemorrhage and severity of bronchopulmonary dysplasia, the surfactant group was at a significant advantage (adjusted Cochran-Mantel-Haenszel X2 = 10.72, P less than .001 and X2 = 4.43, P = .036, respectively). The proportion of neonates surviving without intracranial hemorrhage and/or bronchopulmonary dysplasia was 63% in the surfactant group vs 26% in the control group (P = .0004); as for the smallest neonates, it was 58% in the surfactant group vs 4% in the control group (P = .0002). There were no differences between the groups with respect to the frequency of patent ductus arteriosus (46% vs 37%), pulmonary hemorrhage (6% vs 7%), necrotizing enterocolitis (0% vs 2%), sepsis (4% vs 2%), retinopathy of prematurity (13% vs 22%), or death (15% vs 22%). It is concluded that treatment with the single-dose surfactant regimen used in this study reduces the severity of respiratory distress during the 48 hours after treatment and decreases the major pulmonary morbidity and intracranial hemorrhage in premature neonates with RDS. Further studies are needed to determine whether (1) treatment at birth or as soon as after RDS is diagnosed and (2) the use of multiple dose of this surfactant would result in any additional benefits.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Fujiwara T,Konishi M,Chida S,Okuyama K,Ogawa Y,Takeuchi Y,Nishida H,Kito H,Fujimura M,Nakamura Hsubject
Has Abstract,Author List Incompletepub_date
1990-11-01 00:00:00pages
753-64issue
5eissn
0031-4005issn
1098-4275journal_volume
86pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
PEDIATRICS文献大全abstract::A newborn with graft-vs-host (GVH) disease following an exchange transfusion was treated by attempting to eradicate the incompatible graft and to reconstitute the child hematologically and immunologically with a bone marrow transplant. The patient was a female term infant (blood group B, Rh+ Coombs test positive) who ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1982-07-01 00:00:00
abstract:OBJECTIVES:The objectives of this study were to characterize noise and light levels for extremely low birth weight newborns throughout their stay in the NICU, evaluate factors influencing noise and light levels, and determine whether exposures meet recommendations from the American Academy of Pediatrics. METHODS:Sound...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-3418
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:X-linked hypophosphatemia (XLH) is characterized clinically by rickets and growth retardation. Conventional treatment of XLH with oral phosphate and vitamin D fails to normalize linear growth. Objective. To determine the benefit and the potential side effects of recombinant human growth hormone (rhGH) therap...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1542/peds.100.5.879
更新日期:1997-11-01 00:00:00
abstract::In this cross-sectional study, the vision-screening process is described for 8417 children aged 3 to 5 seen for health supervision in a group of 102 pediatric practices in 23 states and Puerto Rico. Three hundred forty children who failed screening (63% of those who failed) were followed up 2 months after initial scre...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to determine parent and provider knowledge and awareness of newborn screening; to gather opinions from parents, providers, and newborn screening professionals about the content and timing of newborn screening education; and to use consensus data to formulate recommendations and to...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-2633M
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:Health-e-Access, a telemedicine service providing care for acute illnesses in children, has delivered >6500 telemedicine visits from 10 primary care practices in Rochester, New York, by using telemedicine access at 22 child care and school sites. The goal was to assess the hypotheses that children served by H...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-2698
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:To investigate whether single-nucleotide polymorphisms in the promoter regions of endotoxin-responsive genes CD14 and tumor necrosis factor-alpha (TNF-alpha) are associated with biliary atresia (BA) and idiopathic neonatal cholestasis (INC). METHODS:We obtained genomic DNA from 90 patients with established d...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-1900
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVE:Most studies of parent-adolescent communication about sexuality focus on the frequency of communication without distinguishing between the breadth of topics covered and repetition. The goal of this study was to assess the independent influence of breadth and repetition of sexual discussion on adolescents' per...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2007-2156
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:Our goal was to describe the neurologic and clinical features of affected males from families with X-linked patterns of severe mental retardation, hypotonia, recurrent respiratory infection, and microduplication of Xq28 that consistently includes the MECP2 (methyl-CpG binding protein 2) gene. STUDY DESIGN:To...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-0395
更新日期:2006-12-01 00:00:00
abstract::Tobacco use is the leading preventable cause of morbidity and death in the United States. Because 80% to 90% of adult smokers began during adolescence, and two thirds became regular, daily smokers before they reached 19 years of age, tobacco use may be viewed as a pediatric disease. Every year in the United States, ap...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-2121
更新日期:2009-11-01 00:00:00
abstract::Metoclopramide treatment has been shown to augment milk production by stimulating prolactin secretion in women in whom lactational insufficiency develops after a full-term pregnancy. The effect of metoclopramide therapy in 23 women who were delivered of premature infants (birth weight 1,314 +/- 115 g, gestational age ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
abstract::Immunochemical studies of the enzyme defect in the first reported child with acute hepatic porphyria due to homozygous delta-aminolevulinic acid dehydratase deficiency are described. This enzyme activity was markedly decreased (approximately 2% of the normal control level) in the proband, a 3-year-old boy, and interme...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1987-12-01 00:00:00
abstract::The location of invasive infections is difficult to detect in infants, in part due to their inability to localize signs and symptoms. However, identifying the location often significantly alters clinical management by extending the duration of antibiotic therapy or revealing a source requiring surgical intervention. C...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-0732
