Deletion of scavenger receptor A protects mice from progressive nephropathy independent of lipid control during diet-induced hyperlipidemia.

Abstract:

:Scavenger receptor A (SR-A) is a key transmembrane receptor in the endocytosis of lipids and contributes to the pathogenesis of atherosclerosis. To assess its role in hyperlipidemic chronic kidney disease, wild-type and SR-A-deficient (knockout) mice underwent uninephrectomy followed by either normal or high-fat diet. After 16 weeks of diet intervention, hyperlipidemic wild-type mice presented characteristic features of progressive nephropathy: albuminuria, renal fibrosis, and overexpression of transforming growth factor (TGF)-β1/Smad. These changes were markedly diminished in hyperlipidemic knockout mice and attributed to reduced renal lipid retention, oxidative stress, and CD11c(+) cell infiltration. In vitro, overexpression of SR-A augmented monocyte chemoattractant protein-1 release and TGF-β1/Smad activation in HK-2 cells exposed to oxidized low-density lipoprotein. SR-A knockdown prevented lipid-induced cell injury. Moreover, wild-type to knockout bone marrow transplantation resulted in renal fibrosis in uninephrectomized mice following 16 weeks of the high-fat diet. In contrast, knockout to wild-type bone marrow transplantation led to markedly reduced albuminuria, CD11c(+) cell infiltration, and renal fibrosis compared to wild-type to SR-A knockout or wild-type to wild-type bone marrow transplanted mice, without difference in plasma lipid levels. Thus, SR-A on circulating leukocytes rather than resident renal cells predominantly mediates lipid-induced kidney injury.

journal_name

Kidney Int

journal_title

Kidney international

authors

Wang W,He B,Shi W,Liang X,Ma J,Shan Z,Hu Z,Danesh FR

doi

10.1038/ki.2011.457

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

1002-1014

issue

10

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)55195-8

journal_volume

81

pub_type

杂志文章
  • Influence of hematocrit on the measurement of lipoproteins demonstrated by the example of lipoprotein(a).

    abstract:BACKGROUND:The measurement of many parameters of human blood is usually performed in plasma or serum. Since lipoproteins or apolipoproteins, for example, are found almost exclusively in the plasma fraction after low-speed centrifugation, these parameters can be expected to be distributed in a different plasma volume de...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.1998.00086.x

    authors: Kronenberg F,Trenkwalder E,Kronenberg MF,König P,Utermann G,Dieplinger H

    更新日期:1998-10-01 00:00:00

  • IL-1beta, TNF-alpha, TGF-beta, and bFGF expression in bone biopsies before and after parathyroidectomy.

    abstract:BACKGROUND:There is growing evidence pointing to an involvement of cytokines and growth factors in renal osteodystrophy. In this study, the expression of interleukin-l beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), and basic fibroblast growth factor (bFGF) in bone...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.2003.00835.x

    authors: Santos FR,Moysés RM,Montenegro FL,Jorgetti V,Noronha IL

    更新日期:2003-03-01 00:00:00

  • Gut microbiome and kidney stone disease: not just an Oxalobacter story.

    abstract::Intestinal regulation of oxalate absorption is a complex mechanism, not exclusively reliant on the oxalate-degrading anaerobe Oxalobacter formigenes. Using metagenomics, Miller et al. were able to describe a network of bacterial taxa co-occurring with Oxalobacter formigenes in fecal samples from non-stone forming cont...

    journal_title:Kidney international

    pub_type: 评论,杂志文章

    doi:10.1016/j.kint.2019.03.020

    authors: Ticinesi A,Nouvenne A,Meschi T

    更新日期:2019-07-01 00:00:00

  • Detection of glomerular complement C3 fragments by magnetic resonance imaging in murine lupus nephritis.

