Abstract:
:Variants in the FADS gene cluster modify the activity of polyunsaturated fatty acid (PUFA) desaturation and the lipid composition in human blood and tissue. FADS variants have been associated with plasma lipid concentrations, risk of cardiovascular diseases, overweight, eczema, pregnancy outcomes, and cognitive function. Studies on variations in the FADS genecluster provided some of the first examples for marked gene-diet interactions in modulating complex phenotypes, such as eczema, asthma, and cognition. Genotype distribution differs markedly among ethnicities, apparently reflecting an evolutionary advantage of genotypes enabling active long-chain PUFA synthesis when the introduction of agriculture provided diets rich in linoleic acid but with little arachidonic and eicosapentaenoic acids. Discovering differential effects of PUFA supply that depend on variation of FADS genotypes could open new opportunities for developing precision nutrition strategies based either on an individual's genotype or on genotype distributions in specific populations.
journal_name
Annu Rev Nutrjournal_title
Annual review of nutritionauthors
Koletzko B,Reischl E,Tanjung C,Gonzalez-Casanova I,Ramakrishnan U,Meldrum S,Simmer K,Heinrich J,Demmelmair Hdoi
10.1146/annurev-nutr-082018-124250subject
Has Abstractpub_date
2019-08-21 00:00:00pages
21-44eissn
0199-9885issn
1545-4312journal_volume
39pub_type
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journal_title:Annual review of nutrition
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journal_title:Annual review of nutrition
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pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.25.051804.101917
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journal_title:Annual review of nutrition
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更新日期:2006-01-01 00:00:00
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journal_title:Annual review of nutrition
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.25.050304.092614
更新日期:2005-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.17.1.77
更新日期:1997-01-01 00:00:00
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journal_title:Annual review of nutrition
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更新日期:2016-07-17 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.012809.104813
更新日期:2010-08-21 00:00:00
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journal_title:Annual review of nutrition
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更新日期:2003-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.19.1.141
更新日期:1999-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.21.1.73
更新日期:2001-01-01 00:00:00
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journal_title:Annual review of nutrition
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journal_title:Annual review of nutrition
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journal_title:Annual review of nutrition
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更新日期:2002-01-01 00:00:00
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journal_title:Annual review of nutrition
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更新日期:1986-01-01 00:00:00
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journal_title:Annual review of nutrition
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更新日期:1996-01-01 00:00:00
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更新日期:2007-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
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journal_title:Annual review of nutrition
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更新日期:2000-01-01 00:00:00
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journal_title:Annual review of nutrition
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更新日期:1989-01-01 00:00:00
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journal_title:Annual review of nutrition
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更新日期:2014-01-01 00:00:00