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To identify the epidemiological characteristics and transmission patterns of pediatric patients with the 2019 novel coronavirus disease (COVID-19) in China. METHODS:Nationwide case series of 2135 pediatric patients with COVID-19 reported to the Chinese Center for Disease Control and Prevention from January 1...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2020-0702
更新日期:2020-06-01 00:00:00
abstract::Twenty-nine near miss for sudden infant death syndrome and thirty normal infants between the ages of 3 weeks and 6 months were monitored polygraphically for 24 hours. The distribution of sleep and abnormal respiratory events were analyzed for both groups. On the basis of mixed and obstructive apnea, 12-hour nocturnal ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1981-09-01 00:00:00
abstract::Adverse reactions and antibody response to pertussis toxin, ie, antitoxin, after a booster injection of an acellular pertussis vaccine were studied in 2-year-old children. A majority (212/241) of the children had previously been immunized with either two or three doses of the acellular vaccine at the ages of 6, 7, and...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVE:Our objective was to determine whether parent-reported, high-quality primary care was associated with decreased nonurgent pediatric emergency department utilization. METHODS:A retrospective analysis of prospectively collected data for a cohort of children from the 2000-2001 and 2001-2002 Medical Expenditure ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-3518
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Inhaled nitric oxide (iNO) is an effective therapy for pulmonary hypertension and hypoxic respiratory failure in term infants. Fourteen randomized controlled trials (n = 3430 infants) have been conducted on preterm infants at risk for chronic lung disease (CLD). The study results seem contradictory. DESIGN/...
journal_title:Pediatrics
pub_type: 杂志文章,meta分析
doi:10.1542/peds.2010-2725
更新日期:2011-10-01 00:00:00
abstract::A 3-week-old infant awoke with a fever. He was taken to the doctor who noted that the child was irritable. The doctor took him to the hospital where a resident performed a spinal tap, started an intravenous (IV) line, and ordered antibiotics. The entire drama, from entering the doctor's office to infusion of ampicilli...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.101.4.e6
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:In 2013-2014, an outbreak of serogroup B meningococcal disease occurred among persons linked to a New Jersey university (University A). In the absence of a licensed serogroup B meningococcal (MenB) vaccine in the United States, the Food and Drug Administration authorized use of an investigational MenB vaccin...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2014-4015
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Parental smoking has been associated with increased rates of sudden infant death syndrome, low birth weight, otitis media, asthma, and decreased lung growth. No prior parent surveys have assessed national rates of screening and counseling for parental tobacco use in the context of their child's visit to prim...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.112.5.1146
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:Outpatient asthma management remains suboptimal. We previously reported significant improvements in asthma guideline adherence and outcomes in children by using quality-improvement processes and community health workers. We hypothesized that a larger project could achieve comparable outcome improvements with ...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2010-1962
更新日期:2011-07-01 00:00:00
abstract::The safe sedation of children for procedures requires a systematic approach that includes the following: no administration of sedating medication without the safety net of medical supervision; careful presedation evaluation for underlying medical or surgical conditions that would place the child at increased risk from...
journal_title:Pediatrics
pub_type: 杂志文章,实务指引
doi:10.1542/peds.2006-2780
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:Circumcision is a common neonatal surgical procedure routinely performed without the use of anesthesia. The purpose of this study was to evaluate the safety and efficacy of topical lidocaine cream as an anesthetic for circumcision. METHODS:Thirty newborns were studied in a randomized, double-blind, placebo-c...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVE:A prospective hospital-based cohort study was conducted to determine the prevalence rates of cryptorchidism at birth, 3 months, and 1 year of age. DESIGN:A total of 6935 consecutive male neonates delivered at Mount Sinai Hospital in New York City between October 1987 and October 1990 were examined at birth f...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVES:To update clinical practice guidelines to assist primary care (PC) clinicians in the management of adolescent depression. This part of the updated guidelines is used to address practice preparation, identification, assessment, and initial management of adolescent depression in PC settings. METHODS:By using ...
journal_title:Pediatrics
pub_type: 杂志文章,实务指引
doi:10.1542/peds.2017-4081
更新日期:2018-03-01 00:00:00
abstract::Chronic intestinal pseudo-obstruction is a rare disorder that affects the motility of the gastrointestinal tract. It results in acute or subacute intestinal obstruction symptoms in the absence of mechanical lesion. It can lead to intestinal failure in children with significant strain on nutrition, growth, and developm...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-0007
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:As neonatal discharge before 24 hours of life becomes commonplace, the rejection of congenital hypothyroidism (CH) screening specimens obtained too early has created the need for numerous additional tests. We sought to determine whether the specimens obtained before 24 hours could be used safely. METHODS:Dur...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Diagnostic imaging is often used in the evaluation of children with possible appendicitis. The utility of imaging may vary according to a patient's age and gender. The objectives of this study were (1) to examine the use of computed tomography (CT) and ultrasound for age and gender subgroups o...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-3375
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:To provide reference data for ambulatory blood pressure monitoring (ABPM) and to determine the influence of age, sex, and race on these values. METHODS:ABPM was performed on 300 healthy, normotensive boys and girls between the ages of 10 and 18 years, including 160 boys and 140 girls, of whom 149 were white ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00