    abstract::One of the challenges of treating patients with glomerulonephritis is to accurately assess disease activity. As renal biopsies are routinely stained for deposits of C3 activation fragments and glomerular C3 deposits are found in most forms of glomerulonephritis, we sought to determine whether a relatively noninvasive ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2011.332

    authors: Sargsyan SA,Serkova NJ,Renner B,Hasebroock KM,Larsen B,Stoldt C,McFann K,Pickering MC,Thurman JM

    更新日期:2012-01-01 00:00:00

  • The Euro-Balance Trial: the effect of a new biocompatible peritoneal dialysis fluid (balance) on the peritoneal membrane.

    abstract:BACKGROUND:Although peritoneal dialysis (PD) is a widely accepted form of renal replacement therapy (RRT), concerns remain regarding the bioincompatible nature of standard PD fluid. In order to evaluate whether a newly formulated fluid of neutral pH, and containing low levels of glucose degradation products (GDP), resu...

    journal_title:Kidney international

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1523-1755.2004.00747.x

    authors: Williams JD,Topley N,Craig KJ,Mackenzie RK,Pischetsrieder M,Lage C,Passlick-Deetjen J,Euro Balance Trial Group.

    更新日期:2004-07-01 00:00:00

  • Anionization of an antigen promotes glomerular binding and immune complex formation.

    abstract::Bovine serum albumin (BSA, pI 4.9) was maleylated to yield highly anionic MBSA (pI 3.0). Maleylation of BSA lead to an expansion of molecular size of native BSA from an effective molecular radius (EMR) of 37 A to 57 A for MBSA as assessed by gel filtration chromatography. MBSA, but not BSA, bound to the peripheral cap...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1988.161

    authors: Barnes JL,Reznicek MJ,Radnik RA,Venkatachalam MA

    更新日期:1988-08-01 00:00:00

  • Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury.

    abstract::Mutations in the complement regulatory proteins are associated with several different diseases. Although these mutations cause dysregulated alternative pathway activation throughout the body, the kidneys are the most common site of injury. The susceptibility of the kidney to alternative pathway-mediated injury may be ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2016.02.036

    authors: Laskowski J,Renner B,Le Quintrec M,Panzer S,Hannan JP,Ljubanovic D,Ruseva MM,Borza DB,Antonioli AH,Pickering MC,Holers VM,Thurman JM

    更新日期:2016-07-01 00:00:00

  • Parathyroid hormone and bone histology: response to hypocalcemia in osteitis fibrosa.

    abstract::The parathyroid hormone (PTH) response to hypocalcemia was studied in 18 hemodialysis patients with osteitis fibrosa, and the relationship with PTH and bone histology in 26 hemodialysis patients. Hypocalcemia was produced during hemodialysis by the use of a dialysate devoid of calcium. Both amino (N) (P less than 0.05...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1984.37

    authors: Voigts A,Felsenfeld AJ,Andress D,Llach F

    更新日期:1984-02-01 00:00:00

  • Oxalate ions and calcium oxalate crystals stimulate MCP-1 expression by renal epithelial cells.

    abstract:BACKGROUND:Crystals of calcium oxalate monohydrate (COM) and excess oxalate ions (OX) stimulate an array of responses inducing localized injury and inflammation in the kidneys. These inflammatory responses are key regulators of development of nephrolithiasis. We propose that monocyte chemoattractant protein-1 (MCP-1), ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.2002.00106.x

    authors: Umekawa T,Chegini N,Khan SR

    更新日期:2002-01-01 00:00:00

  • Enhanced posttransplant management of patients with diabetes improves patient outcomes.

    abstract::The survival of patients with diabetes mellitus in the general population has improved in recent years. Here we assessed whether similar trends have occurred in 1688 kidney recipients, including 413 with diabetes prior to transplant between 1996 and 2007. Compared to patients without diabetes, the 5-year mortality was...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2014.70

    authors: Keddis MT,El Ters M,Rodrigo E,Dean P,Wohlfahrtova M,Kudva YC,Lorenz EC,Cosio FG

    更新日期:2014-09-01 00:00:00

  • L-Arginine transport is augmented through up-regulation of tubular CAT-2 mRNA in ischemic acute renal failure in rats.

    abstract:BACKGROUND:Ischemic acute renal failure (iARF) is associated with increased nitric oxide (NO) production during the reperfusion period, as endothelial nitric oxide synthase (eNOS) is maximally activated, and renal tubular inducible NOS (iNOS) is stimulated. Increased NO production leads to augmented tubular injury, pro...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.2002.t01-1-00622.x

    authors: Schwartz IF,Schwartz D,Traskonov M,Chernichovsky T,Wollman Y,Gnessin E,Topilsky I,Levo Y,Iaina A

    更新日期:2002-11-01 00:00:00

  • Regression of glomerular injury by losartan in experimental diabetic nephropathy.

    abstract::Many features of chronic kidney disease may be reversed, but it is unclear whether advanced lesions, such as adhesions of sclerotic glomerular tufts to Bowman's capsule (synechiae), can resolve during treatment. We previously showed, using a renal ablation model, that the renoprotective effect of the AT-1 receptor blo...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2008.528

    authors: Teles F,Machado FG,Ventura BH,Malheiros DM,Fujihara CK,Silva LF,Zatz R

    更新日期:2009-01-01 00:00:00

  • Smooth muscle tumors associated with X-linked Alport syndrome: carrier detection in females.

    abstract::X-linked Alport syndrome (AS) associated with diffuse esophageal leiomyomatosis (DL) has been reported to be due to deletions removing the 5' ends of both the COL4A5 and COL4A6 genes, encoding the alpha 5 and alpha 6 chains of type IV collagen, respectively, whereas a variety of mutations in COL4A5 has been identified...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1995.489

    authors: Dahan K,Heidet L,Zhou J,Mettler G,Leppig KA,Proesmans W,David A,Roussel B,Mongeau JG,Gould JM

    更新日期:1995-12-01 00:00:00

  • Overexpressed SIRT6 attenuates cisplatin-induced acute kidney injury by inhibiting ERK1/2 signaling.

    abstract::Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase associated with numerous aspects of health and physiology. Overexpression of SIRT6 has emerged as a protector in cardiac tissues against pathologic cardiac hypertrophy. However, the mechanism of this protective effect is not fully understood. Here, both in vivo and in ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2017.10.021

    authors: Li Z,Xu K,Zhang N,Amador G,Wang Y,Zhao S,Li L,Qiu Y,Wang Z

    更新日期:2018-04-01 00:00:00

  • Role of vasopressin in the impaired water excretion of glucocorticoid deficiency.

    abstract::The mechanism whereby glucocorticoid deficiency impairs renal water excretion was studied in the conscious mineralocorticoid-replaced, adrenalectomized rat. Control animals received physiologic replacement with prednisolone, and experimental animals were deprived of glucocorticoid hormone for either 1 or 14 days. The ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1980.110

    authors: Linas SL,Berl T,Robertson GL,Aisenbrey GA,Schrier RW,Anderson RJ

    更新日期:1980-07-01 00:00:00

  • Clinical trial recommendations for potential Alport syndrome therapies.

    abstract::Alport syndrome is experiencing a remarkable increase in preclinical investigations. To proactively address the needs of the Alport syndrome community, as well as offer clarity for future clinical research sponsors, the Alport Syndrome Foundation hosted a workshop to generate consensus recommendations for prospective ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2020.02.029

    authors: Weinstock BA,Feldman DL,Fornoni A,Gross O,Kashtan CE,Lagas S,Lennon R,Miner JH,Rheault MN,Simon JF,Workshop Participants.

    更新日期:2020-06-01 00:00:00

  • Identification of antigenic epitopes in type IV collagen by use of synthetic peptides.

    abstract::Peptides representing potential antigenic regions of the NC-1 and 7-S domains of the human alpha 1 and alpha 2, and bovine alpha 3 chains of type IV collagen were synthesized either chemically or by the recombinant DNA technique and tested by ELISA using antibodies raised in rabbits against the whole type IV collagen ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1993.16

    authors: Kefalides NA,Ohno N,Wilson CB,Fillit H,Zabriski J,Rosenbloom J

    更新日期:1993-01-01 00:00:00

  • Gender-specific association of adiponectin as a predictor of progression of chronic kidney disease: the Mild to Moderate Kidney Disease Study.

    abstract::Progressive renal vascular sclerosis is a key feature of chronic kidney disease (CKD). Adiponectin, an adipokine with potent anti-inflammatory and antiatherosclerotic properties, is associated with insulin resistance, type II diabetes and cardiovascular disease. In this study, we evaluated the predictive value of adip...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/sj.ki.5002191

    authors: Kollerits B,Fliser D,Heid IM,Ritz E,Kronenberg F,MMKD Study Group.

    更新日期:2007-06-01 00:00:00

  • Patients double-seropositive for ANCA and anti-GBM antibodies have varied renal survival, frequency of relapse, and outcomes compared to single-seropositive patients.

    abstract::Co-presentation with both ANCA and anti-GBM antibodies is thought to be relatively rare. Current studies of such 'double-positive' cases report small numbers and variable outcomes. To study this further we retrospectively analyzed clinical features and long-term outcomes of a large cohort of 568 contemporary patients ...

    journal_title:Kidney international

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.kint.2017.03.014

    authors: McAdoo SP,Tanna A,Hrušková Z,Holm L,Weiner M,Arulkumaran N,Kang A,Satrapová V,Levy J,Ohlsson S,Tesar V,Segelmark M,Pusey CD

    更新日期:2017-09-01 00:00:00

  • Influence of pyruvate on ammonia metabolism by renal cortical mitochondria.

    abstract::The effect of the tricarboxylic acid (TCA) cycle precursor, pyruvate, on glutamine metabolism by isolated renal cortical mitochondria was assessed by quantitating its key nitrogen and carbon metabolites. When mitochondria from normal rats were incubated at pH 7.4, pyruvate (2 mM) inhibited ammonia production by almost...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1982.166

    authors: Tannen RL,Kunin AS

    更新日期:1982-09-01 00:00:00

  • Low parathyroid hormone status induced by high dialysate calcium is an independent risk factor for cardiovascular death in hemodialysis patients.

    abstract::Here we studied a possible association between low parathyroid hormone (PTH) status and mortality in incident patients undergoing hemodialysis . A total of 1983 patients were included at baseline and prospectively followed for 24 months. Patients were classified according to their Kidney Disease: Improving Global Outc...

    journal_title:Kidney international

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.kint.2015.12.001

    authors: Merle E,Roth H,London GM,Jean G,Hannedouche T,Bouchet JL,Drüeke T,Fouque D,Daugas E,French Calcium and Phosphate Observatory.

    更新日期:2016-03-01 00:00:00

  • Modulation of Ca2+-activated K+ channel in renal artery endothelium in situ by nitric oxide and reactive oxygen species.

    abstract:BACKGROUND:Endothelium-derived nitric oxide and reactive oxygen species (ROS) have been proposed to regulate vascular tone by complex mechanisms, including the modulation of ion channel function. In endothelial function itself, activation of Ca2+-activated K+ channels (KCa) plays a crucial role by inducing hyperpolariz...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.2003.00051.x

    authors: Brakemeier S,Eichler I,Knorr A,Fassheber T,Köhler R,Hoyer J

    更新日期:2003-07-01 00:00:00

  • Maximal suppression of renin-angiotensin system in nonproliferative glomerulonephritis.

    abstract:BACKGROUND:Elimination of residual proteinuria is the novel target in renoprotection; nevertheless, whether a greater suppression of renin-angiotensin system (RAS) effectively improves the antiproteinuric response in patients with moderate proteinuria remains ill-defined. METHODS:We evaluated the effects of maximizing...

    journal_title:Kidney international

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1523-1755.2003.00015.x

    authors: Iodice C,Balletta MM,Minutolo R,Giannattasio P,Tuccillo S,Bellizzi V,D'Amora M,Rinaldi G,Signoriello G,Conte G,De Nicola L

    更新日期:2003-06-01 00:00:00

  • Relationship of protein intake to urinary oxalate and glycolate excretion.

    abstract::The relationship of protein intake to urinary oxalate and glycolate excretion was examined in a large cohort (N = 101) of normal individuals on self-selected diets and in 11 individuals on controlled protein diets. On self-selected diets no correlation was detected between protein intake and urinary oxalate or glycola...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1993.253

    authors: Holmes RP,Goodman HO,Hart LJ,Assimos DG

    更新日期:1993-08-01 00:00:00

  • Thrombospondin 1 precedes and predicts the development of tubulointerstitial fibrosis in glomerular disease in the rat.

    abstract::Tubulointerstitial fibrosis is one of the most important histologic features that predicts progression in kidney disease. Thrombospondin 1 is an extracellular matrix protein that can activate latent TGF-beta, a cytokine implicated in the pathogenesis of tubulointerstitial fibrosis. We examined the expression of thromb...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.1998.00774.x

    authors: Hugo C,Shankland SJ,Pichler RH,Couser WG,Johnson RJ

    更新日期:1998-02-01 00:00:00

  • Intracellular glutathione influences collagen generation by mesangial cells.

    abstract::The cellular redox state is altered in a number of pathological conditions, including various forms of glomerular injury and diabetes. For example, glucose, via the pentose phosphate pathway generates NADPH, which maintains glutathione (GSH) (part of a major intracellular reducing system) in its reduced state. GSH in ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1994.286

    authors: Shan Z,Tan D,Satriano J,Silbiger S,Schlondorff D

    更新日期:1994-08-01 00:00:00

  • Catecholamines and phosphate excretion by the remnant kidney.

    abstract::The remnant kidney (RK) exhibits an enhanced fractional excretion of phosphate (FEPi) even in the absence of parathyroid hormone (PTH). Thus, factors other than PTH contribute to this adaptive phosphaturia. Dopamine (DA) infusion is phosphaturic, whereas stimulation of adrenoreceptors is antiphosphaturic. Therefore, t...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1993.144

    authors: Isaac J,Berndt TJ,Thothathri V,Tyce GM,Knox FG

    更新日期:1993-05-01 00:00:00

  • Angiotensin II: breathtaking in the renal medulla.

    abstract::Angiotensin II (Ang II) is a major contributor to the progression of renal fibrosis. Wang and colleagues provide evidence that signaling through the prolyl-4-hydroxylase domain (PHD)-hypoxia-inducible factor-1 (HIF-1) pathway mediates profibrotic effects of Ang II in rat renal medullary interstitial cells under normox...

    journal_title:Kidney international

    pub_type: 评论,杂志文章

    doi:10.1038/ki.2010.434

    authors: Haase VH

    更新日期:2011-02-01 00:00:00

  • National trend of the incidence of urolithiasis in Japan from 1965 to 1995.

    abstract:BACKGROUND:A nationwide survey of urolithiasis in Japan was made in order to evaluate the chronological trend of upper urinary tract stones in the Japanese. It succeeded previous studies done in 1955, 1966, 1979, and 1990. METHODS:All outpatient visits to urologists that resulted in a diagnosis of first-episode upper ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.1999.00754.x

    authors: Yoshida O,Terai A,Ohkawa T,Okada Y

    更新日期:1999-11-01 00:00:00

  • Substrate oxidation by isolated single nephron segments of the rat.

    abstract::Substrate oxidation was assessed by measuring 14CO2 production from 14C-labeled substrates in proximal convoluted tubules (PCT), medullary (MTAL), and cortical (CTAL) thick ascending limb of Henle, nephron segments rich in mitochondria and characterized by active solute transport. PCT, MTAL, and CTAL were dissected fr...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1981.100

    authors: Klein KL,Wang MS,Torikai S,Davidson WD,Kurokawa K

    更新日期:1981-07-01 00:00:00